Grando, Sergei A. - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions 2016 Best of Irvine Award; 2016 Featured in Orange Coast Magazine among Top Doctors chosen by their peers; 2015 Recognized among Castle Connolly Top Doctor for Irvine, CA; 2013-present Vice Chair for Research, Department of Dermatology, UC Irvine; since 2013 Included in Best Doctors in America database; since 2012 HealthGrades Recognized Doctor; 2010 Doctor of the Year, International Pemphigus and Pemphigoid Foundation, USA 2010-present Vice Chair, Medical Advisory Board of International Pemphigus and Pemphigoid Foundation; 2003-2007 Vice Chair, Dermatology Foundation of California; 2002-present Honorary Member, Ukrainian Association of Dermatologists, Venereologists, Cosmetologists, Ukraine; 2001 2001 Clinical Innovator Award, Flight Attendant Medical Research Institute, USA; 1995 FIRST Award, NIH, NIAMS, USA; 1991-present Honorary Member, Belgian Royal Society of Dermatology and Venereology, Belgium; 1981, 1982, 1983, 1984, 1985, 1986, 1987, 1988 Annual Award for the Best Scientific Presentation among Young Investigators, PostGraduate Institute for Physicians, Kiev, Ukraine; 1987 Award, Municipal Society for Scientists and Specialists, Kiev, Ukraine; 1988 Premium, Ukrainian Republican Society for Inventors, Kiev, Ukraine. Appointments 1996-2007 Professor of Dermatology, Department of Dermatology, University of California-Davis 1992-1996 Associate Professor of Dermatology, Department of Dermatology, University of Minnesota, 1991-1992 Visiting Professor, Department of Dermatology, University of Minnesota 1989-1990 Acting Professor, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kiev, Ukraine 1985-1989 Assistant Professor, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kiev, Ukraine 1984-1985 Instructor of Dermatology and Venereology, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kiev, Ukraine

研究领域

IMMUNOPATHOPHYSIOLOGY AND DEVELOPMENT OF NON-STEROIDAL TREATMENT OF PEMPHIGUS Dr. Grando utilized pemphigus patients' IgGs as a probe to identify the pathophysiologically relevant target antigens in the autoimmune blistering disease pemphigus. He found, unexpectedly, that autoantibodies targeted several known as well as novel members of the acetylcholine (ACh) receptor gene superfamilies expressed by skin cells. Later, he has now demonstrated that these receptors control cell shape and intercellular adhesion, and their blockade by auto-antibodies produces cell dysadhesion and blisters. Dr. Grando's lab demonstrated that pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocyte adhesion molecules. He discovered novel mechanisms of targeting cell death and survival and therapeutic action of intravenous IgG (IVIg) in pemphigus. The results indicate that in different pemphigus patients, IgG-induced acantholysis proceeds predominantly via distinct, yet complementary, pathways of programmed cell death and that IVIg protect target cells by up-regulating endogenous caspase and calpain inhibitors. Grando's work in autoimmune pemphigus and paraneoplastic pemphigus has led to the development of non-steroidal therapy for pemphigus and other diseases associated with blistering. He has conducted an IRB-approved clinical trial using a well-tolerated acetylcholinesterase inhibitor, Mestinon, in the treatment of pemphigus patients. The results of his work have altered the way physicians throughout the world understand the mechanisms of pemphigus, and have led directly to the development of new treatment of pemphigus with cholinergic agonist, such as topical application of pilocarpine.

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Grando SA, Bezdenezhnykh SE, Golota OV: Frequency of chronic non-specific lung diseases among populations of industrial cities. In: Problems in Hygiene and Environment, (Moscow), 1979, p. 66. (In Russian). Grando SA: Gall bladder nerves under condition of experimental gastric rejection. In: Proceedings of the All-Union Scientific Conference on Digestion Physiology and Pathology, (Odessa), 1979, p. 12. (In Russian). Glukhenky BT, Grando SA, Glukhenkaya AB: Preliminary results of the combined treatment of patients with atopic dermatitis. In: Proceedings of the Annual Scientific & Practical Conference of Kharkhov Regional Dermato-Venereologic Hospital, (Kharkhov), 1984, p. 14. (In Russian). Glukhenky BT, Boiko YY, Bratys FF, Grando SA: Prostatites as a complication of gonococcal infection. In: Problems in sexopathology and the sexual harmony, (Voroshilovgrad), 1988, pp. 102-103. (In Russian). Kurchenko AI, Grando SA: Thymogen immunocorrection in treatment of patients with eczema. In: Current Problems of Scientific and Practical Dermato-Venereology, (Dnepropetrovsk), 1990, pp. 82-83. (In Russian). Grando SA: The use of proteinase inhibitors in atopic dermatitis. In: Proceedings of the YIII All-Union Congress on Dermato-Venereology, (Moscow), 1985, Vol. 1, p. 62. (In Russian). Glukhenky BT, Lastovetskaya GI, Kalyuzhnaya LD, Kutsenko NS, Kozij LM, Boiko YY, Grando SA, Choban VI: The results of the study of immune system and liver function in patients with secondary syphilis. Clinical and laboratory follow up study. In: Proceedings of the YIII All-Union Congress on Dermato-Venereology, (Moscow), 1985, Vol. 2, p. 351. (In Russian). Grando SA, Makarov AV, Kostromin AP, Demidov SV: Pathogenetic grounds for immunosuppressive therapy of patients with autoimmune bullous dermatoses. In: Proceedings of the Y Ukrainian Congress on Dermato-Venereology, (Kharkhov), 1986, p. 95. (In Russian). Demidov SV, Kostromin AP, Khrapunov SN, Borovok MI, Kujbeda BB, Grando SA: The effect of thymus-derived preparations on the proliferation, cytotoxicity and activity of cyclic nucleotide anabolism and catabolism enzymes in spleen lymphocytes under condition of BCG vaccination. In: Proceedings of the International Workshop on Mathematical Modeling in Immunology and Medicine, (Kiev), 1988, p. 27. (In Russian). Glukhenky BT, Grando SA, Kostromin AP, Demidov SV, Chernyavsky AI, Makarov AV, Korostash TA: Cytotoxicity of peripheral blood mononuclear cells from elderly people against autologous epidermal keratinocytes. In: Proceedings of the Y All-Union Congress on Gerontology and Geriatrics, 13 (Kiev), 1988, Vol. 1, p. 154. (In Russian).