个人简介

1993 Ph.D. The Ohio State University 1987 B.S. Rennselaer Polytechnic Institute

研究领域

Organic,Carbohydrate, Bioorganic & Medicinal Chemistry

My research group has been working in two related areas of organic synthesis: carbohydrate synthesis and natural product synthesis. The unifying theme that connects our research in these two areas is our method of synthesis (asymmetric catalysis) and target selection (anti-cancer, anti-viral and anti-microbial agents). A recurring theme in the group’s synthetic approaches to both types of targets is our reliance on asymmetric catalysis for the control of asymmetry. Fundamental to our approach is the development of highly efficient routes that transform, via catalysis, inexpensive achiral starting materials into enantiopure products, which are poised for the conversion into complex molecules with biologically relevant properties (i.e., enantioselective synthesis of a new “chiral pool” via asymmetric catalysis). Recently, we have found that these approaches have matured to the point where we have developed enantioselective routes to these complex molecules in sufficient quantities that are amenable for biomedical investigations with the ultimate goal of developing new therapeutics for the treatment of cancer and related infections diseases.

近期论文

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Silylated organometals: a family of recyclable homogeneous catalysts JL Huang, JZ Wang, HX Li, H Guo, GA O'Doherty Green Chemistry Synthesis and Structure-Activity-Relationship Study of 5a-Carbasugar Analogues of SL0101 M Li, Y Li, RM Mrozowski, ZM Sandusky, M Shan, X Song, B Wu, Q Zhang, ... ACS medicinal chemistry letters De Novo Synthesis and Biological Evaluation of C6 ″-Substituted C4 ″-Amide Analogues of SL0101 RM Mrozowski, ZM Sandusky, R Vemula, B Wu, Q Zhang, DA Lannigan, ... Organic letters 16 (22), 5996-5999 The Alkyne Zipper Reaction in Asymmetric Synthesis K Avocetien, Y Li, GA O'Doherty Modern Alkyne Chemistry, 365-394 Structural analysis of cardiac glycosides to determine the basis for tumoristatic activity V Kaushik, Y Kaulkarni, C Wright, G O'Doherty, N Azad, A Iyer Cancer Research 74 (19 Supplement), 3205-3205 MonoD, a novel analogue of digitoxin, induces superoxide mediated autophagic cell death in H460 lung cancer cells Y Kulkarni, V Kaushik, C Wright, G O'Doherty, N Azad, A Iyer Cancer Research 74 (19 Supplement), 1331-1331 Total Synthesis of Tetrahydrolipstatin and Stereoisomers via a Highly Regio-and Diastereoselective Carbonylation of Epoxyhomoallylic Alcohols M Mulzer, BJ Tiegs, Y Wang, GW Coates, GA O’Doherty Journal of the American Chemical Society 136 (30), 10814-10820 Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation V Pongrakhananon, TA Stueckle, HYL Wang, GA O’Doherty, CZ Dinu, ... Biochemical pharmacology 88 (1), 23-35 Cryptocaryol Structure–Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4 MF Cuccarese, Y Wang, PJ Beuning, GA O’Doherty ACS medicinal chemistry letters 5 (5), 522-526 Digitoxin Analogues with Improved Anticytomegalovirus Activity H Cai, HYL Wang, R Venkatadri, DX Fu, M Forman, SO Bajaj, H Li, ... ACS medicinal chemistry letters 5 (4), 395-399 Enantioselective Synthesis of α− and β− Boc-‐protected 6-‐Hydroxy-‐pyranones: Carbohydrate Building Blocks SO Bajaj, JR Farnsworth, GA O’Doherty Org. Synth 91, 338-355 Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity SO Bajaj, P Shi, PJ Beuning, GA O'Doherty MedChemComm 5 (8), 1138-1142 De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation SO Bajaj, EU Sharif, NG Akhmedov, GA O'Doherty Chemical Science 5 (6), 2230-2234 REGIOSELECTIVE BROMINATION: AN APPROACH TO THE D-RING OF THE GILVOCARCINS EU Sharif, GAO DohertyU Heterocycles 88 (2), 1275-1285 Merremoside D: De Novo Synthesis of the Purported Structure, NMR Analysis, and Comparison of Spectral Data EU Sharif, HYL Wang, NG Akhmedov, GA O’Doherty Organic letters 16 (2), 492-495 De novo approaches to monosaccharides and complex glycans MF Cuccarese, JJ Li, GA O’Doherty Modern Synthetic Methods in Carbohydrate Chemistry: From Monosaccharides to ... Hydrogen-Bond Networks: Strengths of Different Types of Hydrogen Bonds and An Alternative to the Low Barrier Hydrogen-Bond Proposal A Shokri, Y Wang, GA O’Doherty, XB Wang, SR Kass Journal of the American Chemical Society 135 (47), 17919-17924 A novel use of gentamicin in the ROS-mediated sensitization of NCI-H460 lung cancer cells to various anticancer agents MF Cuccarese, A Singh, M Amiji, GA O’Doherty ACS chemical biology 8 (12), 2771-2777 Carbohydrates—Tools for Stereoselective Synthesis. Edited by Mike Martin Kwabena Boysen. GA O'Doherty Angewandte Chemie International Edition 52 (39), 10156-10156 Carbohydrates–Tools for Stereoselective Synthesis. Herausgegeben von Mike Martin Kwabena Boysen. GA O'Doherty Angewandte Chemie 125 (39), 10342-10342