Martin, Rachel - University of California, Irvine - Department of Molecular Biology and Biochemistry

个人简介

Appointments Postdoctoral researcher, University of California, Berkeley, 2002-2005

研究领域

We develop and use modern NMR methods to investigate biological macromolecules, including membranes and membrane proteins, disease-related and functional protein aggregates, and other locally ordered protein networks. Locally ordered protein networks are biomaterials that have significant short-range order but lack long-range crystallinity. Although these materials are difficult to study because of their compositional heterogeneity, they are central to many interesting biophysical questions. Graduate and undergraduate students are involved in all aspects of this research, including design and construction of NMR equipment, development of pulse sequences, and preparation of protein and membrane samples.

近期论文

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Kingsley, C. N., Bierma, J. C., Pham, V., Martin, R. W. The γS-crystallin Proteins From the Antarctic Nototheniid Toothfish: a Model System for Investigating Differential Resistance to Chemical and Thermal Denaturation. The Journal of Physicl Chemistry B. 118(47):13544-53. Martin, R. W. (2014). NMR studies of eye lens crystallins. In R. K. Harris, R. Wasylishen (Eds.), eMagRes (Encyclopedia of NMR). Southern Gate, Chichester, West Sussex, PO19 8SQ, United Kingdom. John Wiley & Sons, Ltd. Kingsley, C. N., Brubaker, W. D., Markovic, S., Diehl, A., Brindley, A. J., Oschkinat, H., Martin, R. W. (2013). Preferential and specific binding of human αB-crystallin to a cataract-related variant of γS-crystallin. Structure, 12(12), 2221-2227. (Featured on the cover). Jiang, J., Golchert, K. J., Kingsley, C. N., Brubaker, W. D., Martin, R. W., Mukamel, S. (2013). Exploring the aggregation propensity of γS-crystallin protein variants using two- dimensional spectroscopic tools. Journal of Physical Chemistry B, 117(46), 14294-14301. Donovan, K. J., Allen, M. A., Martin, R. W., Shaka, A. J. (2012). Improving the double quantum ltered COSY experiment by "Moving Tube NMR". Journal of Magnetic Resonance, 219, 41-45. (Featured on the cover). Brindley, A. J., Martin, R. W. (2012). Effect of divalent cations on DMPC/DHPC bicelle formation and alignment. Langmuir, 28(20), 7788-7796. Thureau, P., Ziarelli, F., Thevand, A., Martin, R. W., Farmer, P. J., Viel, S., Mollica, G. (2012). Probing motional behavior of eumelanin and pheomelanin by solid-state NMR: new insights into the pigment properties. Chemistry - A European Journal, 18, 10689-10700. Brubaker, W. D., Martin, R. W. (2012). 1H, 13C, and 15N assignments of wild-type human γS-crystallin and its cataract-related variant γS-G18V. Biomolecular NMR Assignments, 6(1), 63-67. Espinosa, C. A., Thureau, P., Shapiro, R. A., Livak, I. M., Martin, R. W. (2011). Modulation of cross polarization in motionally averaged solids by Variable Angle Spinning NM. Chemical Physics Letters, 508(4-6), 314-319. Brubaker, W. D., Freites, J. A., Golchert, K. J., Shapiro, R. A., Morikis, V., Tobias, D. J., Martin, R. W. (2011). Separating instability from aggregation propensity in γS-crystallin variants. Biophyical Journal, 100, 498-506. Nowacka, A., Mohr, P., Norrman, J., Martin, R. W. (2010). Polarization transfer solid-state NMR for studying amphiphiles in coexisting solid and liquid crystalline phases. Langmuir, 26, 16848-16856. Litvak, I. M., Espinosa, C. A., Shapiro, R. A., Oldham, A. N., Duong, V. V., Martin, R. W. (2010). Pneumatic switched angle spinning NMR probe with capacitively coupled double saddle coil. Journal of Magnetic Resonance. 206(2), 183-189.