个人简介

B.A., 1955, North Central College Ph.D., 1958, University of Illinois

研究领域

Bioorganic Chemistry

Environmentally-relevant nanoparticles; nanoparticle detection/characterization techniques Novel materials Supramolecular assembly; molecular photophysics; fullerenes Carbon nanotubes; nanotechnology.

近期论文

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Liu, S.; Brown, C. W.; Berlin, K D.; Dhar, A.; Guruswamy, S.; Brown, D.; Benbrook, D. M. SYNTHESIS OF FLEXIBLE SULFUR-CONTAINING HETEROAROTINOIDS THAT INDUCE APOPTOSIS AND REACTIVE OXYGEN SPECIES WITH DISCRIMINATION BETWEEN MALIGNANT AND BENIGN CELLS. J. Med. Chem. 2004, 47, 999-1007. Brown, C. W.; Liu, S.; Klucik, J.; Berlin, K. D.; Brennan, P. J.; Kaur, D.; Benbrook, D. M. NOVEL HETERO-AROTINOIDS AS POTENTIAL ANTAGONISTS OF MYCOBACTERIUM BOVIS BCG. J. Med. Chem. 2004, 47, 1008-1017. Subramanian, S.; Smith, C. M.; Tabatabai, A.; Bryan, C. D.; Buettner, B.; Hale, S.; Wakefield, C. A.; Benbrook, D. M.; Berlin, K. D. SYNTHESES OF NOVEL HETEROAROTINOIDS WITH RECEPTOR ACTIVATION CAPABILITIES AND TGASE ACTIVITY. SINGLE CRYSTAL ANALYSIS OF (E)-4-[(2,3-DIHYDRO-2,2,4,4-TETRAMETHYL-2H-1-BENZO[b]THIOPYRAN-6-YL)-1-PROPENYL]-2-METHYLBENZOIC ACID. Phosphorus, Sulfur, and Silicon and The Related Elements 2005, 180, 67-77. Benbrook, D. M.; Kamelle, S. A.; Guruswamy, S. B.; Lightfoot, S. A.; Hannafon, B. N.; Rutledge, T. L.; Gould, N. S.; Dunn, S. T.; Berlin, K. D. FLEXIBLE HETEROAROTINOIDS (FLEX-HETS) EXHIBIT IMPROVED THERAPEUTIC RATIOS AS ANTI-CANCER AGENTS OVER RETINOIC ACID RECEPTOR AGONIST Investigational New Drugs. 2005, 23, 417-428. Le, T. C.; Berlin, K. D.; Benson, S. D.; Nelson, A. C.; Benbrook, D. M.; Eastman, M.; Bell-Eunice, G. UNUSUAL HETEROAROTINOIDS WITH ANTI-CANCER ACTIVITY AGAINST OVARIAN CANCER CELLS. Open Medicinal Chemistry. 2007, 1, 11-23. Lin, Yi-D; Chen, S.; Yue, P.; Zou, W.; Benbrook, D. M.; Liu, S.; Le, T. C.; Berlin, K. D.; Khuri, F. R.; Sun, S.-Y. CAAT/ENHANCER BINDING PROTEIN HOMOLOGOUS PROTEIN-DEPENDENT DEATH RECEPTOR 5 INDUCTION IS A MAJOR COMPONENT OF SHetA2-INDUCED APOPTOSIS IN LUNG CANCER CELLS. Cancer Res. 2008, 68, 5335-5344. Lin, Y.; Lui, X.; Yue, P.; Benrook, D. M.; Berlin, K.D.; Khuri, F. R.; Sun, S.-Y. INVOLVEMENT OF c-FLIP AND SURVIVING DOWN-REGULATION IN FLEXIBLE HETEROAROTINOI-INDUCED APOPTOSIS IN LUNG CANCER CELLS. Molecular Cancer Therapeutics. 2008, 7, 3556-3565. Liu, T.; Masamha, C. Chengedza, S.; Berlin, K. D.; Lightfoot, S.; He, F.; Benbrook, D. M. DEVELOPMENT OF FLEXIBLE-HETEROAROTINOIDS (FLEX-HETS) FOR KIDNEY CANCER. Molecular Cancer Therapeutics. 2009, 8, 1227-1238. Nammalwar, B.; Bunce, R. A.; Benbrook, D. M.; Lu, T.; Li, Hui-Fang; Ya-Dong, C.; Berlin, K. D. SYNTHESIS OF N-[3,4-DIHYDRO-4-(HYDROXYMETHYL)-2,2,4-TRIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL]-N’-(4-NITRO-PHENYL)THIOUREA, A MAJOR METAB-OLITE OF N-{3,4-DIHYDRO-2,2,4,4-TETRAMETHYL-2H-1- BENZO-THIOPYRAN-6-YL)-N’-(4-NITROPHENYL)THIOUREA. Phosphorus, Sulfur, and Silicon and The Related Elements. 2011, 186, 189-204 Bourne, C. R.; Bunce, R. A.; Bourne, P. C.; Berlin, K. D.; Barrow, E. W.; Barrow, W. W. CRYSTAL STRUCTURE OF Bacillus anthracis DIHYDROFOLATE REDUCTASE WITH THE DIHYDROPHTHALAZINE-BASED TRIMETHOPRIM-DERIVATIVES RAB1 PROVIDES A STRUCTURAL EXPLANATION OF POTENCY AND SELECTIVITY. Antimicrobial Agents And Chemotherapy. 2009, 53, 3065-3073. Bourne, A. R.; Bunce, R. A.; Barrow, E. W.; Bourne, P. C.; Berlin, K. D.; Barrow, W. W. Bourne, A. R. INHIBITION OF ANTIBIOTIC RESISTANT STAPHYLOCOCCUS AUREUS BY THE BROAD-SPECTRUM DIHYDROFOLATE REDUCTASE INHIBITOR RAB1. Antimicrobial Agents And Chemotherapy. 2010, 54, 3825-3833.