Wang, Szu-Wen - University of California, Irvine - Department of Chemical Engineering and Materials Science

个人简介

Ph.D., Stanford University, Chemical Engineering, 1999 M.S., Stanford University, Chemical Engineering, 1994 B.S., University of Illinois at Urbana-Champaign, Chemical Engineering, 1993

研究领域

One of the current challenges in biomaterials research is the design and fabrication of functional nanostructures at progressively smaller length scales. Since biology has been enormously successful in assembling complex nanoscale systems, research in Dr. Wang's group couples the principles of self-assembly with nature-inspired macromolecular systems to engineer new materials and therapeutic strategies. The approach in Dr. Wang's research uses the detailed control that genetic engineering provides in defining the polymeric architecture of proteins, and unites this with synthetic strategies that broaden the scope of chemical functionality. This enables a better understanding of the relationship between molecular organization and material characteristics, which can then be used towards designing new material properties. The research group is currently investigating (1) the fabrication of inorganic nanoarrays using biological templates, (2) the design of nanoscale protein complexes for molecular transport of molecules, and (3) the development of novel biopolymers for drug delivery. These studies have relevance in technological areas that include pharmaceutics, tissue engineering, biosensors, and electronic and optical devices.

近期论文

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B. Chou, P. Mirau. T. Jiang., S.-W. Wang, K.J. Shea. "Hydrogel Affinity Reagents for Molecules with Lipid-Like Domains." Biomacromolecules, 2016. DOI: 10.1021/acs.biomac.6b00296. N.M. Molino, M. Neek, J.A. Tucker, E.L. Nelson, S.-W. Wang. "Viral-Mimicking Protein Nanoparticle Vaccine for Eliciting Anti-tumor Responses." Biomaterials. 86:83-91 (2016). Q. Chen, Q. Sun, N.M. Molino, S.-W. Wang, E.T. Boder, W. Chen. "Sortase-A mediated Multi-functionalization of Protein Nanoparticles." Chemical Communications. 51:12107-12110 (2015). R. Que, S.W.P. Chan, A. Jabaiah, R.H. Lathrop, N.A. Da Silva, and S.-W. Wang. "Tuning Cellular Response by Modular Design of Bioactive Domains in Collagen." Biomaterials. 53:309-317 (2015). R. Que, A. Mohraz, N. Da Silva, S.-W. Wang. "Expanding Functionality of Recombinant Human Collagen Through Engineered Non-Native Cysteines." Biomacromolecules. 15:3540-3549 (2014). DOI 10.1021/bm500735d. Y.K. Kim, R. Que, S.-W. Wang, W. Liu. "Modification of Biomaterials with a Self Protein Inhibits the Macrophage Response." Advanced Healthcare Materials. 3(7):989-994 (2014). N.M. Molino, S.-W. Wang. "Caged Protein Nanoparticles for Drug Delivery." Current Opinion in Biotechnology. 28:75-82 (2014). Invited contribution for thematic issue on "Nanobiotechnology." A. Jabaiah, X. Wang, S. K. Raman, R. Ragan, N.A. Da Silva, S.-W. Wang. "Nanoscale Architecture and Cellular Adhesion of Biomimetic Collagen Substrates." Journal of Biomaterials Applications. 28(9):1354-1365 (2014). D. Ren, F. Kratz, S.-W. Wang. "Engineered drug-protein nanoparticle complexes for folate receptor targeting." Biochemical Engineering Journal. 89:33-41 (2014). Invited contribution for special issue on "Bionanofabrication." N.M. Molino, A.K.L. Anderson, E.L. Nelson, S.-W. Wang. "Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation” ACS Nano. 7:9743-9752 (2013). S.W.P. Chan, J. Greaves, N. Da Silva, S.-W. Wang. “Assaying Proline Hydroxylation in Recombinant Collagen Variants by Liquid Chromatography-Mass Spectrometry,” BMC Biotechnology. 12:51 (2012). DOI: 10.1186/1472-6750-12-51