Yokomori, Kyoko - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions Honors: 1990-1991 Fieger Pre-doctoral Fellowship 1993-1996 Leukemia Society of America Fellow 1996-1999 Leukemia Society of America Special Fellow 1999-2001 March of Dimes Basil O’Connor Starter Scholar Research Award 2000-2005 Leukemia & Lymphoma Society Scholar Appointments 1991 – 1992 Postdoctoral Fellow, Dr. Michael Lai's laboratory, Howard Hughes Medical Institute, University of Southern California, Department of Microbiology 1992 – 1997 Postdoctoral Fellow, Dr. Robert Tjian's laboratory, Howard Hughes Medical Institute, University of California, Berkeley

研究领域

Chromosomes are essential components of the cell, storing genetic information necessary to carry out the normal life cycle of the cell. They serve as templates for replication and transcription, and undergo mitosis to maintain genetic information over generations. To achieve these multiple roles, chromosomes exhibit dynamic structural changes in a cell cycle-dependent manner. Although genetic studies identified various important cell cycle regulators such as cyclin and cdks, the actual molecular machine that drives structural changes of chromosomes in response to these cell cycle regulators remains elusive. In recent years, the SMC (structural maintenance of chromosomes) family proteins were found to play important roles in several fundamental chromosome functions including chromosome condensation, segregation, recombination, repair and X chromosome dosage compensation. The SMC proteins are physically associated with chromosomes, suggesting that they may be part of the machinery that regulates local and global structural changes of chromosomes required for these functions. The research objective of our laboratory is to biochemically identify and characterize the SMC-containing multiprotein complexes in human cells that modulate higher order chromatin structure, and study how their function is regulated during cell cycle using biochemical, cell biological and genetic approaches.

近期论文

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Yokomori, K., Okada, N., Murai, Y., Goto, N., and Fujiwara, K. (1989). Enterohepatitis in Mongolian gerbils (Meriones unguiculatus) inoculated perorally with Tyzzer's organism (Bacillus piliformis). Laboratory Animal Science 39: 16-20. Yokomori, K., La Monica, N., Makino, S., Shieh, C.-K., and Lai, M.M.C. (1989). Biosynthesis, structure and biological activities of envelope protein gp65 of murine coronavirus. Virology 173 : 683-691. Yokomori, K., Baker, S.C., Stohlman, S.A., and Lai, M.M.C. (1992). Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus. J. Virol. 66 : 2865-2874. Yokomori, K., Banner, L.R., and Lai, M.M.C. (1992). Coronavirus mRNA transcription: UV light transcriptional mapping studies suggest an early requirement for a genomic-length template. J. Virol. 66: 4671-4678. Yokomori, K. and Lai, M. M. C. (1992). Mouse hepatitis virus utilizes two carcinoembryonic antigens as alternative receptors. J. Virol. 66: 6194-6199. Yokomori, K. and Lai, M. M. C. (1992). The receptor for mouse hepatitis virus in the resistant mouse strain SJL is functional: implications for the requirement of a second factor for viral infection. J. Virol. 66: 6931-6938. Chen, D.S., Asanaka, M., Yokomori, K., Wang, F.-I., Hwang, S. B., Li, H.-P., and Lai, M.M.C. (1995). A novel pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Proc. Natl. Acad. Sci. USA 92: 12095-12099. Yokomori, K., Admon, A., Goodrich, J.A., Chen, J.-L., and Tjian, R. (1993). Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex. Genes & Dev. 7: 2235-2245. Yokomori, K., Chen, J.-L., Admon, A., Zhou, S., and Tjian R. (1993). Molecular cloning and characterization of dTAFII30a and dTAFII30ß: two small subunits of Drosophila TFIID. Genes & Dev. 7: 2587-2597. Verrijzer, C.P., Yokomori, K., Chen, J.-L., and Tjian, R. (1994). Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. Science 264: 933-941. Yokomori, K., Zeidler, M. P., Chen, J.-L., Verrijzer, C. P., Mlodzik, M., and Tjian, R. (1994). Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes & Dev. 8: 2313-2323. http://genesdev.cshlp.org/content/8/19/2313.long Chen, J.-L., Attardi, L. D., Verrijzer, C. P., Yokomori, K., and Tjian, R. (1994). Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell 79: 93-105. Verrijzer, C. P., Chen, J.-L., Yokomori, K., and Tjian, R. (1995). Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II. Cell 81: 1115-1125.