Read, Elizabeth - - Department of Molecular Biology and Biochemistry

个人简介

Education Ph.D., University of California, Berkeley, Physical Chemistry, 2008 B.A., University of Colorado, Boulder, Chemistry, 2003 B.A., University of Colorado, Boulder, Mathematics, 2003

研究领域

We use computational approaches from engineering and the physical sciences to study biological processes relevant to human health. Biological systems are exceedingly complex: they are multi-scale, nonlinear, and subject to noise at the molecular level. This complexity means that computer models are vital for uncovering mechanistic principles based on varied experimental data. Our focus is immune system dynamics and regulation. A major goal is to develop computer simulation tools that can predict therapeutic interventions to treat or prevent disease.

近期论文

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B. K. Chu, M. J. Tse, R. R. Sato, E. L. Read. Markov State Models of gene regulatory networks. BMC Systems Biology 11:14 (2017). Y. Vodovotz, A. Xia, E. L. Read, J. Bassaganya-Riera, D. A. Hafler, E. Sontag, J. Wang, J. S. Tsang, J. D. Day, S. H. Kleinstein, A. J. Butte, M. C. Altman, R. Hammond, S. C. Sealfon. Solving Immunology? Trends in Immunology 38(2) (2017). T. D. Smith, M. J. Tse, E. L. Read, W. F. Liu. Regulation of macrophage polarization and plasticity by complex activation signals. Integr. Biol. 8, 946-955 (2016). M. J. Tse, B. K. Chu, M. Roy, E. L. Read. DNA-binding kinetics determines mechanism of noise-induced switching in gene networks, Biophys. J. 109(8), 1746-1757 (2015). Named a Best of 2015 article E. L. Read, A. A. Tovo-Dwyer, A. K. Chakraborty. Stochastic effects are important in intrahost HIV evolution even when viral loads are high. Proc. Natl. Acad. Sci. 109, 19727-19732 (2012). A. Košmrlj*, E. L. Read*, Y. Qi, T. M. Allen, M. Altfeld, S. G. Deeks, F. Pereyra, M. Carrington, B. D. Walker, A. K. Chakraborty. Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature 465, 350-354 (2010). G. S. Schlau-Cohen, T. R. Calhoun, N.S. Ginsberg, E. L. Read, M. Ballottari, R. Bassi, R. van Grondelle, G. R. Fleming. Pathways of energy flow in LHCII from two-dimensional electronic spectroscopy. J. Phys. Chem. B 113, 15352-15363 (2009). E. L. Read, H. Lee, G. R. Fleming. Photon echo studies of photosynthetic light harvesting. Photos. Res. 101, 233-243 (2009). E. L. Read, G. S. Schlau-Cohen, G. S. Engel, T. Georgiou, M. Z. Papiz, G. R. Fleming. Pigment organization and energy level structure in Light-harvesting Complex 4: Insights from two-dimensional electronic spectroscopy. J. Phys. Chem. B 113, 6495-6504 (2009). E. L. Read, G. S. Schlau-Cohen, G. S. Engel, R. E. Blankenship, G. R. Fleming. Visualization of excitonic structure in the Fenna-Matthews-Olson photosynthetic complex by polarization-dependent two-dimensional electronic spectroscopy. Biophys. J. 95, 847-856 (2008). D. Zigmantas, Y.-Z. Ma, E. L. Read, G. R. Fleming. Nonlinear femtosecond optical spectroscopy techniques in photosynthesis. In: Biophysical Techniques in Photosynthesis, Vol. II, T. J. Aartsma and J. Matysik, eds. Springer, 201-222 (2008).