郭金虎 - 中山大学 - 生命科学学院

个人简介

2005. 9 – 2010.5 美国达拉斯德州大学西南医学中心生理系，博士后 2005. 3 - 2005. 9 美国芝加哥大学神经生物学、药物学和生理学系，博士后 1999. 8 - 2001. 6 南京医科大学江苏省生殖医学重点实验室，研究实习员、助理研究员教育经历： 2001. 9 – 2004. 6 复旦大学生命科学学院遗传学专业博士研究生，2004年6月获理学博士学位 1996. 9 – 1999. 6 南京师范大学生命科学院细胞生物学专业硕士研究生，1999年6月获理学硕士学位 1992. 9 - 1996. 6 南京师范大学生物系本科，1996年6月获理学学士学位

研究领域

实验室的方向为生物钟调控的规律及分子生物学机制研究。生物钟是地球上绝大多数生物为适应地球自转而产生的光照、温度等诸多环境因子的24小时周期性，而进化出来的内在的分子调控机制。生物钟对于调控生理、心理及行为的24小时周期具有重要意义，但生物节律受到干扰或破坏时，生理或健康会受损，包括会导致睡眠障碍、免疫力下降、代谢紊乱、情感性疾病以及导致肿瘤发生率增加等。除了24小时周期的节律外，不生物还存在潮汐节律、月节律、季节性节律等，这也都是对各种环境周期的适应，各自具有不同或交叉的分子调节基础。在这些不同的节律当中，目前研究得比较清楚的是24小时的昼夜节律，而对于其他节律的了解则得非常有限。

近期论文

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Wu Y#, Zhang Y#, Yu J, Wang P, Ma H, Chen S, Ma L, Zhang D, He Q, Guo J*. Up-Frameshift Protein UPF1 Regulates Neurospora crassa Circadian and Diurnal Growth Rhythms. Genetics. 206, 1881–1893. Cover story. Zhang L, Wan Y, Yu X, Huang G, Huang G, Guo J*. 2015 The exosome controls splicing events through mediating mRNA decay and gene expression, assembly and function of the spliceosome complex. Sci Rep. 5:13403. Wang P, Wang Z, Wang D, Tian Y, Li F, Zhang S, Guo Y, Liu W, Wang C, Chen S, Guo J*. 2015 Altered gravity simulated by parabolic flight and water immersion leads to decreased trunk motion. PLoS ONE. 10(7): e0133398. Liu Z, Wan Y, Zhang L, Wang D, Lv K, Wang C, Li Y, Chen X, Chen S, Guo J*. 2015 Alterations in heart rate and activity rhythms of three orbital astronauts on a space mission. Life Sciences in Space Research. 4:62-66. Guo J*, Qu W*, Chen S, Chen X, Lv K, Huang Z, Wu Y. 2014 Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Military Medical Research 1:23. (highly accessed paper). Xia X, Hu Y, Zhu H, Guo J, Guo X. 2014 The effects of gravity on sex hormones. A sponsored supplement to Science: Human performance in space - advancing astronautics research in China. 7-9. Wang D, Zhang L, Liang X, Shen H, Chen X, Wan Y, Guo J*. 2014 Space Meets Time: Impact of Gravity on Circadian/Diurnal Rhythms. A sponsored supplement to Science: Human performance in space - advancing astronautics research in China. 15-17. Liang X, Zhang L, Shen H, Chen X, Wan Y, Li L, Liang Y, Yu X, Guo Y, Yu J, Shu W, Tan C, Lv K, Xiao Y, Chen X, Chen S and Guo J*. 2014 Effects of a 45-day head-down bed rest on the diurnal rhythms of activity, sleep and heart rate. Biological Rhythm Research. 45(4): 596-601. Huang G, He Q, Guo J, Cha J, Liu Y. 2013 The Ccr4-not protein complex regulates the phase of the Neurospora circadian clock by controlling white collar protein stability and activity. J Biol Chem. 288(43):31002-31009. Wang D, Liang X, Chen X, Guo J*. 2013 Ribonucleoprotein Complexes that Control Circadian Clocks. Int. J. Mol. Sci.14:9018-9036. Zhou M, Guo J, Cha J, Chase M, Chen S, Barral JM, Sachs MS, Liu Y. 2013 Non-optimal codon usage determines the expression, structure and function of a circadian clock protein. Nature 495(7439):111-115. Liang X, Zhang L, Wan Y, Yu X, Guo Y, Chen X, Tan C, Huang T, Shen H, Chen X, Li H, Lv K, Sun F, Chen S, Guo J*. 2012 Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest. PLoS One. 7(10):e47984. Xue Z, Yuan H, Guo J, Liu Y. 2012 Reconstitution of an Argonaute-dependent small RNA biogenesis pathway reveals a handover mechanism involving the RNA exosome and the exonuclease QIP. Mol Cell. 46(3):299-310. Tao W, Chen S, Shi G, Guo J, Xu Y, Liu C. 2011. The SWI/SNF complex subunit BAF60a integrates hepatic circadian clock and energy metabolism. Hepatology 54:1414-1420. Zhang L, Weng W, Guo J*. 2011 Posttranscriptional mechanisms in controlling circadian rhythms. FEBS Letters 585: 1400-1405. Guo J, Liu Y. 2010 Molecular mechanism of Neurospora circadian oscillator. Protein & Cell 1(4):331-341. (Review) Guo J, Cheng P, Liu Y. 2010 Functional significance of FRH in regulating the phosphorylation and stability of the neurospora circadian clock protein FRQ. J Biol Chem 285: 11508-11515. Guo J, Cheng P, Yuan HY, Liu Y. 2009 The exosome regulates circadian gene expression in a posttranscriptional negative feedback loop. Cell 18: 1236-1246.