Razorenova, Olga - University of California, Irvine - Department of Molecular Biology and Biochemistry

研究领域

My research interests include molecular, cellular and genetic basis of cancer. Dissection of mechanisms of tumor initiation and progression based on mouse models of ovarian and breast cancers. Primary focus is on the role of hypoxia and tumor micro-environment in the progression and metastatic spread of epithelial tumors. Additional area of expertise includes small molecule chemical library screens to identify anti-cancer drugs in multiple cell reporter based assays and the use of synthetic lethality concept.

近期论文

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Hou J., Wright H.J., Chan N., Tran R., Razorenova O.V., Potma E.O., Tromberg B.J. Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption. J Biomed Opt. 2016; 21(6):60503. Thompson J.M., Nguyen Q.H., Singh M., Pavesic M.W., Nesterenko I., Nelson L.J., Liao A., Razorenova O.V.* Rho-Associated Kinase 1 (ROCK1) inhibition is synthetically lethal with Von Hippel Lindau (VHL) deficiency in Clear Cell Renal Cell Carcinoma (CC-RCC). Oncogene. 2016; in press. * - corresponding author Wright H.J., Arulmoli J., Motazedi M., Nelson L.J., Heinemann F.S., Flanagan L.A., Razorenova O.V.* CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene. 2016; in press. Thompson JM, Nguyen QH, Singh M, Razorenova OV.* Approaches to identifying synthetic lethal interactions in cancer. Yale J Biol Med;88(2):145-55. Review. Razorenova O.V.*, Castellini L.*, Colavitti R.*, Edgington L.E., Nicolau M., Huang X., Bedogni B., Mills E.M., Bogyo M., Giaccia A.J. The Apoptosis Repressor with a CARD Domain (ARC) is a Direct HIF1 Target Gene and Promotes Survival and Proliferation of VHL Deficient Renal Cancer Cells. Mol Cell Biol. 2014; 34(4):739-751. Razorenova O.V.* Brain and Muscle ARNT-Like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to Hypoxia Inducible Factor mediated pathway. Cell Cycle. 2012; 11(2):213-214. Invited News and Views. Razorenova O.V., Finger E., Colavitti R., Chernikova S.B., Boiko A.D., Chan C., Krieg A.J., Bedogni B., LaGory E., Weissman I.L., Broome-Powell M., Giaccia A.J. VHL loss in renal cell carcinoma leads to HIF-dependent upregulation of CUB domain-containing protein 1 to stimulate PKCdelta-driven migration. Proc Natl Acad Sci USA. 2011; 108(5):1931-1936.