高志增 - 中山大学 - 海洋科学学院

个人简介

高志增，本科毕业于山东大学。2008到2013年在加拿大阿尔伯塔大学John Vederas 教授课题组（英国皇家院士，Fellow of the Royal Society）攻读博士学位，主要研究天然产物的生物合成，在JACS, Nature Chem Bio等期刊发表论文多篇。2013年，加入英属哥伦比亚大学Steve Withers 教授组（英国皇家院士，Fellow of the Royal Society），从事博士后研究。在博后期间发展了多种流感病毒神经氨酸酶荧光探针（Angew 2017, Angew 2018，US Patent 16/257,920）。之后发展了“FP tag”高通量糖基转移酶活性测试方法，并通过高通量筛选发现了两个海洋来源的Kdo 糖基转移酶抑制剂（JACS 2019）。之后和加拿大医药研究中心（CDRD）合作，筛选了一个包含15万化学物的商业化合物库，找出多个Kdo 糖基转移酶抑制剂。2018年，加入中山大学海洋学院，

研究领域

主要的研究方向是海洋天然产物的基因挖掘以及其药物化学应用。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhizeng Gao*, Olga G. Ovchinnikova, Bo Shun Huang, Dave Williams, Feng Liu, Todd Lowary, Chris Whitfield, Raymond J Andersen and Stephen G Withers*. A High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors. Journal of the American Chemical Society, 2018, In Press (*co-corresponding author) Zhizeng Gao, Andrew J. Thompson, James C. Paulson and Stephen G. Withers. Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases. Angewandte Chemie International Edition, 2018, 57, 13538-13541 (VIP paper) Zhizeng Gao, MasaHiro Niikura, Stephen G. Withers. Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration. Angewandte Chemie International Edition, 2017, 56, 6112-6116 Ralph A. Cacho, Justin Thuss, Wei Xu, Randy Sanichar, Zhizeng Gao, Allison Nguyen, John C. Vederas, and Yi Tang. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin LovB Megasynthase. Journal of the American Chemical Society, 2015, 135, 15688–15691. Rachel V. K. Cochrane#, Zhizeng Gao#, Gareth R. Lambkin, Wei Xu, Jaclyn M. Winter, Sandra L. Marcus, Yi Tang,and John C. Vederas. Comparison of 10,11-Dhydrocurvularin polyketide synthases from Alternaria cinerariae and Aspergillus terreus highlights key structural motifs. ChemBioChem, 2015, 16, 2479-2483 (#equal contribution, VIP paper) S.-H. Sheldon Tai, Olga Agafitei, Zhizeng Gao, Richard Liggins, Stephen G. Withers, Masahiro Niikura. Difluorosialic acid, a potent novel influenza virus neuraminidase inhibitor, induces fewer drug-resistant neuraminidase mutations than Oseltamivir. Virus Research, 2015, 210, 126-132 Zhizeng Gao#, Jingjing Wang#, Amy K. Norquay, Kangjian Qiao, Yitang, John C. Vederas. Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. Journal of the American Chemical Society, 2013, 135, 1735-1738 （#equal contribution, featured in JACS spotlight) Bryan Pyle, Hue Tran, Benjamin Pickel; Tegan Haslam; Zhizeng Gao, Gillian MacNevin, John C. Vederas, Dae-Kyun Ro. Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). FEBS Journal, 2012, 279, 3136-3146 Hui Zhou#, Zhizeng Gao#, Kangjian Qiao, Jingjing Wang, John C. Vederas, Yi Tang. A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology, 2012, 8, 331-333 (#equal contribution, Cover Story) Hui Zhou#, Kangjian Qiao#, Zhizeng Gao#, John C. Vederas, Yi Tang. Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. Journal of Biological Chemistry, 2010, 285, 41412-41421. (#equal contribution) Hui Zhou, Kangjian Qiao, Zhizeng Gao, Michael J. Meehan, Jesse W.-H. Li, Xiling Zhao, Pieter C. Dorrestein, John C. Vederas, Yi Tang. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society, 2010, 132, 4530-4531