Kaiser, Peter - University of California, Irvine - Department of Biological Chemistry

研究领域

Research in the Kaiser laboratory aims to (i) investigate fundamental mechanistic questions about cell cycle control and the ubiquitin-proteasome pathway, (ii) discover molecular pathways suitable for the development of novel strategies in cancer therapy, and (iii) develop novel approaches to directed drug design, which we apply to develop small molecules to reactivate mutant p53 in human cancer.

近期论文

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Lin DW, Chung BP. and Kaiser P. (2014). S-adenosylmethionine limitation induces p38 mitogen activated protein kinase and triggers cell cycle arrest in G1. J. Cell. Sci., 127, 50-59. Wassman C.D.*, Baronio R.*, Demir Ö.*, Wallentine B.D., Chen C.K., Hall L.V., Salehi F., Lin D.W., Chung B.P., Hatfield G.W., Chamberlin A.R., Luecke H. , Lathrop R.H., Kaiser P.*, Amaro R.E.* (2013). Computational Identification of a Transiently Open L1/S3 Pocket for p53 Cancer Mutant Reactivation. Nature Communications. 4, 1407. Booher K., Lin DW., Borrego SL and Kaiser P. (2012). Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle, 11, 4414 - 4423. Yen J. L.*, Flick K.*, Papagiannis C. V., Mathur R., Tyrrell A., Ouni I., Kaake R., Huang L. and Kaiser P., (2012) Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Molecular Cell. 48, 288-297. Ikram Ouni, Karin Flick and Peter Kaiser. (2010). A transcriptional activator is part of an SCF ubiquitin ligase to control degradation of its co-factors. Molecular Cell, 40, 954-964. An Tyrrell, Karin Flick, Gary Kleiger, Hongwei Zhang, Raymond J. Deshaies and Peter Kaiser (2010). A physiologically relevant and portable tandem ubiquitin-binding domain that stabilizes polyubiquitylated protein. Proc Natl Acad Sci U S A. 107, 19796-801. Wang X., Yen J., Kaiser P.* and Huang L*. (2010) Unraveling the Regulation of the 26S Proteasome Complex upon H2O2-induced Oxidative Stress. Science Signaling. 3, ra88. Aghajan M#., Jonai N. #, Flick K. #, Fu F., Luo M., Cai X., Ouni I.,Pierce N., Lomenick B. ,Damoiseaux R.,Hao R.,Verma R., Li Y., Houk K. N., Jung M. E., Huang L., Deshaies R. J., Kaiser P.* and Huang J.* (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nature Biotechnology. 7, 738-742. Baronio R., Danziger S.A., Hall L.V., Salmon K., Hatfield G.W., Lathrop R.H.*, and Kaiser P.*. (2010). All-codon Scanning identifies p53 cancer rescue mutations. Nucleic Acids Research. Danziger S. A., Baronio R., Ho L., Hall L.V., Salmon K., Hatfield G. W., Kaiser P.* and Lathrop R. H.* Predicting Positive p53 Cancer Rescue Regions Using Most Informative Positive (MIP) Active Learning.(2009). PLoS Computational Biology. 9.