Cannon, Jeffrey - Occidental College, OXY

个人简介

B.A. Occidental College; Ph.D. University of California, Irvine

研究领域

The core of all organic molecules is made up of carbon-carbon bonds. Our group is interested in developing new methods for their construction. To accomplish this, we analyze interesting and complex targets to design creative and highly efficient methods for their synthesis. We are particularly interested in methods that can accomplish this catalytically and stereoselectively. Our studies are augmented by utilizing computational methods to help predict and explain experimental results.

近期论文

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Shao-Xiong Luo, Jeffrey S. Cannon, Buck L. H. Taylor, Keary M. Engle, K. N. Houk, Robert H. Grubbs; "Z-Selective Cross-Metathesis and Homodimerization of 3E-1,3-Dienes: Reaction Optimization, Computational Analysis, and Synthetic Applications," J. Am. Chem. Soc. 2016, ASAP, doi: 10.1021/jacs.6b08387 Jeffrey S. Cannon, Larry E. Overman; "Palladium(II)-Catalyzed Enantioselective Reactions Using COP Catalysts," Acc. Chem. Res. 2016, ASAP. doi: 10.1021/acs.accounts.6b00398 Jeffrey S. Cannon, Lufeng Zou, Peng Liu, Yu Lan, Daniel J. O'Leary, K. N. Houk, Robert H. Grubbs; "Carboxylate-Assisted C(sp3)-H Activation in Olefin Metathesis-Relevant Ruthenium Complexes." J. Am. Chem. Soc. 2014, 136, 6733-6743. doi: 10.1021/ja5021958 Jeffrey S. Cannon, Robert H. Grubbs; “Alkene Chemoselectivity in Ruthenium-Catalyzed Z?Selective Olefin Metathesis,” Angew. Chem., Int. Ed. 2013, 52, 9001–9004. doi: 10.1002/anie.201302724 Jeffrey S. Cannon, Angela C. Olson, Larry E. Overman; “Palladium(II)-Catalyzed Enantioselective Synthesis of 2-Vinyl Oxygen Heterocycles,” J. Org. Chem. 2012, 77, 1961–1973. doi: 10.1021/jo202553a Jeffrey S. Cannon, James H. Frederich, Larry E. Overman; “Palladacyclic Imidazoline-Naphthalene Complexes: Synthesis and Catalytic Performance in Pd(II)-Catalyzed Enantioselective Reactions of Allylic Trichloroacetimidates,” J. Org. Chem. 2012, 77, 1939–1951. doi: 10.1021/jo2025724 Jeffrey S. Cannon, Larry E. Overman; “Is There No End to the Total Syntheses of Strychnine? Lessons to be Learned for Strategy and Tactics in Total Synthesis,” Angew. Chem., Int. Ed. 2012, 51, 4288–4311. doi: 10.1002/anie.201107385 Jeffrey S. Cannon, Stefan F. Kirsch, Larry E. Overman; “Catalytic Asymmetric Synthesis of Chiral Allylic Esters,” J. Am. Chem. Soc. 2010, 132, 15185–15191. doi: 10.1021/ja106685w Jeffrey S. Cannon, Stefan F. Kirsch, Larry E. Overman, Helen F. Sneddon; “Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters,” J. Am. Chem. Soc. 2010, 132, 15192–15203. doi: 10.1021/ja106688j