Piomelli, Daniele - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions Jun 1988 National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award Jun 1990 National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award May 1999 National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award May 2001 ad hoc member; NIH Centers Review Committee May 2001 ad hoc member; NIH Program Projects Review Committee Jun 2001 ad hoc member; NIAAA Board of Counselors Jun 2001 Course Director; International School of Immunology, “Ruggero Ceppellini” Sep 2001 NIH Independent Investigator Award May 2002 Grass Traveling Fellowship Jul 2002 Chancellor Scholar; University of California, Irvine Jul 2002 International Kemali Foundation Prize in Neurosciences Oct 2003 Member of the NIDA Delegation to the Office of Drug Control Policy (ONDCP) May 2005 National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Award May 2007 Member of the National Advisory Council on Drug Abuse Apr 2008 Chair, NIDA Scientific Director Review, Baltimore, MD May 2009 National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Award Sep 2010 National Institute on Drug Abuse (NIDA) Avant-Garde Award for Innovative Medication Development Research

研究领域

Dr. Piomelli was trained in neuroscience and pharmacology. Research in his lab is focused on the function of lipid-derived messengers, with particular emphasis on the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. Current research efforts converge on three areas: formation and deactivation of anandamide and 2-arachidonylglycerol; physiological roles of the endogenous cannabinoid system; development of therapeutic agents that target anandamide and 2-arachidonylglycerol metabolism. Primary neural cell cultures and state-of-the-art analytical techniques such as liquid chromatography/mass-spectrometry are used to investigate formation and deactivation of anandamide and 2-arachidonoylglycerol in brain cells. Protein purification and cloning approaches are employed to characterize the molecular mechanisms underlying these processes. Cellular pharmacology and medicinal chemistry, in collaboration with leading international labs, are used to identify pharmacological agents that interfere with various aspects of endogenous cannabinoid function, and their therapeutic potential is explored in vitro and in vivo.

近期论文

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N. Stella, P. Schweitzer and D. Piomelli, 1997. A second endogenous cannabinoid that modulates long-term potentiation. Nature 388, 773-778. M. Beltramo, N. Stella, A. Calignano, S.Y. Lin, A. Makryiannis and D. Piomelli, 1997. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277, 1094-1097. A. Calignano, G. La Rana, A. Giuffrida and D. Piomelli, 1998. Control of pain initiation by endogenous cannabinoids. Nature 394, 277-281. A. Giuffrida, L. Parsons, T.M. Kerr, F. Rodríguez de Fonseca, M. Navarro and D. Piomelli, 1999. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nat Neurosci 2, 358-363. D. Piomelli, M. Beltramo, S. Glasnapp, S.Y. Lin, A. Goutopoulos, Xiang-Qun Xie and A. Makriyannis, 1999. Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci U S A 96, 5802-5807. I. Katona, F. Désarnaud, A. Giuffrida, G. La Rana, K. Mackie, T.F. Freund and D. Piomelli, 2000. Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature 408, 96-101. F. Rodríguez de Fonseca, M. Navarro, R. Gómez, L. Escuredo, F. Nava, J. Fu, E. Murillo-Rodríguez, A. Giuffrida, J. LoVerme, S. Gaetani, S. Kathuria, C. Gall and D. Piomelli, 2001. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212. T. Dinh, D. Carpenter, F.M. Leslie, T.F. Freund, I. Katona, S.L. Sensi, S. Kathuria and D. Piomelli, 2002. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci U S A 99, 10819-10824. S. Kathuria, S. Gaetani, D. Fegley, F. Valiño, A. Duranti, A. Tontini, M. Mor, G. Tarzia, G. La Rana, A. Calignano, A. Giustino, M. Tattoli, M. Palmery, V. Cuomo and D. Piomelli, 2003. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9, 76-81. T.F. Freund, I. Katona and D. Piomelli, 2003. The role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83, 1017-1066. J. Fu, S. Gaetani, F. Oveisi, J. LoVerme, A. Serrano, F. Rodríguez de Fonseca, A. Rosengarth, H. Luecke, B. Di Giacomo, G. Tarzia and D. Piomelli, 2003. Oleylethanolamide regulates feeding and body weight through activation of PPAR-?. Nature 425, 90-93.