个人简介

Ph.D., Massachusetts Institute of Technology, 1991 MSME, University of Belgrade, 1982 BSME, University of Belgrade, 1975

研究领域

Computational biology, cell and tissue mechanics, muscle biophysics, muscle biology, pulmonary physiology, physiology of cardiovascular system, rheology of polymers and biomaterials, physicochemical hydrodynamics

My current research focuses on the development of quantitative approaches to study biological systems at multiple levels of organization (i.e. multiscale modeling). In particular I am interested in developing a theoretical framework that will advance our understanding of how cellular and subcellular phenomena integrate to impact structure-function and dynamic relations of whole physiological systems, based on the kinetics of underlying molecular processes. My laboratory, established in fall 2003, focuses on the interplay between mechanical forces, cell biology, and integrated organ physiology. The central issues are: (1) how a cell actively develops mechanical forces, and how these forces affect chemical transitions (for example in the actomyosin ATPase cycle); (2) how a cell senses and responds to mechanical forces; and (3) how changes in protein-protein interactions of the cytoskeletal elements and accessory proteins inside the cell can affect cell or organ properties and their function. We bring to this research area an interdisciplinary approach that spans engineering science, computational science, biology, biochemistry, and biophysics. We combine molecular, cellular, and whole organ approaches in order to understand cell and tissue biology, muscle physiology, and whole organ physiology. A major effort over the last 10 years has been the development of the computational platform: MUSICO (Muscle Simulation Code). The interdisciplinary approach implemented in MUSICO allows researchers to unveil the molecular origins of physiological functions or dysfunctions of all muscle types: skeletal, cardiac, smooth and insect flight muscle. The platform integrates experimental data at multiple scales including cross bridge kinetics and regulation, structure of contractile proteins, interaction between the contractile proteins and their assembly in sarcomeres in striated muscle and sarcometric structures in smooth muscle. Experimentally determined parameters implemented in MUSICO are partially derived from data collected in our lab and partially via an international multi-institutional effort with several world-leading Universities. At larger length scales, the precise architecture of muscle at the organ level provided from diffusion tensor imaging (DTI) in concert with the MUSICO prediction of instantaneous active and passive characteristics of muscle provides a precise tool to trace the effects of molecular defects leading to impaired function of organs in disease. Currently developed applications of the MUSICO platform are studies of asthma and pulmonary hypertension, cardiomyopathies, muscle weakness and disorders of tongue function during swallowing.

近期论文

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Modelling the Calcium Dependent Actin-Myosin ATP-ase Cycle in Solution SM Mijailovich, D Nedic, M Svicevic, B Stojanovic, M Geeves Biophysical Journal 108 (2), 594a Activation and Relaxation Kinetics in Skeletal and Cardiac Muscles SM Mijailovich, B Stojanovic, D Nedic, MA Geeves Biophysical Journal 108 (2), 337a-338a Effect of Mutations in cMyBP-C on Sarcomere Mechanical Function D Nedic, M Svicevic, B Stojanovic, MA Geeves, T Irving, RJ Gilbert, ... Biophysical Journal 108 (2), 200a Estimation of Local Forces in Myofilaments using X-Ray Diffraction Patterns and Muscle Mechanics Data M Prodanovic, D Nedic, TC Irving, SM Mijailovich Biophysical Journal 108 (2), 422a-423a Multiscale model predictions of X-ray diffraction patterns from nonuniformly stretched actin filaments M Prodanovic, T Irving, B Stojanovic, SM Mijailovich Northeast Bioengineering Conference (NEBEC), 2014 40th Annual, 1-2 Effect of Nonlinear Crossbridge Elasticity on Kinetics of Sarcomeric Contraction SM Mijailovich, D Nedic, B Stojanovic, MA Geeves Biophysical Journal 106 (2), 158a X-Ray Diffraction Pattern of Non-Uniformly Stretched Actin Filament M Prodanovic, TC Irving, R McOwen, SM Mijailovich Biophysical Journal 106 (2), 768a Myosin Binding to Human Cardiac Thin Filaments Containing Tropomyosin Carrying DCM & HCM Mutations; Fitting of Complex Binding Transients M Svicevic, SM Mijailovich, M Janco, MA Geeves Biophysical Journal 106 (2), 769a Nonlinear Elasticity of a Crossbridge in Sarcomere Lattice B Stojanovic, M Svicevic, RJ Gilbert, SM Mijailovich Biophysical Journal 106 (2), 158a Modulation of Crossbridge Cycling Kinetics and Length Dependent Calcium Sensitivity by Titin and Nebulin SM Mijailovich, B Stojanovic, D Nedic, M Svicevic, RJ Gilbert, MA Geeves, ... Biophysical Journal 104, 310 Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm–Tn chain SM Mijailovich, O Kayser-Herold, X Li, H Griffiths, MA Geeves European Biophysics Journal 41 (12), 1015-1032 The hill model for binding myosin S1 to regulated actin is not equivalent to the Mckillop–Geeves model SM Mijailovich, X Li, RH Griffiths, MA Geeves Journal of molecular biology 417 (1), 112-128 Mechanoregulation of Delayed Stretch Activation SM Mijailovich, B Stojanovic, RJ Gilbert, T Irving Biophysical Journal 102 (3), 356a Biophysical and Biochemical Determinants of Contractile Force Generation, Regulation and Function SM Mijailovich Cell and Tissue Engineering, 44-91 Estimating parameters of a model of thin filament regulation in solution using genetic algorithms B Stojanovic, M Svicevic, D Nedic, M Ivanovic, SM Mijailovich Journal of the Serbian Society for Computational Mechanics/Vol 6 (1), 41-55 Cooperative [Ca 2+]-dependent regulation of the rate of myosin binding to actin: solution data and the tropomyosin chain model M Geeves, H Griffiths, S Mijailovich, D Smith Biophysical journal 100 (11), 2679-2687 Multiscale Model Predictions of X-Ray Diffraction Patterns in Contracting Skeletal Muscle SM Mijailovich, B Stojanovic, T Irving Biophysical Journal 100 (3), 585a Inter-Filament Distance In Smooth Muscle: Implications In The Structure Of Contractile Apparatus A Marinkovic, N Vujacic, V Vladimirov, CY Seow, SM Mijailovich Am J Respir Crit Care Med 183, A3644 Spatial and Temporal Patterns of Lingual Muscle Activation During Swallowing Based on a Finite Element (FE) Simulation Of Tissue Deformation Derived from the Mechanics of Mesoscale Myofiber Tracts R Gilbert, S Mijailovich DYSPHAGIA 25 (4), 369-370 Derivation of a finite-element model of lingual deformation during swallowing from the mechanics of mesoscale myofiber tracts obtained by MRI SM Mijailovich, B Stojanovic, M Kojic, A Liang, VJ Wedeen, RJ Gilbert Journal of Applied Physiology 109 (5), 1500-1514