Qiao, Feng - University of California, Irvine - Department of Biological Chemistry

个人简介

Academic Distinctions 1. 2016 American Cancer Society Research Scholar 2. 2012 Basil O'Connor Starter Scholar Research Award, 2012 3. Life Sciences Research Foundation Postdoctoral Fellowship, 2006-2009 4. Distinguished Ph.D. Dissertation Award, UCLA, 2005 5. John M. Jordan Award for Excellence in Research, UCLA, 2004 Appointments Life Sciences Research Foundation Postdoctoral Fellow with Dr. Thomas R. Cech Howard Hughs Medical Institute/U. of Colorado-Boulder

研究领域

Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research. Specifically, we are interested in: • Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches. • Re-engineering/re-wiring telomere regulatory pathways using synthetic biology modules and concepts. • Chemical biology approach to identify small molecules that can inhibit telomere ON/OFF transition thereby inhibiting cancer cell progression.

近期论文

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Hu, X., Liu, J., Jun, H., Kim, J., and Qiao. F. (2016) “Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.” eLIFE 5:e15470 Wang, J, Cohen, A.L., Letian, A., Tadeo, X., Moresco, J.J., Liu, J., Yates III, J.R., Qiao. F., and Jia, S. (2016). “The proper connection between shelterin components is required for telomeric heterochromatin assembly.” Genes & Development 30(7):827-39 Liu, J., Yu, C., Hu, X., Kim, J., Bierma, J. C., Jun, H., Rychnovsky, S. D., Huang, L., and Qiao. F. (2015). “Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.” Cell Reports 12 (12) 2169-80 Tadeo, X., Wang, J., Kallgren, S.P., Liu, J. Reddy, B., Qiao, F. and Jia, S. (2013). “Elimination of shelterin subunits bypasses RNAi for pericentric heterochromatin assembly.” Genes & Development 27(22) 2489-99. Jun, H.I., Liu, J., Jeong, H., Kim, J.K., & Qiao, F. “Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1” Genes & Development 27:1917-1931 (2013) Qiao, F., Goodrich, K. J. and Cech, T. R., “Engineering cis-telomerase RNAs that add telomeric repeats to themselves”, Proc. Natl. Acad. Sci. [Direct submission] 107:4914-18 (2010) Qiao, F. and Cech, T. R., “Triple-helix structure in telomerase RNA contributes to catalysis”, Nature Structural & Molecular Biology, 15:634-40 (2008) Harada, B. T., Knight, M. J., Imai, S., Qiao, F., Ramachander, R., Sawaya, M. R., Gingery M., Sakane, F., and Bowie, J. U., “Regulation of Enzyme Localization by Polymerization: Polymer Formation by the SAM Domain of Diacylglycerol Kinase ?1”, Structure, 16:380-7 (2008) Qiao, F., Harada, B., Song, H., Whitelegge, J., Courey A. J., and Bowie J. U., “Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site”, EMBO J, 25:70-9 (2006)