Kwon, Young Jik - University of California, Irvine - Department of Molecular Biology and Biochemistry

个人简介

Brain Pool scholar and visiting professor, Chemical and Biomolecular Engineering, Korea University, Korea (2015 – 2016) Special visiting research fellow (Science without Borders Scholar), College of Pharmacy, Federal University of Minas Gerais, Brazil (2015 – 2017) Top downloaded article award in 2014, Journal of Materials Chemistry, Royal Society of Chemistry Publishing (2015) Top-cited article award, FEBS Journal, Wiley (2013) Medical Research Award, Gabrielle's Angel Foundation for Cancer Research (2011) Faculty Early Career Development (CAREER) Award, National Science Foundation (2010) Faculty Career Development Award, UC Irvine (2008) M. Frank and Margaret Domiter Rudy Assistant Professor of Biomedical Engineering in Cancer Research, Case Western Reserve University (2006-2007)

研究领域

Gene therapy, drug delivery, cancer-targeted therapeutics, combined molecular imaging and therapy, cancer vaccine

近期论文

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Soo Kyung Cho, Young Jik Kwon*. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials 33, 3316-3323 (2012). Young Jik Kwon*. Before and after endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Accounts of Chemical Research 45, 1077-1088 (2012) (Invited review) Min Suk Shim, Young Jik Kwon*. Stimuli-responsive gene delivery and combined imaging. Advanced Drug Delivery Reviews 64, 1046-1059 (2012) (Invited review). Min Suk Shim, Shirley Wong, Young Jik Kwon*. siRNA as a conventional drug in the clinic? Challenges and Current Technologies. Drug Discovery Today Technologies 9, 167-173 (2012) (Invited review). Min Suk Shim, Young Jik Kwon*. Ketalized poly(amino ester) for stimuli-responsive and biocompatible gene delivery. Polymer Chemistry 3, 2570-2577 (2012). Marlon Mathews*, En-Chung Shih, Genesis Zamora, Chung-Ho Sun, Soo Kyung Cho, Young Jik Kwon, Henry Hirschberg. Glioma cell growth inhibition following photochemical internalization enhanced PTEN gene transfection. Lasers in Surgery and Medicine 44, 746-754 (2012). Soo Kyung Cho, Young Jik Kwon*.Synthetically engineered viruses: Can synthetic chemistry tame the nature? Current Opinion in Solid State & Materials Science 16, 276-286 (2012) (Invited review). Min Sun Song, Seung Phill Choi, Young Jik Kwon, Sang Jun Sim*. Real time, sensitive, and specific detection of promoter-polymerase interactions in gene transcription using a nanoplasmonic sensor. Advanced Materials 25, 1265-1269 (2013) (Cover article). Chang Soo Kim, Wenjuan Qi, Jun Zhang, Young Jik Kwon*, Zhongping Chen*. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase resolved Doppler variance optical coherence tomography. Journal of Biomedical Optics 18, 030504 (2013). Soo Kyung Cho, Ali Pedram, Ellis R. Levin*, Young Jik Kwon*. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials 34, 10228-10237 (2013). Min Suk Shim, Seong-Sil Chang, Young Jik Kwon*. Efficient gene silencing in tumor via systemic delivery of stimuli-responsive siRNA carriers. Biomaterials Science 2, 35-40 (2014). Shirley Wong, Min Suk Shim, Young Jik Kwon*. Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications. Journal of Materials Chemistry B: Materials for biology and medicine 2, 595-615 (2014) (invited review) (cover article). Frederick Wang,* Genesis Zamora, Chung-Ho Sun, Anthony Trinidad, Changho Chun, Young Jik Kwon, Kristian Berg, Steen J. Madsen, Henry Hirschberg. Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene. Journal of Neurooncology 118, 29-37 (2014).