Sandmeyer, Suzanne - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions American Academy of Microbiology, Elected Fellow American Association for the Advancement of Science, Elected Fellow UCI College of Medicine Research Associates' Award Appointments Damon Runyon-Walter Winchell Postdoctoral Fellow

研究领域

Our laboratory studies retroviruslike elements using the budding yeast (Saccharomyces cerevisiae) retrotransposon Ty3. Retrotransposons make up almost half of the human genome but their regulation and impact on genomic function is not yet well understood; we study Ty3 as a model for understanding both retrotransposons and also retroviruses. Ty3 studies have elucidated the roles of virus structural protein in capsid assembly, roles of nucleoporins in nuclear entry and roles of transcription factors in integration specificity. We are currently focused on how RNA processing proteins help to localize and package the genomic RNA into particles. In addition, the laboratory is working to elucidate the genomic features which affect integration into chromosomal target sites. The laboratory uses a combination of molecular genetics, biochemistry and next generation sequencing to address these questions.

近期论文

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Patterson, K., Yu, J., Landberg, J., Chang, I., Shevarebi, F., Bilanchone, V., Tam, T., Sandmeyer, S. Functional genomics profiling of the industrial yeast Yarrowia lipolytica (submitted). Magnan*, C., Yu*, J. Chang*, I., Jahn, E., Kanomata, Y., Wu, J., Zeller, M., Oakes, M., Baldi, P., Sandmeyer, S. Sequence assembly of Yarrowia lipolytica strain W29/CLIB89 shows transposable element diversity. (2016) PLOS ONE, http://dx.doi.org/10.1371/journal.pone.0162363. Sandmeyer, S.B., Patterson, K., and Bilanchone, V.W., Ty3, a position-specific retrotransposon budding yeast. (2015) Chapter 42. Mobile DNA III, Ed. Craig, N. L., Chandler, M., Gellert, M., Lambowitz, A., Rice, P., and Sandmeyer S.B., ASM Press, Washington DC. Doi:10.1128/9781555819217. Also published in ASM Microbiology Spectrum 3 no. 2 doi:10.1128/microbiolspec.MDNA3-0057-2014. Bilanchone, V., Clemens, K., Kaake, R. Dawson, AR, Matheos, D., Nagashima, K. Sitlani, P., Patterson, K., Chang, I., Huang, L., and Sandmeyer, S. (2015) Ty3 Retrotransposon hijacks mating yeast RNA processing bodies to infect new genomes. PLoS Genetics: 11(9): e1005528. Doi:10.1371/journal.pgen.1005528. Qi, X., Vargas, E., Larsen, L., Hung, S-P., Lathrop, R., Hatfield, G.W., and Sandmeyer, S.B. (2013) Directed DNA shuffling of retrovirus and retrotransposon integrase protein domains PLoS ONE 8:e63957.doi:10.1371/journal.pone.0063957. Clemens*, K., Beliakova-Bethell*, N., Bilanchone, V., Larsen, L. Z., Nguyen, K., and Sandmeyer, S. B. Different sequence requirements for Ty3 RNA association with P-body proteins and packaging. (2013) Virus Research 171, 319-331. Qi X., and Sandmeyer S. (2013) Nonhomologous Recombination: Retrotransposons. In: Lennarz W.J. and Lane M.D. (eds.) The Encyclopedia of Biological Chemistry, vol. 3, pp. 283-291. Waltham, MA: Academic Press. Liu, P., Chernyshov, A., Najdi, T. Fu, Y., Dickerson, J., Sandmeyer, S., Jarboe, L. (2013) Membrane Stress Caused by Octanoic acid in Saccharomyces cerevisiae Applied Microbiology and Biotechnology 97:3239-3252. Qi, X. and Sandmeyer, S.B. In vitro targeting of strand transfer by the Ty3 retroelement integrase. (2012) J. Biol. Chem. 287, 18589-18595. PMCID 3365781