Withers, Stephen G - University of British Columbia

个人简介

B.Sc., Bristol (1974); Ph.D., Bristol (M.L. Sinnott, 1977); Postdoctoral, Alberta (N.B. Madsen and B.D. Sykes, 1978-82); Fellow of the Chemical Institute of Canada; Merck, Sharpe and Dohme Award of the CIC (1989); Corday Morgan Medal of the Royal Society of Chemistry (1990); Rutherford Medal, Royal Society of Canada (1992), Khorana Chair of Biological Chemistry, UBC (1997), Hoffman LaRoche Award of the Canadian Society for Chemistry, 1998, Charmian Medal of the Royal Society of Chemistry, U.K., 2001, Whistler Award, International Carbohydrate Organisation, 2002. Scientific Director of the Protein Engineering Network of Centres of Excellence (PENCE)2000-05; Jacob Biely Faculty Research Prize (UBC) 2005; Finalist, NSERC Herzberg Award 2010; R.U. Lemieux Award for Research in Organic Chemistry (CSC) 2011; Director, Centre for High-Throughput Biology (CHiBi) 2008 - present; Canada Research Chair in Chemical Biology, 2008 - present; Fellow of the Royal Society of London, 2012, Centenery Prize Royal Society of Chemist, 2012, Killam Research Fellowship, The Canada Council for the Arts 2014-2016.

研究领域

Our interests focus primarily upon enzymes that catalyse glycoside formation and hydrolysis, since these play crucial roles in all areas of biology. Applications of our research (see below) range from the development of new catalysts for industrial processes to the design, synthesis and testing of new therapeutics.

