Fruehauf, John - University of California, Irvine - Department of Biological Chemistry

研究领域

My group has focused on mechanisms of drug action and resistance with the goal of developing predictive tests that improve therapeutic outcomes for cancer patients. Active areas in my laboratory at UC Irvine include the role of glutathione and redox mechanisms in drug resistance, development of vascular endothelial cell models to predict response to antiangiogenesis agents, and the examination of differential gene expression that can distinguish between drug resistant and drug sensitive tumors. Recently we have focused on translating our bench work to the bedside through the development of clinical trials that include correlative laboratory studies.

近期论文

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Parker R. Mehta R, Filka E, Fruehauf JP, Cloughesy T. A prospective blinded study of the predictive value of extreme drug resistance assays in patients receiving CPT-11 for recurrent glioma. J Neuro-Oncology, 66:365-375, 2004. Fruehauf JP, Kong KM, Jakowatz JG. Docetaxel and vinorelbine plus GM-CSF in malignant melanoma. Oncology 19 (suppl 2):19-22, 2005. Goodhart M, Fruehauf JP, Buller R. The Relationship Of Molecular Markers Of P53 Function And Angiogenesis To Prognosis Of Stage I Epithelial Ovarian Cancer. Clin Cancer Res 11:3733-3742, 2005. Tewari K, Mehta RS, Burger RA, Yu I-R, Kyshtoobayeva AS, Monk BJ, Manetta A, Berman ML, DiSaia PJ, Fruehauf JP. Conservation of in vitro drug resistance profiles in epithelial ovarian cancer. Gynecol Oncol 98:360-368, 2005. Tewari D, Monk BJ, Parker R, Heck JD, Burger RA, Fruehauf JP. Gene expression profiling of in vitro radiation resistance in cervical carcinoma: a feasibility study. Gynecol Oncol 99(1):84-91, 2005. Fruehauf JP, Brem H, Brem S, Sloan A, Barger G, Parker R. In Vitro Drug Response and Molecular Markers Associated with Drug Resistance in Malignant Gliomas. Clin Can Res 12:4523-32, 2006 Prabhu S, Saadat D, Zhang M, Halbur L, Fruehauf JP, Ong ST. A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. Oncogene 26:1188-200, 2007. Nishimoto KP, Newkirk D, Hou S, Fruehauf J, Nelson EL. Fluorescence activated cell sorting (FACS) using RNAlater to minimize RNA degradation and perturbation of mRNA expression from cells involved in initial host microbe interactions. J Microbiol Methods. 70(1):205-8, 2007. Einspahr JG, Thomas TL, Saboda K, Nickolof BJ, Wameke J, Curiel-Lewandrowski C, Ranger-Moore J, Duckett L, Bangert J, Fruehauf JP, Alberts DS. Expression of VEGF in early cutaneous melanocytic lesion progression. Cancer: Oct 11, 2007 epub Mathews MS, Linskey ME, Hasso A, Fruehauf JP. The effect of bevacizumab (Avastin) on neuroimaging of brain metastases. Surgical Neurology 2007. In press Su M-Y, Yu H, Chiou J-Y, Wang J, Fruehauf JP, Nalcioglu O, Mehta RS, Baick CH. Measurements of Volumetric Changes and Vascular Changes with Dynamic Contrast Enhanced MRI for Cancer Therapy Monitoring. Technology in Cancer Research and Treatment, 1(6): 479-488, 2002