个人简介

Education Ph.D. (Analytical Chemistry), University of North Carolina, Chapel Hill, NC, 1988 Dissertation Advisor Thomas L. Isenhour B.S. (Chemistry), Randolph-Macon College, Ashland, VA, 1980 Professional Experience Director of the Forensic Chemistry Programs, 2012-present Visiting Scholar, Universitetet i Agder, Kristiansand, NO, August, 2010. Director of the Master of Science Program in Forensic Chemistry, 2009-present Chercheur Etranger, Université Paul Cézanne, Marseille, FR September-December, 2008. Summer Visiting Fellow (ORISE) Food and Drug Administration/Center for Food Safety and Applied Nutrition, MD, June-August, 2007 Summer Visiting Fellow (Contractor) National Institutes of Health/National Institute of Mental Health, Bethesda, MD, July-August, 2005 Director of the Forensic Chemistry Program, 2004-2009 Professor, Ohio University, 2004-Present Summer Visiting Fellow (Contractor) National Institutes of Health/National Institute of Child Health and Human Development, Bethesda, MD, July-August, 2004 Summer Faculty Fellow, Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID, June-July, 2003 Director, Ohio University Center for Intelligent Chemical Instrumentation, 2002- Present Faculty Fellow, Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID, 2001-2002 Associate Professor, Ohio University, 1995-2004 (Tenured 1995) Adjunct Professor Environmental Science, Ohio University, 1994-Present Assistant Professor, Ohio University, 1989-1995 Research Assistant Professor, The Colorado School of Mines, Golden, CO, 1988- 1989 Harrington 2 of 73 Research Associate, The Colorado School of Mines, Golden, CO, 1987-1988 Flavor Chemist, Nabisco Brands Inc., Wilton, CT, 1980-1982

研究领域

Analytical

The nature and significance of my scholarship is directed towards the development of intelligent chemical instruments. I am working with ion mobility spectrometry (IMS) and mass spectrometry (MS). These two methods are complementary and are distinguished by the pressure at which the ion measurement is made. If the ion velocities are measured in the gas phase at atmospheric pressure, the ion mobility is determined by an ion's volume-to-charge ratio. If the ions are measured under vacuum conditions (i.e., less than a millionth of atmospheric pressure) then their velocity is determined by the mass-to-charge ratio of the ion. Because ion mobility spectrometers do not require a vacuum system, they are more portable, less costly, more rugged, and amenable to miniaturization. Mass spectrometers have the advantages of greater resolving and informing power when compared to ion mobility spectrometers. My group is interested in coupling chemometric methods with ion mobility and mass spectrometers, so that the chemometric methods are transparent to the user and so that the instrument exhibits intelligent behavior. An intelligent instrument furnishes user- or problem-defined information as opposed to data that must be interpreted by a scientist. My group is developing algorithms that perform real-time signal processing, modeling, and interpretation. There are several application areas that interest us. We are developing methods for rapid identification of bacteria or biogenic compounds using IMS and MS. Our forensic projects involve improving the identification of drugs of abuse and explosives by IMS, as well as adapting IMS to new applications such as accelerant detection for arson cases. My group is studying and characterizing bacteria digests and whole-cell bacteria by matrix assisted laser desorption/ionization (MALDI)-MS. The mass spectral data is used to profile the bacterial proteins. My group has been actively involved in biomarker detection in MS data since 1990. Presently, we are investigating early diagnosis of disease from MS data as well as using MALDI-MS as a rapid forensic analysis tool.

