个人简介
B. S. in chemistry, Marietta College, Marietta OH, 1975
Ph.D. in organic chemistry, University of Wisconsin, Madison, WI, 1981
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Bunce, R. A.; Herron, D. M.; Johnson, L. B.; Kotturi, S. V. "Diastereoselective synthesis of substituted tetrahydroquinoline-4-carboxylic esters by a tandem reduction-reductive amination reaction," J. Org. Chem. 2001, 66, 2822-2827.
Bunce, R. A.; Schammerhorn, J. E.; Slaughter, L. M. "Catalyst and pressure dependent reductive cyclizations for the synthesis of hexahydropyrrolo[1,2-a]quinoline-5-carboxylic esters," J. Heterocyclic Chem. 2006, 43, 1505-1511.
Bunce, R. A.; Nago, T. "1-Alkyl-2,3-dihydro-4(1H)-quinolinones by a tandem Michael-SNAr annulation reaction," J. Heterocyclic Chem. 2009, 46, 623-628.
Bunce R. A.; Squires, S. T.; Nammalwar, B. "1-Alkyl- and (±)-1,2-dialkyl-2,3-dihydro-1,8-naphthyridine-4(1H)-ones by a tandem SNAr-Michael addition reactions," J. Org. Chem. 2013, 78, 2144-2148.
Bunce, R. A.; Lee, E. J. "Ester- and ketone-substituted (±)-1-alkyl-6-nitro-1,2,3,4-tetrahydroquinolines by a tandem SNAr-Michael reaction," J. Heterocyclic Chem. 2010, 47, 1176-1182.
Bunce, R. A.; Nammalwar, B. "1,2,3,9-Tetrahydro-4H-carbazol-4-one and 8,9-di-hydropyrido[1,2-a]indol-6(7H)-one from 1H-indole-2-butanoic acid," J. Heterocyclic Chem. 2009, 46, 172-177.
Bunce, R. A.; Lee, E. J.; Grant, M. T. "Ethyl 1,4-dihydro-4-oxo-3-quinoline-carboxylates by a tandem addition-elimination-SNAr reaction," J. Heterocyclic Chem. 2011, 48, 620-625.
Bunce, R. A.; Nammalwar, B. "Ethyl 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylates by a tandem addition-elimination-SNAr reaction," J. Heterocyclic Chem., 2012, 49, 658-663.
Bunce, R. A.; Schammerhorn, J. E. "Substituted 4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate esters by a tandem imine addition-SNAr reaction" J. Heterocyclic Chem. 2013, 50, 373-380.
Bunce, R. A.; Nammalwar, B. "New conditions for synthesis of (±)-2-monosubstituted and (±)-2,2-disubstituted 2,3-dihydro-4(1H)-quinazolinones from 2-nitro- and 2-amino-benzamide," J. Heterocyclic Chem. 2011, 48, 991-997.
Nammalwar, B.; Bunce, R. A.; Benbrook, D. M.; Lu, T.; Li, H.; Chen, Y.; Berlin, K. D. "Synthesis of N-[3,4-dihydro-4-(hydroxymethyl)-2,2,4-trimethyl-2H-1-benzo-thiopyran-6-yl]-N'-(4-nitrophenyl)thiourea, a major metabolite of N-(3,4-dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)-N'-(4-nitrophenyl)thiourea, Phosphorus Sulfur Silicon and the Related Elements 2011, 186, 189-204.
Nammalwar, B.; Berlin, K. D.; Bunce, R. A. "SHetA2—A mini-review of a promising anticancer drug," JSM Chem. 2013, 1, 1005.
Bourne, C. R.; Bunce, R. A.; Bourne, P. C.; Berlin, K. D.; Barrow, E. W.; Barrow, W. W. "Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity," Antimicrob. Agents Chemother. 2009, 53, 3065-3073.
Bourne, C. R.; Barrow, E. W.; Bunce, R. A.; Bourne, P. C.; Berlin, K. D.; Barrow, W. W. "Inhibition of antibiotic resistant Staphylococcus aureus by the broad‐spectrum dihydrofolate reductase inhibitor RAB1," Antimicrob. Agents Chemother. 2010, 54, 3825-3833.
Nammalwar, B.; Bunce, R. A.; Berlin, K. D.; Bourne, C. R.; Bourne, P. C.; Barrow, E.W.; Barrow,, W. W. "Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis" Eur. J. Med. Chem. 2012, 52, 387-396.
Bourne, C. R.; Wakeham, N.; Bunce, R. A.; Berlin, K. D.; Barrow, W. W. "Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets," J. Mol. Recognit. 2012, 25, 216-223.
Nammalwar, B.; Bourne, C. R.; Bunce, R. A.; Wakeham, N.; Bourne, P. C.; Ramnarayan, K.; Mylvaganam, S.; Berlin, K. D.; Barrow, E. W.; Barrow, W. W. "Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines," ChemMedChem 2012, 7, 1474-1482.
Bourne, C. R.; Wakeham, N.; Nammalwar, B.; Tseitin, V.; Bourne, P. C.; Barrow, E. W.; Ramnarayan, K.; Bunce, R. A.; Berlin, K. D., Barrow, W. W. "Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase," Biochem Biophys Acta, 2013, 1834, 46-52.