近期论文

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Macdonald, S. S. ; Patel, A. ; Larmour, V. L. C. ; Morgan-Lang, C. ; Hallam, S. J. ; Mark, B. L. ; Withers, S. G. Structural And Mechanistic Analysis Of A Beta-Glycoside Phosphorylase Identified By Screening A Metagenomic Library. Journal of Biological Chemistry 2018, 293, 3451-3467.BibTex Saxena, H. ; Hsu, B. ; de Asis, M. ; Zierke, M. ; Sim, L. ; Withers, S. G. ; Wakarchuk, W. Characterization Of A Thermostable Endoglucanase From Cellulomonas Fimi Atcc484. Biochemistry and Cell Biology 2018, 96, 68–76.BibTex Weber, P. ; Nasseri, S. A. ; Pabst, B. M. ; Torvisco, A. ; Müller, P. ; Paschke, E. ; Tschernutter, M. ; Windischhofer, W. ; Withers, S. G. ; Wrodnigg, T. M. ; , Potent Gh20 N-Acetyl-$\beta$-D-Hexosaminidase Inhibitors: N-Substituted 3-Acetamido-4-Amino-5-Hydroxymethyl-Cyclopentanediols. Molecules 2018, 23, 708.BibTex Hettle, A. G. ; Vickers, C. ; Robb, C. S. ; Liu, F. ; Withers, S. G. ; Hehemann, J. - H. ; Boraston, A. B. The Molecular Basis Of Polysaccharide Sulfatase Activity And A Nomenclature For Catalytic Subsites In This Class Of Enzyme. Structure 2018.BibTex Smirnova, I. ; Kasho, V. ; Jiang, X. ; Chen, H. - M. ; Withers, S. G. ; H Kaback, R. Oversized Galactosides As A Probe For Conformational Dynamics In Lacy. Proceedings of the National Academy of Sciences 2018, 115, 4146–4151.BibTex Danby, P. M. ; Withers, S. G. Glycosyl Cations Versus Allylic Cations In Spontaneous And Enzymatic Hydrolysis. Journal of the American Chemical Society 2017, 139, 10629-10632.BibTex Centko, R. M. ; Ratnaweera, P. B. ; Tysoe, C. ; Withers, S. G. ; E de Silva, D. ; Andersen, R. J. Alpha-Glucosidase And Alpha-Amylase Inhibiting Thiodiketopiperazines From The Endophytic Fungus Setosphaeria Rostrata Isolated From The Medicinal Plant Costus Speciosus In Sri Lanka. Phytochemistry Letters 2017, 22, 76–80.BibTex Lizak, C. ; Worrall, L. J. ; Baumann, L. ; Pfleiderer, M. M. ; Volkers, G. ; Sun, T. ; Sim, L. ; Wakarchuk, W. ; Withers, S. G. ; Strynadka, N. C. J. X-Ray Crystallographic Structure Of A Bacterial Polysialyltransferase Provides Insight Into The Biosynthesis Of Capsular Polysialic Acid. Scientific Reports 2017, 7, 5842.BibTex Santana, A. G. ; Tysoe, C. ; Hu, G. ; Kronstad, J. ; Goddard-Borger, E. D. ; Withers, S. G. Fungal Glycolipid Hydrolase Inhibitors And Their Effect On Cryptococcus Neoformans. ChemBioChem 2017, 18, 284–290.BibTex Gao, Z. ; Niikura, M. ; Withers, S. G. Ultrasensitive Fluorogenic Reagents For Neuraminidase Titration. Angewandte Chemie International Edition. In Press, accepted Jan 24 2017 2017, 56, 6112-6116.BibTex Mageroy, M. H. ; Jancsik, S. ; Yuen, M. M. S. ; Fischer, M. ; Withers, S. G. ; Paetz, C. ; Schneider, B. ; MacKay, J. J. ; Bohlmann, J. A Conifer Udp-Sugar Dependent Glycosyltransferase Contributes To Acetophenone Metabolism And Defense Against Insects. Plant physiology 2017, 175, 641-651.BibTex Schalli, M. ; Wolfsgruber, A. ; Santana, A. Gonzalez; Tysoe, C. ; Fischer, R. ; Stütz, A. E. ; Thonhofer, M. ; Withers, S. G. C-5A-Substituted Validamine Type Glycosidase Inhibitors. Carbohydrate Research 2017, 440-441, 1–9.BibTex Jongkees, S. A. K. ; Caner, S. ; Tysoe, C. ; Brayer, G. D. ; Withers, S. G. ; Suga, H. Rapid Discovery Of Potent And Selective Glycosidase-Inhibiting De Novo Peptides. Cell Chemical Biology 2017, 24, 381–390.BibTex Armstrong, Z., R. P. ; Withers, S. G. Discovery Of New Glycosidases From Metagenomic Libraries. Methods Enzymol. In press. 2017, 597, 3-23.BibTex Lebl, R. ; Thonhofer, M. ; Tysoe, C. ; Pabst, B. M. ; Schalli, M. ; Weber, P. ; Paschke, E. ; Stütz, A. E. ; Tschernutter, M. ; Windischhofer, W. ; Withers, S. G. A Morita-Baylis-Hillman Based Route To C-5A-Chain-Extended 4-Epi-Isofagomine Type Glycosidase Inhibitors. Carbohydrate Research 2017, 442, 31–40.BibTex Strazzulli, A. ; Cobucci-Ponzano, B. ; Carillo, S. ; Bedini, E. ; Corsaro, M. Michela; Pocsfalvi, G. ; Withers, S. G. ; Rossi, M. ; Moracci, M. Introducing Transgalactosylation Activity Into A Family 42 $\upbeta$-Galactosidase. Glycobiology 2017, 27, 425–437.BibTex Kuatsjah, E. ; Chen, H. - M. ; Withers, S. G. ; Eltis, L. D. Characterization Of An Extradiol Dioxygenase Involved In The Catabolism Of Lignin-Derived Biphenyl. FEBS} Letters 2017, 591, 1001–1009.BibTex Kötzler, M. P. ; McIntosh, L. P. ; Withers, S. G. Refolding The Unfoldable: A Systematic Approach For Renaturation Of Bacillus Circulans Xylanase. Protein Science 2017, 26(8), 1555-1563.BibTex Schalli, M. ; Tysoe, C. ; Fischer, R. ; Pabst, B. M. ; Thonhofer, M. ; Paschke, E. ; Rappitsch, T. ; Stütz, A. E. ; Tschernutter, M. ; Windischhofer, W. ; , N-Substituted 5-Amino-1-Hydroxymethyl-Cyclopentanetriols: A New Family Of Activity Promotors For A G M1-Gangliosidosis Related Human Lysosomal $\beta$-Galactosidase Mutant. Carbohydrate Research 2017, 443-444, 15–22.BibTex Li, Z. ; Fischer, M. ; Satkunarajah, M. ; Zhou, D. ; Withers, S. G. ; Rini, J. M. Structural Basis Of Notch O-Glucosylation And O–Xylosylation By Mammalian Protein–O-Glucosyltransferase 1 (Poglut1). Nature Communications 2017, 8, 185.BibTex Duo, T. ; Robinson, K. ; Greig, I. R. ; Chen, H. - M. ; Patrick, B. O. ; Withers, S. G. Remarkable Reactivity Differences Between Glucosides With Identical Leaving Groups. Journal of the American Chemical Society 2017, 139, 15994–15999.BibTex