Brody, James - University of California, Irvine - Department of Biomedical Engineering

个人简介

Education M.S., Princeton University, Physics, 1991 Ph.D., Princeton University, Physics, 1994 B.S., Massachusetts Institute of Technology, Physics, 1989

研究领域

Research in Dr. Brody's laboratory focuses on functional genomics and single molecule protein characterization. Specific research projects include: application of surface plasmon resonance based sensors to quantifying DNA/protein interactions, studies of single proteases and 20 S proteasomes in vitro, and molecular biology and biochemical analysis of a module of genes expressed in breast cancers.

近期论文

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Trevor Sughrue, Michael A. Swiernik, Yang Huang and James P. Brody, “Laboratory tests as short-term correlates of stroke,” BMC Neurology (2016) 16:112. Trevor Sughrue and James P. Brody, “Breast tumor laterality in the United States depends upon the country of birth, but not race,” PLoS One 9 (8) 2014. James P. Brody, “The age-specific incidence anomaly suggests that cancers originate during development.” Biophysical Review and Letters, 1-12, 2014. Luis Soto-Ortiz and James P. Brody, “Similarities in the Age-Specific Incidence of Colon and Testicular Cancers” PLoS One. 2013 Jun 26; 8(6) ee66694 Luis Soto-Ortiz and James P. Brody, “A theory of the cancer age-specific incidence data based on extreme value distributions,” AIPAdvances 2, 011205, 2012. James P. Brody. “RPN8,” Encyclopedia of Signaling Molecules, p 1691. (2012). James P. Brody, “Age-specific incidence data indicate four mutations are required for human testicular cancers.“, PLoS One. 2011;6(10):e25978. Epub 2011 Oct 6 Grace Mao and James P. Brody, “Reverse engineering the yeast RNR1 transcriptional control system.“, PLoS One. 2010 Nov 16;5(11):e13895. James P. Brody, “Parallel Routes of Human Carcinoma Development: Implications of the Age-Specific Incidence Data“, PLoS ONE, 4(9): e7053, doi:10.1371/journal.pone.0007053, 2009. Angela Y Chen, Ashish S. Jani, Lifeng Zheng, Peter J. Burke, and James P. Brody, “Microfabricated Arrays of Cylindrical Wells Facilitate Single-Molecule Enzymology of alpha Chymotrypsin“, Biotechnology Progress, 2009, 25: 929–937. Bobak Mosadegh, Carlos Huang, Jeong Park, Hwas Sung Shin, Bong Geun Chung, Kun-Hong Lee; Sun-Kyu Hwang, Hyung Joon Kim, James Brody, Noo Li Jeon, “Generation of Stable Complex Gradients Across 2D Surfaces and 3D Gels”, Langmuir, 2007, 23(22) 10910-10912. Grace Mao and James P. Brody, Dynamic SPR monitoring of yeast nuclear protein binding to a cis-regulatory element. Biochemical and Biophysical Research Communications 363 p153–158, 2007. Limin Lin and James P. Brody, Analyzing DNA-Protein Interactions on a Chip. Chapter 10 in Integrated Biochips for DNA Analysis, Landes Biosciences, 2007. Alan I. Lee and James P. Brody, Diversity in the activity of individual enzymes., Current Pharmaceutical Biotechnology, 6, p 415–25, 2005. H. Garrett R. Thompson and James P. Brody. Rpn8, AfCS-Nature Molecule Pages, (doi:10.1038/mp.a003584.01) 2005.