Sassone-Corsi, Paolo - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions 1977 - Philips European Award for Young Investigators 1990 - Member of the European Molecular Biology Organization 1994 - EMBO Gold Medal 1996 - Rosen Prize (Fondation de la Recherche Médicale), France 1997 - Grand Prix Liliane Bettencourt pour la Recherche, France 2001 - Segerfalk Award Lecture, Lund University, Sweden 2003 - Grand Prix Charles-Léopold Mayer de l’Académie des Sciences, Paris 2003 - ISI Highly Cited 2004 - Edwin B. Astwood Award Lecture of The Endocrine Society, USA 2004 - The Umesono Memorial Award Lecture, The Salk Institute, San Diego, USA. 2004 - CNRS Silver Medal, Paris 2010 - Athalie Clarke Achievement Award from the Research Associates, a community-based support group for the University of California, Irvine, School of Medicine 2010 - Appointed Donald Bren Professor, established to support outstanding faculty members and to enhance scholarship, research and creative achievement 2011 - Roy O. Greep Award Lecture for outstanding contributions to research in endocrinology April 2011 - The 2012 Transatlantic Medal, The Society of Endocrinology, for significant contributions to the discipline and to promote connections between endocrinology in the United Kingdom and North America. June 2011 - Selected as an external member of the Max Planck Society, one of the world's most prestigious scientific groups.

研究领域

Dr. Sassone-Corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. These events have important consequences for the understanding of cellular proliferation, oncogenesis and differentiation. The stimulation of intracellular pathways and the activation of specific protein kinases lead to transcriptional regulation by changes in the phosphorylation state of nuclear factors. These act as final targets of different pathways and modulate expression from specific regulatory sites. The strength of these studies is particularly evident within physiological settings which have been investigated by this lab, the molecular control of circadian rhythms and the differentiation of male germ cells.

近期论文

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Whitmore, D., Foulkes, N. S., Strähle, U. and Sassone-Corsi, P. (1998) Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neurosci. 1, 701-708 . Fimia, G. M., De Cesare, D. and Sassone-Corsi, P. (1999) CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 398, 165-169. Sassone-Corsi, P., Mizzen, C. A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S., Hanauer, A. and Allis, C. D. (1999) Requirement of Rsk-2 for Epidermal Growth Factor-activated phosphorylation of Histone H3. Science 285, 886-891. Whitmore, D., Foulkes, N. S. and Sassone-Corsi, P. (2000) Light acts directly on organ cells in culture to set the vertebrate circadian clock. Nature 404, 87-91 Cheung, P., Allis, C. D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone modifications. Cell 103, 263-271. Crosio, C., Cermakian, N., Allis, D. C. and Sassone-Corsi, P. (2000) Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neurosci. 3, 1241-1247 Sassone-Corsi, P. (2002) Unique chromatin remodeling and transcriptional regulation in spermatogenesis. Science 296, 2176-2178. Pando, M. P., Morse, D., Cermakian, N. and Sassone-Corsi, P. (2002) Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance. Cell 110, 107-117. Macho, B., Brancorsini, S., Fimia, G. M., Setou, M., Hirokawa, N. and Sassone-Corsi, P. (2002) CREM-Dependent Transcription in Male Germ Cells Controlled by a Kinesin. Science 298, 2388-2390. Yanagimachi, R., Wakayama, T., Kishikawa, H., Fimia, G. M., Monaco, L. and Sassone-Corsi, P. (2004) Production of fertile offspring from genetically infertile mice. Proc. Natl. Acad. Sci. USA 101, 1691-1695. Kimmins, S. and Sassone-Corsi, P. (2005) Chromatin remodeling and epigenetic features of germ cells. Nature 434, 583-589. Hirayama, J., Cardone, L., Doi, M. and Sassone-Corsi, P. (2005) Common Pathways in Circadian and Cell Cycle Clocks: Light-dependent Activation of Fos/AP-1 in Zebrafish Controls CRY-1a and WEE-1. Proc. Natl. Acad. Sci. USA 102, 10194-10199. Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J. and Sassone-Corsi, P. (2005) Circadian clock control by SUMOylation of BMAL1. Science 309, 1390-1394.