个人简介

Education 1983 B.S. University of Science and Technology of China (Chemistry/Polymer Sciences) 1990 M.S. University of Nebraska (Chemistry/Biochemistry) 1992 Ph.D. University of Nebraska (Chemistry/Molecular Biology) Positions and Employment 1993-1994 Post-doctoral fellow, Department of Chemistry, University of Nebraska, Lincoln, NE 1994-1996 Research Associate, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 1996-2003 Assistant research scientist, Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, MI 2003- Principal Investigator, Edison Biotechnology Institute, Ohio University, Athens, OH 2003-2011 Associate Professor, Department of Chemistry and Biochemistry, Ohio University, Athens, OH 2011- Professor, Department of Chemistry and Biochemistry, Ohio University, Athens, OH 2012- Director, Edison Biotechnology Institute, Ohio University, Athens, OH

研究领域

Biochemistry

1. Radiation (UVR and IR)-induced, ROS/RNS (O2•−, OH•, NO•, ONOO− et al)-mediated regulation of translation (EIF2AK activation and eIF2 alpha phosphorylation), ER-stress, NF-kappaB activation, apoptosis and autophagy. 2. Radiation (UVR and IR)-induced, membrane raft domains-mediated redistribution/aggregation of cell surface protein, cell-cell interaction and apoptosis. 3. Identification and characterization of natural and synthetic chemicals and small peptides for chemoprevention, radio-sensitization/protection and improvement of innate immune response.

近期论文

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Lingying Tong#, Ye Yuan# and Shiyong Wu*. Therapeutic microRNAs targeting the NF-kappa B Signaling Circuits of Cancers. (Review) Adv Drug Deliv Rev. 2014 (Accepted). Xiaozhuo Chen, Yanrong Qian, Shiyong Wu*. The Warburg Effect: Evolving Interpretations Of An Established Concept. (Review) Free Radical Biology & Medicine. 2014 (Accepted). Zheng, Qiuling; Zhang, Hao; Tong, Lingying; Wu, Shiyong; Chen, Hao*. A New Cross-Linking Electrochemical Mass Spectrometry for Probing Protein 3D-Structures. Anal. Chem. 2014 Aug 20. [Epub ahead of print] PubMed Lingying Tong and Shiyong Wu*. The Role of Constitutive Nitric Oxide Synthase in UVB-induced NF-κB Activity. J. Biol. Chem. 2014 Aug. 8. [Epub ahead of print] PubMed Lingying Tong and Shiyong Wu*. ROS and p53 in Regulation of UVB-induced hdm2 Alternative Splicing. Photochem. & Photobio. 2014 Jun 2. [Epub ahead of print] PubMed Yanrong Qian, Xuan Wang, Yi Liu, Yunsheng Li, Robert Colvin, Lingying Tong, Shiyong Wu, Xiaozhuo Chen*. Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells. Cancer Letter 2014 Sep 1;351(2):242-51. PubMed Huiwen Cheng, Lei Wang, Molly Mollica, Anthony T. Re, Shiyong Wu*, and Li Zuo*. Nitric oxide in cancer metastasis. (Review) Cancer Letter 2014 Jul 29. [Epub ahead of print] PubMed Lingying Tong and Shiyong Wu*. ROS and p53 in Regulation of UVB-induced hdm2 Alternative Splicing. Photochem. & Photobio. (2014) Jul 2. [Epub ahead of print] PubMed Ye Yuan, Michelle L Duff, Dawn L Sammons*, Shiyong Wu. Retrospective chart review of skin cancer presence in the wide excisions. World J Clin Cases (2014) March 16; 2(3): 52-56. PubMed Shin Hee Lee, Huiwen Cheng, Ye Yuan, and Shiyong Wu*. Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin. Radiation Research (2014) Jun;181(6):650-8. PubMed Weiwei Yuan, Xuelin Zhang, Yu Xu, Shasha Li, Yide Hu*, and Shiyong Wu*. Role Of HOXB7 In Regulation Of Progression And Metastasis Of Human Lung Adenocarcinoma. Mol. Carcinogenesis 53:49–57 (2014). PubMed Oliver L. Carpenter and Shiyong Wu*. Regulation of MSK-1-mediated NF-kB Activation Upon UVB Irradiation. Photochem. & Photobio. (2014). 90: 155-61. PubMed. Huiwen Cheng, Shin Hee Lee and Shiyong Wu*. Effects Of LNAC On Adhesive Strength Between Breast Cancer Cell and Extracellular Matrix Proteins Upon Ionizing Radiation. Life Sciences (2013) 13;93(21):798-803 PubMed Ye Yuan, Shin Hee Lee and Shiyong Wu*. The Role Of ROS In Ionizing Radiation-Induced VLA-4 Mediated Adhesion Of RAW264.7 Cells To VCAM-1 Under Flow Conditions. Radiation Research (2013) 179, 62–68. PubMed Lu W and Wu S*. Mechanism for Dynamic Regulation of iNOS Expression After UVB-Irradiation. Mol. Carcinogenesis (2013) 52(8):627-33. PubMed Huiwen Cheng, Molly Y. Mollica, Shin Hee Lee, Lei Wang, Carlos A. Velázquez-Martínez* and Shiyong Wu*. Effects of Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs (NONO-NSAIDs) on Melanoma Cell Adhesion. Toxicol Appl Pharmacol. (2012) Oct 15;264(2):161-6. PubMed Liu Y, Cao Y, Zhang W, Bergmeier SC, Qian Y, Akbar H, Colvin RA, Ding J, Tong L, Wu S, Hines JV, and Chen X*. A small molecule inhibitor of glucose transporter 1 down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol. Cancer Therapeutics (2012) Aug;11(8):1672-82. PubMed George KS, Elyassaki W, Wu Q and Wu S*. The Role of Cholesterol In Ultraviolet Light B-Induced Apoptosis. Photochem Photobio (2012) 88: 1191–1197. PubMed Wu Q and Wu S*. Lipid Rafts Association of Prohibitin And Its Role in Ultraviolet B Light -Induced Apoptosis. Exp. Dermatology (2012) Aug; 21(8):640-2. PubMed George KS and Wu S*. Lipid Raft: A Floating Island Of Death or Survival. (Invited Review) Toxicol Appl Pharmacol. (2012) 259(3): 311-319. PubMed