Gambhir, Sanjiv Sam - Stanford University - Department of Bioengineering

个人简介

Ph.D., UCLA Medical Scientist Training Program, Biomathematics (1990) M.D., UCLA, Medical Scientist Training Program (1993) B.S., Arizona State University, Physics (1983) Administrative Appointments Head, Nuclear Medicine Division (2003 - 2011) Division Chief, Molecular Imaging Program at Stanford (MIPS) (2003 - Present) Professor, Department of Radiology and Bio-X Program (2003 - Present) Member, Bio-X Program (2004 - Present) Professor (By courtesy), Bioengineering (2005 - Present) Residency Program Director, Nuclear Medicine Division (2008 - 2011) Division Chief, Canary Center for Cancer Early Detection at Stanford (2009 - Present) Professor (By courtesy), Materials Science & Engineering (2010 - Present) Member, Stanford Leadership Academy (2011 - 2012) Chair, Department of Radiology - Stanford University School of Medicine (2011 - Present) Director, Precision Health & Integrated Diagnostics (PHIND) (2016 - Present)

研究领域

My laboratory is developing imaging assays to monitor fundamental cellular/molecular events in living subjects including patients. Technologies such as positron emission tomography (PET), optical (fluorescence, bioluminescence, Raman), ultrasound, and photoacoustic imaging are all under active investigation. Imaging agents for multiple modalities including small molecules, engineered proteins, and nanoparticles are under development and being clinically translated. Our goals are to detect cancer early and to better manage cancer through the use of both in vitro diagnostics and molecular imaging. Strategies are being tested in small animal models and are also clinically translated. In the early detection setting we are exploring multiple strategies that are pushing the limits of the fewest numbers of detectable cancer cells. The goal is to intercept cancer early so that patient outcomes can be markedly improved. For the management of cancer we are focused on using imaging to optimize stratification of cancer patients, predicting response to therapy, and monitoring response to therapy and recurrence. We are particularly interested in cell based therapies and immunotherapies where molecular imaging can help optimize these therapies.

