于霞 - 中南大学 - 湘雅药学院

个人简介

教育和工作经历 2003/9–2007/7，北京大学，药学院，学士 2007/9–2009/7，北京大学，药学院，硕士 2009/10–2013/9，马尔堡大学，药学院，博士 2013/12-2014/12，肯塔基大学，药学院，博士后 2015/1-2016/6，加州大学洛杉矶分校，化学与生物分子工程学院，博士后

研究领域

1，微生物来源重要次生代谢产物的生物合成研究 2，新颖生物合成酶催化机理研究 3，基于药物靶标的次生代谢产物的基因组挖掘 4，高效生物酶合成法和生物转化法的构建。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] X. Yu, F. Liu, Y. Zou, M. Tang, L. Hang, K. N. Houk, and Y. Tang. Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A, Journal of the American Chemical Society, 2016, 138, 13529–13532. (影响因子：13.038) [2] X. Yu,G. Zocher, X. Xie, M. Liebhold, S. Schütz, T. Stehle, and S.-M. Li. Catalytic mechanism of stereospecific formation ofcis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases, Chemistry & Biology, 2013, 20, 1492-1501. [3] S. Yin#,X. Yu#(并列一作), Q. Wang, X. Liu, and S.-M. Li. Identification of a brevianamide F reverse prenyltransferase BrePT fromAspergillus versicolorwith a broad substrate specificity towards tryptophan-containing cyclic dipeptides, Applied Microbiology and Biotechnology, 2013, 97, 1649-1660. [4] X. Yu, Y. Liu, X. Xie, X. Zheng, and S.-M. Li. Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophansynthase fromAspergillus clavatus, Journal of Biological Chemistry, 2012, 287, 1371-1380. [5] X. Yu, A. Yang, W. Lin, and S.-M. Li. Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases fromAspergillus, Tetrahedron Letters, 2012, 53, 6861-6864. [6] X. Yuand S.-M. Li, Prenyltransferases of the dimethylallyltryptophan synthase superfamily, Methods in Enzymology, 2012, 516, 259-278. [7] X. Yu, and S.-M. Li. Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS fromAspergillus fumigatus, Chembiochem, 2011, 12, 2280-2283. [8] X. Yu, X. Xie, and S.-M. Li. Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases, Applied Microbiology and Biotechnology, 2011, 92, 737-748. [9] W. Yin#,X. Yu#(并列一作), X. Xie, and S.-M. Li. Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT, Organic & Biomolecular Chemistry, 2010, 8, 2430-2438.