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个人简介

教育经历: 2004.09-2009.07 中山大学 ,细胞生物学,博士毕业,导师:刘林 (长江学者,国家杰青,“973项目首席科学家”) 2007.09-2009.05 University of South Florida ,生殖医学,第一届“国家建设高水平大学公派项目”联合培养博士,导师:David L. Keefe(美国生殖学学会副主席) 2000.09-2004.07 中山大学,生物技术专业 ,本科毕业 1994.09-2000.06江门市第一中学,高中 工作经历: 2017.07-至今中山大学 生命科学学院,副院长 2016.06-至今中山大学 生命科学学院教授,博士生导师 2016.10-2017.07 中山大学 生命科学学院,院长助理 2011.12-2016.06 中山大学 副教授 2011.08-2011.11 中山大学 讲师 2009.08-2011.07中山大学 师资博士后(讲师)

研究领域

1.细胞衰老和再生的调控机制 2.细胞基因编辑技术研究与应用 3.哺乳动物胚胎早期发育机制研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Testis-specific Lypd9 is dispensable for spermatogenesis in mouse. Feng J, Liang P, Chen Y, Zhang X, Songyang Z, Zheng H, Cao S, Huang J*. Molecular Reproduction and Development. 10-Dec-2017 IF:2.3 2. 刘佳慧, 梁普平, 时光, 黄军就.《单碱基基因编辑系统的应用和展望》 世界科技研究与进展2017-11-10 3. Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, Sun Y, Xiong Y, Ma W, Liu Y, Wang Y, Fang J, Liu D, Songyang Z*, Zhou C*, Huang J*. Correction of β-thalassemia mutant by base editor in human embryos. Protein Cell. 2017 Sep 23. IF:5.3 首次在人胚胎中证实单碱基编辑技术有望阻断点突变遗传疾病,Nature、Science、BBC等顶级媒体报道,单碱基基因编辑技术的先驱(David Liu)做正面点评,Nature杂志年度盘点2017年全球科学重要事件中介绍本工作。 4. Chen Y, Liang P, Huang Y, Li M, Zhang X, Ding C, Feng J, Zhang Z, Zhang X, Gao Y, Zhang Q, Cao S, Zheng H, Liu D, Songyang Z*, Huang J*. Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Cell Discovery (2017) 3, 17030; doi:10.1038/celldisc.2017.30 5. Liang P, Zhang X, Chen Y, Huang J*. Developmental history and application of CRISPR in human disease. J Gene Med. 2017 IF:3.6 主编邀请综述 6. Liang P, Sun H, Sun Y, Zhang X, Xie X, Zhang J, Zhang Z, Chen Y, Ding C, Xiong Y, Ma W, Liu D, Huang J*, Songyang Z* Effective gene editing by high-fidelity base editor 2 in mouse zygotes. Protein Cell 2017 IF:5.3 7. Huang D, Lu W, Zou S, Wang H, Jiang Y, Zhang X, Li P, Songyang Z, Wang L, Wang J, Huang J*, Fang L*. Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer. Cancer Sci. 2017 Apr 17. IF:3.9 8. Jiang S, Tang M, Xin H, Huang J*. Assessing Telomerase Activities in Mammalian Cells Using the Quantitative PCR-Based Telomeric Repeat Amplification Protocol (qTRAP). Methods Mol Biol. 2017;1587:95-101. 9. Lin Z, Bao J, Kong Q, Bai Y, Luo F, Songyang Z, Wu Y*, Huang J*. Effective production of recipient male pigs for spermatogonial stem cell transplantation by intratesticular injection with busulfan. Theriogenology. 2017 Feb;89:365-373 IF:1.8 10. Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J*, Wang RF*, Cui J*. TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. Mol Cell. 2016 Oct 6;64(1):105-119. IF:14 11. Zhang X, Liang P, Ding C, Zhang Z, Zhou J, Xie X, Huang R, Sun Y, Sun H, Zhang J, Xu Y, Songyang Z, Huang J*. Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9. Sci Rep. 2016 Sep 2;6:32565. IF:5.2 12. Hu Y, Shi G*, Zhang L, Li F, Jiang Y, Jiang S, Ma W, Zhao Y, Songyang Z, Huang J*. Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX. Sci Rep. 2016 Aug 31;6:32280. IF:5.2 13. 梁普平,黄军就*, 推开人类胚胎基因研究的神秘大门。《生命科学》 2016 年4月,第28卷 第4期。王恩多院士特约综述,周琪院士点评。 14. Huang Y, #, Xiong Y, #, Lin Z, Feng X, Jiang X, Songyang Z, Huang J* Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells. Plos ONE 2015 IF:3.2 15. Li, M., Huang, R., Jiang, X., Chen, Y., Zhang, Z., Zhang, X., Liang, P., Zhan, S., Cao, S., Songyang, Z.*, Huang J* CRISPR/Cas9 Promotes Functional Study of Testis Specific X-linked Gene in vivo. PLOS ONE 2015 IF:3.2 16. Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., Sun, Y., Bai, Y., Songyang, Z., Ma, W., Zhou, C*., Huang, J*. (2015). CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & cell 6, 363-372. IF:3.2 ESI高引论文, Nature、Science、New York Time等媒体热点报道,推动人类基因编辑国际峰会召开!2015年,Nature杂志评选为年度十大科学人物 17. Lu, W., Fang, L., Ouyang, B., Zhang, X., Zhan, S., Feng, X., Bai, Y., Han, X., Kim, H., He, Q., Wan, M., Shi, F., Feng, X., Liu, D., Huang, J*., Songyang, Z*. (2015). Actl6a protects embryonic stem cells from differentiating into primitive endoderm. Stem cells 33, 1782-1793. IF: 5.9

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