近期论文

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Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI. Scientific reports Liu, Y., Hanley, T., Chen, H., Long, S. R., Gambhir, S. S., Cheng, Z., Wu, J. C., Fakhri, G. E., Anvari, B., Zaman, R. T.2020; 10 (1): 5983 ICOS is an indicator of T cell-mediated response to cancer immunotherapy. Cancer research Xiao, Z., Mayer, A. T., Nobashi, T. W., Gambhir, S. S. SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo. ACS applied materials & interfaces Sukumar, U. K., Rajendran, J. C., Gambhir, S. S., Massoud, T. F., Paulmurugan, R. Radiotheranostics: a roadmap for future development LANCET ONCOLOGY Herrmann, K., Schwaiger, M., Lewis, J. S., Solomon, S. B., McNeil, B. J., Baumann, M., Gambhir, S. S., Hricak, H., Weissleder, R.2020; 21 (3): E146–E156 Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [F-18]DASA-23 MOLECULAR IMAGING AND BIOLOGY Beinat, C., Patel, C. B., Xie, Y., Gambhir, S. S.2020; 22 (1): 124–33 Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties. Nature biomedical engineering Song, G., Kenney, M., Chen, Y. S., Zheng, X., Deng, Y., Chen, Z., Wang, S. X., Gambhir, S. S., Dai, H., Rao, J. A mountable toilet system for personalized health monitoring via the analysis of excreta. Nature biomedical engineering Park, S. M., Won, D. D., Lee, B. J., Escobedo, D., Esteva, A., Aalipour, A., Ge, T. J., Kim, J. H., Suh, S., Choi, E. H., Lozano, A. X., Yao, C., Bodapati, S., Achterberg, F. B., Kim, J., Park, H., Choi, Y., Kim, W. J., Yu, J. H., Bhatt, A. M., Lee, J. K., Spitler, R., Wang, S. X., Gambhir, S. S. Radiotheranostics: a roadmap for future development. The Lancet. Oncology Herrmann, K., Schwaiger, M., Lewis, J. S., Solomon, S. B., McNeil, B. J., Baumann, M., Gambhir, S. S., Hricak, H., Weissleder, R.2020; 21 (3): e146–e156 Human biodistribution and radiation dosimetry of [18F]DASA-23, a PET probe targeting pyruvate kinase M2. European journal of nuclear medicine and molecular imaging Beinat, C., Patel, C. B., Haywood, T., Shen, B., Naya, L., Gandhi, H., Holley, D., Khalighi, M., Iagaru, A., Davidzon, G., Gambhir, S. S. Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1. Proceedings of the National Academy of Sciences of the United States of America Hsu, E. C., Rice, M. A., Bermudez, A., Marques, F. J., Aslan, M., Liu, S., Ghoochani, A., Zhang, C. A., Chen, Y. S., Zlitni, A., Kumar, S., Nolley, R., Habte, F., Shen, M., Koul, K., Peehl, D. M., Zoubeidi, A., Gambhir, S. S., Kunder, C. A., Pitteri, S. J., Brooks, J. D., Stoyanova, T. Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis ADVANCED FUNCTIONAL MATERIALS Rogalla, S., Flisikowski, K., Gorpas, D., Mayer, A. T., Flisikowska, T., Mandella, M. J., Ma, X., Casey, K. M., Felt, S. A., Saur, D., Ntziachristos, V., Schnieke, A., Contag, C. H., Gambhir, S. S., Harmsen, S. 2019; 29 (51) EVALUATION OF [18F]DASA-23 FOR NON-INVASIVE MEASUREMENT OF ABERRANTLY EXPRESSED PYRUVATE KINASE M2 IN GLIOMA: FIRST-IN-HUMAN STUDY Patel, C., Beinat, C., Haywood, T., Murty, S., Xie, Y., Recht, L., Nagpal, S., Thomas, R., Khalighi, M., Gandhi, H., Holley, D., Gambhir, S.OXFORD UNIV PRESS INC. 2019: 169 TUMOR TREATING FIELDS LEADS TO CHANGES IN MEMBRANE PERMEABILITY AND INCREASED PENETRATION BY ANTI-GLIOMA DRUGS Chang, E., Patel, C., Beinat, C., Young, C., Flores, T., Zeng, Y., Joubert, L., Arami, H., Natarajan, A., Sinclair, R., Gambhir, S.OXFORD UNIV PRESS INC. 2019: 93 Engineering of a novel subnanomolar affinity fibronectin III domain binder targeting human programmed death-ligand 1. Protein engineering, design & selection : PEDS Ramakrishnan, S., Natarajan, A., Chan, C. T., Panesar, P. S., Gambhir, S. S. How to Prevent a Leaky Pipeline in Academic Radiology: Insights From a Faculty Survey JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY Daldrup-Link, H., Villavasso, K., Zhao, Q., Lu, Y., Ranieri, A., Simard, C., Gambhir, S. 2019; 16 (9): 1220–24 In Vivo Translation of the CIRPI System: Revealing Molecular Pathology of Rabbit Aortic Atherosclerotic Plaques JOURNAL OF NUCLEAR MEDICINE Zaman, R. T., Yousefi, S., Chibana, H., Ikeno, F., Long, S. R., Gambhir, S. S., Chin, F. T., McConnell, M. V., Xing, L., Yeung, A. 2019; 60 (9): 1308–16 Simultaneous transrectal ultrasound and photoacoustic human prostate imaging. Science translational medicine Kothapalli, S., Sonn, G. A., Choe, J. W., Nikoozadeh, A., Bhuyan, A., Park, K. K., Cristman, P., Fan, R., Moini, A., Lee, B. C., Wu, J., Carver, T. E., Trivedi, D., Shiiba, L., Steinberg, I., Huland, D. M., Rasmussen, M. F., Liao, J. C., Brooks, J. D., Khuri-Yakub, P. T., Gambhir, S. S.2019; 11 (507) Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy. Molecular cancer therapeutics Kanada, M., Kim, B. D., Hardy, J. W., Bachmann, M. H., Bernard, M. P., Perez, G. I., Zarea, A. A., Ge, T. J., Withrow, A., Ibrahim, S. A., Toomajian, V., Gambhir, S. S., Paulmurugan, R., Contag, C. H., Ronald, J. A.