Whiteson, Katrine - University of California, Irvine - Department of Molecular Biology and Biochemistry

个人简介

August 2008 – August 2011 Research Scientist, (30% time) University of Geneva (Prof. Jacques Schrenzel,MD and Prof. Patrice Francois, PhD, Genomic Research Lab) Sept. 2011- August 2014 Post-doc/Adjunct Faculty, San Diego State University (Prof. Forest Rohwer, PhD)

研究领域

I am a biochemist interested in human associated microbial and viral communities. I use metagenomics, metabolomics, microbial genetics and ecological statistics to answer questions about how microbes and viruses affect human health. I am interested in understanding how individual and persistent human-associated microbial and viral communities affect health. Infection with a bacterial pathogen, vaccination, immune development and even taking a Tylenol does not occur in a vacuum. Dynamic microbial and viral communities constantly inhabit our bodies, encoding the majority of the unique genes that alter these processes. Resident microbial and viral community composition is unique to each human. Specifically, I am working to understand the role of persistent microbial colonization in triggering inflammatory episodes in Cystic Fibrosis patients. Understanding microbial interactions and changes in microbial physiology that are associated with changes in patient status may lead to the development of biomarkers to diagnose changes in infection earlier and more specifically. I am also interested in how phage shape dynamic host-associated microbial communities, and in characterizing the function of the 70% of phage encoded genes with no known function.

近期论文

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Phan, J., Meinardi, S., Barletta, B., Blake, D., and Whiteson, K. (2017) Stable isotope profiles reveal active production of VOCs from human-associated microbes. Journal of Breath Research (accepted). Bos, L. D. J., Meinardi, S., Blake, D., and Whiteson, K. (2016) Bacteria in the airways of patients with cystic fibrosis are genetically capable of producing VOCs in breath. J. Breath Res. 10, 047103. http://iopscience.iop.org/article/10.1088/1752-7163/10/4/047103/meta Quinn, R. A., Whiteson, K., Lim, Y. W., Zhao, J., Conrad, D., LiPuma, J. J., Rohwer, F., and Widder, S. (2016) Ecological networking of cystic fibrosis lung infections. npj Biofilms and Microbiomes 2, 4. http://www.nature.com/articles/s41522-016-0002-1 Quinn, R. A., Lim, Y. W., Mak, T. D., Whiteson, K., Furlan, M., Conrad, D., Rohwer, F., and Dorrestein, P. (2016) Metabolomics of pulmonary exacerbations reveals the personalized nature of cystic fibrosis disease. PeerJ 4, e2174. https://peerj.com/articles/2174/ Quinn, R. A., Phelan, V. V., Whiteson, K., Garg, N., Bailey, B. A., Lim, Y. W., Conrad, D. J., Dorrestein, P. C., and Rohwer, F. L. (2015) Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome. ISME J. 10.1038/ismej.2015.207 [Epub ahead of print] http://www.nature.com/ismej/journal/v10/n6/full/ismej2015207a.html Quinn, R.A, Whiteson, K., Lim, Y.W., Conrad, D., Candido, A., Salamon, P., and Rohwer, F. (2015) A Winogradsky-Based Culture System Shows an Association between Microbial Fermentation and Cystic Fibrosis Exacerbation. ISME Journal. 9(4):1024-38. http://www.nature.com/ismej/journal/v9/n4/full/ismej2014266a.html Whiteson K.L., Lazarevic V., Tangomo M., Girard M., Francois P., Schrenzel J. and the GESNOMA study group (2014). NOMA affected children from Niger have distinct oral microbial communities. Plos Neglected Tropical Disease, 8(12):e3240. http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003240 Whiteson, K., Bailey, B., Bergkessel, M., Conrad, D., Delhaes, L., Felts, B., J. Kirk Harris, R. Hunter, Y.W. Lim, H. Maughan, R. Quinn, P. Salamon, J. Sullivan, B.D. Wagner, P.B. Rainey (2014). The upper respiratory tract as a microbial source for pulmonary infections: Parallels from Island Biogeography. Am J Respir Crit Care Med. 189(11):1309-15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098084/ Quinn, R.A., Hester, E., Lim, Y.W. , Conrad, D., Rohwer, F., and Whiteson, K. (2014) Biogeochemical forces shape the composition and physiology of polymicrobial communities in the Cystic Fibrosis lung. mBio 18;5(2):e00956-13. http://mbio.asm.org/cgi/pmidlookup?view=long&pmid=24643867 *** highlighted in several news articles and blogs: Molloy, S. A metabolic milieu. Nature Reviews Microbiology 12, 315 (2014); *** http://www.altmetric.com/details.php?citation_id=2195399