Steele, Rob - University of California, Irvine - Department of Biological Chemistry

个人简介

Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA, 1980-1986

研究领域

My laboratory has been using Hydra as a model system to investigate questions in developmental and evolutionary biology since I joined the UC Irvine faculty in 1986. In 1989, my lab published the first paper describing the cloning of a Hydra protein-coding gene. I was the corresponding author on the Hydra genome paper that was published in Nature in 2010. Hydra is well known for its regenerative powers, its robust patterning system, and its lack of senescence. We are using a variety of approaches to manipulate genes in Hydra in an attempt to understand the molecular foundations of the remarkable biology of this seemingly simple animal. Hydra is a member of the animal phylum Cnidaria, which is the sister group to Bilateria, the animal group that includes humans; thus our studies with Hydra will inform us about human biology.

近期论文

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Carter, J. A., Hyland, C., Steele, R. E., Collins, E.-M. S. (2016). Dynamics of mouth opening in Hydra. Biophysical Journal, 110(5), 1191-1201. Juliano, C. E., Lin, H., Steele, R. E. (2014). Generation of transgenic Hydra by embryo microinjection. Journal of Visualized Experiments, 91, DOI: 10.3791/51888. Juliano, C. E., Reich, A., Liu, N., Uman, S., Reenan, R. A., Wessel, G., Steele, R. E., Lin, H. (2014). Analysis of the PIWI-piRNA pathway in Hydra reveals broad function in somatic adult stem cells. Proceedings of the National Academy of Sciences, U.S.A., 111(1), 337-342. Fidler, A. L., Vanacore, R. M., Chetyrkin, S., Pedchenko, V. K., Bhave, G., Yin, V. P., Stothers, C. L., Rose, K. L., McDonald, W. H., Clark, T., Borza, D.-B., Steele, R. E., Aspirnauts, T., Hudson, J. K., Hudson, B. G. (2014). A unique covalent bond in basement membranes is a primordial innovation for tissue evolution. Proceedings of the National Academy of Sciences U.S.A., 111(1), 331-336. Glauber, K. M., Dana, C. E., Park, S. S., Colby, D. A., Noro, Y., Fujisawa, T., Chamberlin, A. R., Steele, R. E. (2013). A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. Development, 140(23), 4788-4796. Dana, C. E., Glauber, K. M., Chan, T. A., Bridge, D. M., Steele, R. E. (2012). Incorporation of a horizontally transferred gene into an operon during cnidarian evolution. PLoS One, 7(2), e31643. Steele, R. E. (2012). The Hydra Genome: Insights, Puzzles, and Opportunities. International Journal of Developmental Biology, 56, 535-542.