近期论文

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Y. Mao, L. Yu*, J. Li, L. Qu*, and P.B. Harrington, A novel method for the study of molecular interaction by using microscale thermophoresis submitted to Talanta. L. Wang, R. Yang*, H. Wang, J. Li, L. Qu*, and P.B. Harrington, High-selective and sensitive voltammetric sensor for butylated hydroxyanisole based on AuNPs-PVP-graphene nanocomposites submitted to Talanta. N. Qi, Z. Zhang*, Y. Xiang, Y. Yang, X. Liang, and P.B. Harrington, Terahertz Time-domain Spectroscopy Combined with Support Vector Machines and Partial Least Squares Regression Applied to Early Diagnosis of Cervical Carcinoma submitted to Journal of Biomedical Optics. A.H. Bani Rashaid, P.B. Harrington*, and Glen P. Jackson Profiling Amino Acids of Jordanian Scalp Hair as a Tool for Diabetes Mellitus Diagnosis submitted to Analytical and Bioanalytical Chemistry. M. Zhang and P.B. Harrington*, Determination of Trichloroethylene in Water by Liquid-liquid Microextraction Assisted Solid Phase Microextraction, submitted to Chromatography. L. Wang, R. Yang*, J. Li, L. Qu, and P.B. Harrington, Template-directed self-assembly of graphene-quantum dots hybrid structure for Sudan I M. Jie, F. Yu, S. Yu, L. Qu, P.B. Harrington, and Y. Wu*, Study on Magnetic Enzyme Chemiluminescence Immunoassay Methods of Fumonisin B1 submitted to Biosensors and Bioelectronics. Y. Li, B. Xiang, Y. Zong, G. Tang, L. Qu, Y. Wu, and P.B. Harrington, Character Evaluation of the Routine Components and Volatile Components of Tobacco submitted to the 2014 International Conference on Computer Science and Software Engineering. A.H. Bani Rashaid, P.B. Harrington, and G.P. Jackson*, Amino Acid Composition of Human Scalp Hair as a Biometric Classifier and Investigative Lead. Analytical Methods (2014) DOI: 10.1039/C4AY02588A. N. Qi, Z. Zhang*, Y. Xiang, Y. Yang, and P.B. Harrington, Terahertz Time-domain Spectroscopy Combined with Fuzzy Rule-building Expert System and Fuzzy Optimal Associative Memory Applied to Early Diagnosis of Cervical Carcinoma. Medical Oncology 32:383 (2014) DOI: 10.1007/s12032-014-0383-z. K.J. Voorhees*, N.R. Saichek, K.R. Jensen, C.R. Cox, and P.B. Harrington, Comparison of Metal Oxide Catalysts for Pyrolytic MALDI-TOF MS Bacterial Identification. Journal of Analytical and Applied Pyrolysis (2014) DOI: 10.1016/j.jaap.2014.10.016. Z. Wang, L. Lin, J.M. Harnly, P.B. Harrington, and P. Chen*, Computer-aided method for identification of major flavone/flavonol glycosides by high-performance liquid chromatography-diode array detection-tandem mass spectrometry (HPLC-DAD-MS/MS). Analytical and Bioanalytical Chemistry 406 (2014) 7695-7704 DOI: 10.1007/s00216-014-8187-8. D. Miao, J. Li, R. Yang*, J. Qu, L. Qu, and P.B. Harrington, Supersensitive electrochemical sensor for the fast determination of rutin in pharmaceuticals and biological samples based on poly(diallyldimethylammonium chloride)-functionalized graphene. Journal of Electroanalytical Chemistry 732 (2014) 17-24 DOI: 10.1016/j.jelechem.2014.08.018. M. Zhang and P.B. Harrington*, Simultaneous Quantification of Aroclor Mixtures in Soil Samples by Gas Chromatography/Mass Spectrometry with Solid Phase Microextraction using Partial Least-Squares Regression. Chemosphere 118C (2014) 187-193, DOI: 10.1016/j.chemosphere.2014.08.018. Z. Wang, M. Zhang, and P.B. Harrington*, A Comparison of Three Algorithms for the Baseline Correction of Hyphenated Data Objects. Analytical Chemistry 86:18 (2014) 9050-9057, DOI: 10.1021/ac501658k. L. Wang, R. Yang*, J. Chen, J. Li, L. Qu*, and P.B. Harrington, Sensitive voltammetric sensor based on Isopropanol–Nafion–PSS–GR nanocomposite modified glassy carbon electrode for determination of Clenbuterol in pork. Food Chemistry 164 (2014) 113-118, DOI: 10.1016/j.foodchem.2014.04.052. A.H. Bani Rashaid, G.P. Jackson, and, P.B Harrington*, Validation of a Method of Measuring the Amino Acid Composition of Proteins by Gas Chromatography/Mass Spectrometry. Enliven: Bio Analytical Techniques 1(1):002 (2014), http://www.enlivenarchive.org/bioanalytical-002.pdf. M. Zhang, G.P. Jackson, N.A. Kruse, J.R. Bowman, and P.B. Harrington*, Determination of Aroclor 1260 in Soil Samples by GC-MS with Solid-Phase Microextraction. Journal of Separation Science 118 (2014) 187-193, DOI: 10.1002/jssc.201400102. J.M. Harnly*, P.B. Harrington*, L.L. Botros, J.E. Jablonski, C. Chang, M.M. Bergana, P. Wehling , G. Downey, A.R. Potts , and J.C. Moore, Characterization of Near Infrared Spectral Variance in the Authentication of Skim and Nonfat Dry Milk Powder Collection Using ANOVA-PCA, Pooled-ANOVA, and Partial Least Squares Regression. Journal of Agriculture and Food Chemistry 62:32 (2014) 8060-8067, DOI: 10.1021/jf5013727. J. Wang, Z. Zhang*, Z. Zhang, Y. Xiang, and P.B. Harrington, THz-TDS combined with a fuzzy rule-building expert system applied to identification of official rhubarb samples. Analytical Methods 6:19 (2014) 7695-7702, DOI: 10.1039/C4AY00555D.