Khine, Michelle - University of California, Irvine - Department of Biomedical Engineering

个人简介

Prior to UC Irvine, Khine was an assistant and founding professor at UC Merced from 2006-09. At UC Merced, Shrink Nanotechnologies Inc., the first start-up company from youngest UC campus, was spun out of the research developed in Khine’s lab. Khine received both her B.S. (1999) and M.S. (2001) degrees in mechanical engineering from UC Berkeley. She received her Ph.D. (2005) in bioengineering from UC San Francisco and UC Berkeley. In the Berkeley Sensor and Actuator Center under Professor Luke P. Lee, Ph.D., Khine focused on developing microfabricated polymeric devices for cellular manipulation and analyses. As a Microsystems and Engineering Applications Institute Fellow, she also concurrently worked at Sandia National Laboratory. While in graduate school, she spun out a company, Fluxion Biosciences (San Francisco), based on her dissertation work of single-cell electroporation.

研究领域

Current research projects include: Single Cell Electroporation Shrinky-Dink Microfluidics Microsystems for Stem Cell Differentiation Canary on a Chip Quantitative Single-Cell Analysis of Receptor Dynamics and Chemotactic Response on a Chip

近期论文

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Park, S.J., Kim, J., Chu, M., Khine, M Highly Flexible Wrinkled Carbon Nanotube Thin Film Strain Sensors to Monitor Human Movement, Adv. Mater. Tech. Lin, S., Hedde, P. N., Venugopalan, V., Gratton, E., and Khine, M. Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection, Analyst (2016). doi:10.1039/C6AN00519E Luu, W.T., Chen, A., Khine, M., and Liu, W. Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles, Biomater. Sci. (2016). 4, 948-952 doi:10.1039/C6BM00224B Nokes, J.M., Sharma, H., Tu, R., Kim, M.Y., Chu, M., Siddiqui, A., and Khine, M. Nanotextured Shrink Wrap Superhydrophobic Surfaces by Argon Plasma Etching, Materials (2016), 9(3). doi:10.3390/ma9030196 Sharac, N., Sharma, H., Veysi, M., Sanderson, R.N., Khine, M., Capolino, F., and Ragan, R. Tunable optical response of bowtie nanoantenna arrays on thermoplastic substrates, (2016). Nanotechnology 27 Kim, J., Park, S.-J., Nguyen, T., Chu, M., Pegan, J. D., and Khine, M., Highly stretchable wrinkled gold thin film wires, Appl. Phys. Lett., (2016). DOI: http://dx.doi.org/10.1063/1.4941439 Nokes, J. M., Liedert, R., Kim, M. Y., Siddiqui, A., Chu, M., Lee, E.K., and Khine, M., Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics, Adv. Healthcare Mater., (2016). DOI: 10.1002/adhm.201500697 Lee, E.K., Kurokawan Y.K., Tu, R., George, S. C., and Khine, M. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs, Scientific Reports, (2015). DOI: 10.1038/srep11817 M. Leser, J. Pegan, M. El Makkaoui, J. C. Schlatterer, M. Khine, M. Law and M. Brenowitz, Protein footprinting by pyrite shrink-wrap laminate, Lab Chip, (2015). DOI: 10.1039/C4LC01288G Lin, S., Lee, E., Nguyen, N., Khine, M., Thermally-induced miniaturization for micro- and nanofabrication: progress and updates, Lab Chip, (2014). Sharma, H., Wood, J., Lin, S., Corn, R., Khine, M., Shrink-Induced Silica Multi-Scale Structures for Enhanced Fluorescence from DNA Microarrays, Langmuir, (2014). McLane, J., Wu, C., Khine, M., Enhanced Detection of Protein in Urine by Evaporation on a Superhydrophobic Plastic, Advanced Materials Interfaces, (2014). Sharma H., Digman M., Felsinger N., Gratton E., and Khine M., Enhanced emission of fluorophores on shrink-induced wrinkled composite structures, Opt. Mater. Express 4, 753-763 (2014) Chen, A., Lee, E., Tu, R., Santiago, K., Grosberg, A., Fowlkes, C., Khine, M. (2013) Integrated Platform for Functional Monitoring of Biomimetic Heart Sheets Derived From Human Pluripotent Stem Cells. Biomaterials. Wang, J., Chen, A., Lieu, D.K., Karakikes, I., Chen, G., Keung, W., Chan, C.W., Hajjar, R.J., Costa, K.D., Khine, M., Li, R.A. (2013) Effect of Engineered Anisotropy on the Susceptibility of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes to Arrhythmias. Biomaterials. 34(35): 8878-8886.