Liu, Wendy - University of California, Irvine - Department of Biomedical Engineering

个人简介

Education B.S., Massachusetts Institute of Technology, Materials Science and Engineering Ph.D., The Johns Hopkins University, Biomedical Engineering

研究领域

Liu’s research is focused on understanding how microenvironmental cues regulate cell behavior in order to better understand and treat diseases of the cardiovasculature. The goals of her laboratory are to (1) develop tools using materials and microfabrication to manipulate the multicellular microenvironment, (2) utilize these technologies to understand how the physical and adhesive microenvironment regulate cell behavior, particularly those involved in atherosclerosis and the foreign body response to vascular implants, and (3) to design novel biomaterial systems for cardiovascular devices and tissue engineering with improved biocompatibility and integrated tissue function.

近期论文

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McWhorter F.Y., Smith T.D., Luu T.U., Rahim M.K., Haun J.B., Liu W.F. (2016) Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform. Integrative Biology. Advance article. doi:10.1039/C6IB00053C Alfonso García A., Smith T.D., Datta R., Luu T.U., Gratton E., Potma E.O., Liu W.F. (2016) Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 21(4):46007. doi:10.1117/1.JBO.21.4.046005 Wang T., Luu T.U., Chen A., Khine M., Liu W.F. (2016) Topographical modulation of macrophage phenotype by shrink film multi-scale wrinkles. Biomaterials Science. 4:948-52. doi:10.1039/C6BM00224B Luu T.U., Gott S.C., Woo B.W.K., Rao M.P., Liu W.F. (2015) Micro and nano-patterned topographical cues for regulating macrophage cell shape and phenotype. ACS Applied Materials and Interfaces. 7(51):28665-72. doi:10.1021/acsami.5b10589 Kim Y.K., Chen E.Y., Liu W.F. (2015) Biomolecular strategies to modulate the macrophage response to implanted materials. J. Mater. Chem. B. doi:10.1039/c5tb01605c McWhorter F.Y., Davis C.T., Liu W.F. (2015) Physical and mechanical regulation of macrophage phenotype and function. Cell Mol. Life Sci. 72(7):1303-16. doi:10.1007/s00018-014-1796-8 Harker KS, Jivan E, McWhorter FY, Liu WF, Lodoen MB. (2014) Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium. MBio. 5(2): 01111-13. doi:10.1128/mBio.01111-13 Kim YK, Que R, Wang SW, Liu WF. (2014) Modification of Biomaterials with a Self-Protein Inhibits the Macrophage Response. Adv. Healthcare Mat. Feb 20. doi:10.1002/adhm.201300532 Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. (2013) Real-time imaging of infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. Dec 4. doi:10.1111/cmi.12239 McWhorter FY*, Wang T*, Nguyen P, Chung T, Liu WF. (2013) Modulation of macrophage phenotype by cell shape. Proc Nat Acad Sci USA. doi:10.1073/pnas.1308887110. Download Harker K.S., Ueno N., Wang T., Bonhomme C., Liu W., Lodoen M.B. (2013) Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 93(5)789-800. Dheda S.S., Kim Y.K., Melnyk C., Liu W., Mohamed F.A. (2013) Corrosion and in vitro biocompatibility properties of cryomilled-spark plasma sintered commercially pure titanium. J Mater Sci Mater Med. 24(5):1239-49. Alavi S.H., Liu W.F., Kheradvar A. (2013) Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet. Ann Biomed Eng. 42(2):316-26.