研究领域

Biophysical/Chemical Biology/Organic

The Aye Lab uses a unique blend of synthetic methodology, mechanistic biochemistry & mammalian cell biology as research toolkit.

近期论文

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Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells Xinqiang Fang#, Yuan Fu#, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez, and Yimon Aye*. Journal of the American Chemical Society 2013 135 14496-9 (#co-first authors) Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase Yuan Fu#, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing, and Yimon Aye*. Biochemistry 2013 52 7050-9 A fluorimetric readout reporting the inhibitor-induced human ribonucleotide reductase oligomerization Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing, and Yimon Aye*. ChemBioChem 2014 Accepted (doi:10.1002/cbic.201402368) Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert S. Weiss* Oncogene 2014 Accepted (doi: 10.1038/onc.2014.155) Mechanistic Studies of Semicarbazone Triapine Targeting Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen Species Yimon Aye, Marcus J. C. Long and JoAnne Stubbe*. Journal of Biological Chemistry 2012, 287, 35768. Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe*; Chemistry and Biology 2012, 19, 799. Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by Altering the Quaternary Structure of its Large Subunit Yimon Aye and JoAnne Stubbe*; Proceedings to the National Academy of Sciences USA (Direct Submission) 2011, 108, 9815. “Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long and Yimon Aye*; Chemistry, A European Journal 2009, 15, 5402. “Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” Richard J. Staples* and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49. “Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606. “Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034. “Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide. Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A. Evans*, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071. “Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald*; Proceedings to the National Academy of Sciences USA, 2004, 101, 5821.