Luecke, Hartmut - University of California, Irvine - Department of Molecular Biology and Biochemistry

研究领域

Protein crystallography Structure function studies Membrane proteins Bacteriorhodopsin Annexin G protein-coupled receptors (GPCR) Structure-based drug design

近期论文

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A transporter converted into a sensor, a phototaxis signaling mutant of bacteriorhodopsin at 3.0 Å. Spudich EN, Ozorowski G, Schow EV, Tobias DJ, Spudich JL, Luecke H. J Mol Biol. 2012 Jan 20;415(3):455-63. Epub 2011 Nov 22. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9449-54. Epub 2011 May 23. Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization. Stagno J, Aphasizheva I, Bruystens J, Luecke H, Aphasizhev R. J Mol Biol. 2010 Jun 11;399(3):464-75. Epub 2010 Apr 18. Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia. Pathuri P, Nguyen ET, Ozorowski G, Svärd SG, Luecke H. J Mol Biol. 2009 Jan 30;385(4):1098-112. Epub 2008 Nov 20. Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore. Luecke H, Schobert B, Stagno J, Imasheva ES, Wang JM, Balashov SP, Lanyi JK. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16561-5. Epub 2008 Oct 15. Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form. Pathuri P, Vogeley L, Luecke H. J Mol Biol. 2008 Oct 31;383(1):62-77. Epub 2008 May 7.