个人简介
A.B., Bowdoin College, Biochemistry (1976)
Ph.D., MIT, Biochemistry (1982)
近期论文
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Heat shock response activation exacerbates inclusion body formation in a cellular model of huntington disease. journal of biological chemistryBersuker, K., Hipp, M. S., Calamini, B., Morimoto, R. I., Kopito, R. R.2013; 288 (33): 23633-23638
Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAOlzmann, J. A., Richter, C. M., Kopito, R. R.2013; 110 (4): 1345-1350
Simultaneous Measurement of Amyloid Fibril Formation by Dynamic Light Scattering and Fluorescence Reveals Complex Aggregation Kinetics PLOS ONEStreets, A. M., Sourigues, Y., Kopito, R. R., Melki, R., Quake, S. R.2013; 8 (1)
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics. PloS oneStreets, A. M., Sourigues, Y., Kopito, R. R., Melki, R., Quake, S. R.2013; 8 (1)
The Mammalian endoplasmic reticulum-associated degradation system. Cold Spring Harbor perspectives in biologyOlzmann, J. A., Kopito, R. R., Christianson, J. C.2013; 5 (9)
Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate MOLECULAR BIOLOGY OF THE CELLTyler, R. E., Pearce, M. M., Shaler, T. A., Olzmann, J. A., Greenblatt, E. J., Kopito, R. R.2012; 23 (24): 4668-4678
ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding DEVELOPMENTAL CELLDowlatshahi, D. P., Sandrin, V., Vivona, S., Shaler, T. A., Kaiser, S. E., Melandri, F., Sundquist, W. I., Kopito, R. R.2012; 23 (6): 1247-1254
Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD NATURE STRUCTURAL & MOLECULAR BIOLOGYGreenblatt, E. J., Olzmann, J. A., Kopito, R. R.2012; 19 (10): 979-981
Fibrillar Structure and Charge Determine the Interaction of Polyglutamine Protein Aggregates with the Cell Surface JOURNAL OF BIOLOGICAL CHEMISTRYTrevino, R. S., Lauckner, J. E., Sourigues, Y., Pearce, M. M., Bousset, L., Melki, R., Kopito, R. R.2012; 287 (35): 29722-29728
Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease JOURNAL OF CELL BIOLOGYHipp, M. S., Patel, C. N., Bersuker, K., Riley, B. E., Kaiser, S. E., Shaler, T. A., Brandeis, M., Kopito, R. R.2012; 196 (5): 573-587