Liu, Haoping - University of California, Irvine - Department of Biological Chemistry

研究领域

Candida albicans is one of the most frequently isolated fungal pathogens in humans. It causes a wide variety of infections ranging from mucosal infections in generally healthy people to life-threatening systemic infections in immunocompromised individuals. C. albicans is polymorphic and undergoes reversible morphogenetic transitions between budding, pseudohyphal and hyphal growth forms. Many signaling pathways that control the yeast-to-hyphal transition have been shown to be important for the virulence of C. albicans in mice. Therefore, a major emphasis of our research has been to understand how signaling pathways that are involved in the dimorphic regulation are regulated. Another emphasis is to identify the downstream targets of the signaling pathwaysimportant for hyphal morphogenesis.

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Liu, H., and Bretscher, A. (1989). Purification of tropomyosin from Saccharomyces cerevisiae and identification of related proteins in Schizosaccharomyces and Physarum. Proc Natl Acad Sci U S A 86, 90-93. Liu, H., and Bretscher, A. (1989). Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Cell 57, 233-242. Liu, H., and Bretscher, A. (1992). Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. J Cell Biol 118, 285-299. Liu, H., Krizek, J., and Bretscher, A. (1992). Construction of a GAL1-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast. Genetics 132, 665-673. Liu, H., Styles, C.A., and Fink, G.R. (1993). Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262, 1741-1744. Liu, H., Kohler, J., and Fink, G.R. (1994). Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266, 1723-1726. Liu, H., Styles, C.A., and Fink, G.R. (1996). Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144, 967-978. Loeb, J.D., Kerentseva, T.A., Pan, T., Sepulveda-Becerra, M., and Liu, H. (1999). Saccharomyces cerevisiae G1 cyclins are differentially involved in invasive and pseudohyphal growth independent of the filamentation mitogen-activated protein kinase pathway. Genetics 153, 1535-1546. Loeb, J.D., Sepulveda-Becerra, M., Hazan, I., and Liu, H. (1999). A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans. Mol Cell Biol 19, 4019-4027. Chen, J., Zhou, S., Wang, Q., Chen, X., Pan, T., and Liu, H. (2000). Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans. Mol Cell Biol 20, 8696-8708. Lane, S., Birse, C., Zhou, S., Matson, R., and Liu, H. (2001). DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans. J Biol Chem 276, 48988-48996. Lane, S., Zhou, S., Pan, T., Dai, Q., and Liu, H. (2001). The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1. Mol Cell Biol 21, 6418-6428. Liu, H. (2001). Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4, 728-735. Hazan, I., Sepulveda-Becerra, M., and Liu, H. (2002). Hyphal elongation is regulated independently of cell cycle in Candida albicans. Mol Biol Cell 13, 134-145.