Chen, Xiaojiang - University of Southern California, USC

个人简介

B.S. , Shihezi University, China Ph.D. Biochemistry and Molecular Biology, Virology, University of California, Davis, 7/1992

近期论文

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Fu, Y., Slaymaker, I. M., Wang, J., Wang, G., Chen,Fu, X. S., Slaymaker, I. M., Wang, J., Wang, G., Chen, X. S. (2014). The 1.8-? crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament. J.M.B. (426:7), pp. 1512-23. PubMed Web Address Chang, Y. P., Xu, M., Machado, A. C., Yu, X. J., Rohs, R., Chen, X. S. (2013). Mechanism of origin DNA recognition and assembly of an initiator-helicase complex by SV40 large tumor antigen. Cell reports. Vol. 3 (4), pp. 1117-27. PubMed Web Address Patrick, A. N., Cabrera, J. H., Smith, A. L., Chen, X. S., Ford, H. L., Zhao, R. (2013). Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nature structural & molecular biology. Vol. 20 (4), pp. 447-53. PubMed Web Address Slaymaker, I. M., Fu, Y., Toso, D. B., Ranatunga, N., Brewster, A., Forsburg, S. L., Zhou, Z. H., Chen, X. S. (2013). Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. Nucleic acids research. Vol. 41 (5), pp. 3446-56. PubMed Web Address Asokan, R., Banda, N. K., Szakonyi, G., Chen, X. S., Holers, V. M. (2013). Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE). Molecular immunology. Vol. 53 (1-2), pp. 99-110. PubMed Web Address Wang, W., Nie, J., Prochnow, C., Truong, C., Jia, Z., Wang, S., Chen, X. S., Wang, Y. (2013). A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization. Retrovirology. Vol. 10, pp. 14. PubMed Web Address Gai, D., Chang, Y. P., Chen, X. S. (2010). Origin DNA melting and unwinding in DNA replication. Current opinion in structural biology. Vol. 20 (6), pp. 756-62. PubMed Web Address Brewster, A. S., Chen, X. S. (2010). Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex. Critical reviews in biochemistry and molecular biology. Vol. 45 (3), pp. 243-56. PubMed Web Address Shi, Y., Liu, H., Gai, D., Ma, J., Chen, X. S. (2009). A computational analysis of ATP binding of SV40 large tumor antigen helicase motor. PLoS computational biology. Vol. 5 (9), pp. e1000514. PubMed Web Address Liu, H., Shi, Y., Chen, X. S., Warshel, A. (2009). Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases. Proceedings of the National Academy of Sciences of the United States of America. Vol. 106 (18), pp. 7449-54. PubMed Web Address Chiang, A. N., Valderramos, J. C., Balachandran, R., Chovatiya, R. J., Mead, B. P., Schneider, C., Bell, S. L., Klein, M. G., Huryn, D. M., Chen, X. S., Day, B. W., Fidock, D. A., Wipf, P., Brodsky, J. L. (2009). Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & medicinal chemistry. Vol. 17 (4), pp. 1527-33. PubMed Web Address Brewster, A. S., Wang, G., Yu, X., Greenleaf, W. B., Carazo, J. M., Tjajadi, M., Klein, M. G., Chen, X. S. (2008). Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase. Proceedings of the National Academy of Sciences of the United States of America. Vol. 105 (51), pp. 20191-6. PubMed Web Address Holden, L. G., Prochnow, C., Chang, Y. P., Bransteitter, R., Chelico, L., Sen, U., Stevens, R. C., Goodman, M. F., Chen, X. S. (2008). Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature. Vol. 456 (7218), pp. 121-4. PubMed Web Address Wang, G., Klein, M. G., Tokonzaba, E., Zhang, Y., Holden, L. G., Chen, X. S. (2008). The structure of a DnaB-family replicative helicase and its interactions with primase. Nature structural & molecular biology. Vol. 15 (1), pp. 94-100. PubMed Web Address Chang, Y. P., Wang, G., Bermudez, V., Hurwitz, J., Chen, X. S. (2007). Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proceedings of the National Academy of Sciences of the United States of America. Vol. 104 (31), pp. 12685-90. PubMed Web Address Prochnow, C., Bransteitter, R., Klein, M. G., Goodman, M. F., Chen, X. S. (2007). The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature. Vol. 445 (7126), pp. 447-51. PubMed Web Address Bishop, B., Dasgupta, J., Chen, X. S. (2007). Structure-based engineering of papillomavirus major capsid l1: controlling particle assembly. Virology journal. Vol. 4, pp. 3. PubMed Web Address Szakonyi, G., Klein, M. G., Hannan, J. P., Young, K. A., Ma, R. Z., Asokan, R., Holers, V. M., Chen, X. S. (2006). Structure of the Epstein-Barr virus major envelope glycoprotein. Nature structural & molecular biology. Vol. 13 (11), pp. 996-1001. PubMed Web Address Lilyestrom, W., Klein, M. G., Zhang, R., Joachimiak, A., Chen, X. S. (2006). Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. Genes & development. Vol. 20 (17), pp. 2373-82. PubMed Web Address Shen, J., Gai, D., Patrick, A., Greenleaf, W. B., Chen, X. S. (2005). The roles of the residues on the channel beta-hairpin and loop structures of simian virus 40 hexameric helicase. Proceedings of the National Academy of Sciences of the United States of America. Vol. 102 (32), pp. 11248-53. PubMed Web Address