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个人简介

张可教授于2009年在美国华盛顿大学路易斯分校获得博士学位,师从KarenWooley教授。博士毕业后加入美国西北大学ChadMirkin教授课题组从事博士后研究。2012年加入美国东北大学,现任美国东北大学化学与化学生物学学院副教授。其课题组长期致力于发展新型功能高分子材料及纳米生物材料,近几年来在JACS,Angew,Chem,PNAS等国际高水平期刊发表论文40余篇,并获得美国国家自然科学基金CAREER奖和美国化学会PMSE杰出青年研究员奖等。

近期论文

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Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* “Polycondensation of polymer brushes via DNA hybridization”, J. Am. Chem. Soc., 2014, 136, 10214 Zhang, K.;* Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. “Temperature-activated nucleic acid nanostructures”, J. Am. Chem. Soc., 2013, 135, 14102 Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-cylinder and disk-sphere nanoparticles from block copolymer blend solution construction”, Nat. Commun., 2013, doi:10.1038/ncomms3297 Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression levels in living cells with PNA∙DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles”, Org. Biomol. Chem., 2013, doi:10.1039/C3OB26923J Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J.; Welch, M. J.; Taylor, J.-S. A.; Wooley, K. L.; Brody, S. L. “PEGylation of cationic, shell-crosslinked knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung”, Nanomedicine NBM, 2013, doi:10.1016/j.nano.2013.02.006 Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.; Taylor, J.-S. A. “Efficient protection and transfection of small interfering RNA by cationic shell-crosslinked knedel-like nanoparticles”, Nuc. Acid Ther., 2013, doi:10.1089/nat.2012.0390 Wang, Z.; Zhang, K.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression in live cells via peptide nucleic acid (PNA) strand-displacement activated probes”, J. Nuc. Acids, 2012, doi:10.1155/2012/962652 Zhang, K.; Hao, L.; Hurst, S. J.; Mirkin, C. A. “Antibody-linked spherical nucleic acids for cellular targeting”, J. Am. Chem. Soc., 2012, 134, 16488–16491 Auyeung, E.; Cutler, J. I.; Macfarlane, R. J.; Jones, M. R.; Zhang, K.; Mirkin, C. A. “Synthetically programmable nanoparticle superlattices: The hollow three-dimensional spacer approach”, Nat. Nanotechnol., 2012, 7, 24-28 (Cover article; highlighted by MRS Bulletin) Zhang, K.; Zheng, D.; Hao, L.; Cutler, J. I.; Auyeung, E.; Mirkin, C. A. “ImmunoPods: Polymer shells with native antibody crosslinks”, Angew. Chem. Int. Ed., 2012, 5, 1169-1172 (Hot Paper) Pochan, D. J.; Zhu, J.; Zhang, K.; Wooley, K. L.; Miesch C.; Emrick, T. “Multicompartment and multigeometry nanoparticle assembly”, Soft Matter, 2011, 7, 2500-2506 Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. “Polyvalent nucleic acid nanostructures”, J. Am. Chem. Soc., 2011, 133, 9254-9257 (Equal first author; highlighted by C&EN and WTTW Chicago Tonight TV program) Zhang, K.; Cutler, J. I.; Zhang, J.; Zheng, D.; Auyeung, E.; Mirkin, C. A. “Nanopod formation through gold nanoparticle templated and catalyzed crosslinking of polymers bearing pendant propargyl ethers”, J. Am. Chem. Soc., 2010, 132, 15151-15153 Zhang, J.; Langille, M. R.; Personick, M. L.; Zhang, K.; Li, S.; Mirkin, C. A. “Concave cubic gold nanocrystals with high-index facets”, J. Am. Chem. Soc., 2010, 132, 14012-14014 Sun, G.; Berezin, M.; Fan, J.; Lee, H.; Ma, J. Zhang, K.; Wooley, K. L.; Achilefu, S. “Bright fluorescent nanoparticles for developing potential optical imaging contrast agents”, Nanoscale, 2010, 2, 548-558 Zhang, K.; Fang, H.; Wang, Z.; Li, Z.; Taylor, J.-S. A.; Wooley, K. L. “Structure-activity relationships of cationic shell-crosslinked knedel-like nanoparticles: Shell composition and transfection efficiency/cytotoxicity”, Biomaterials, 2010, 31, 1805-1813 Ma, J.; Bartels, J. W.; Li, Z.; Zhang, K.; Cheng, C.; Wooley, K. L. “Synthesis and solution-state assembly or bulk state thiol-ene crosslinking of pyrrolidinone- and alkene-functionalized amphiphilic block fluorocopolymers: from functional nanoparticles to anti-fouling coatings”, Aust. J. Chem., 2010, 63, 1159-1163 Li, Z.; Ma, J.; Cheng, C.; Zhang, K.; Wooley, K. L. “Synthesis of hetero-grafted amphiphilic diblock molecular brushes and their self-assembly in aqueous medium”, Macromolecules, 2010, 43, 1182-1184 Li, Y.; Hindi, K.; Watts, K. M.; Taylor, J. B.; Zhang, K.; Li, Z.; Hunstad, D. A. Cannon, C. L.; Youngs, W. J.; Wooley, K. L. “Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics”, Chem. Commun., 2010, 46, 121-123 Zhang, K.; Fang, H.; Li, Z.; Ma, J.; Hohlbauch, S. V.; Taylor, J.-S. A.; Wooley, K. L. “Composite soft-matter nanoscale objects: nanocylinder-templated assembly of nanospheres”, Soft Matter, 2009, 5, 3585-3589 (Cover article)

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