个人简介

Ph.D. (Chemical Engineering), Cornell University, 1995 M.S. (Chemical Engineering), Cornell University B.S. (Chemical Engineering), University of Kansas

研究领域

Biochemical Engineering, Metabolic Engineering

Production of pharmaceutical compounds from cell culture Plant cell and tissue culture Microalgae for the production of biofuel Prof. Lee-Parson’s research is in biochemical engineering, specifically the area of metabolic engineering. Metabolic engineering embodies the principles, framework, and methodologies for understanding and manipulating the metabolic pathways in the cell for targeted and improved chemical transformations. Prof. Lee-Parson’s research group is applying metabolic engineering principles and methodologies to improve the production of important compounds from plants or plant cell cultures. The lab’s research relies heavily on understanding the complex network of biosynthetic reactions within the cell and the application of tools in analytical chemistry for unveiling the secrets of the cell. The outcome of this research is an understanding of how to rationally direct the resources of the cell (i.e. precursor and energy fluxes) for significant enhancements in the production of the desired chemical compound. Prof. Lee-Parson’s research is being applied to address: Focus 1: the production of cost-prohibitive pharmaceutical compounds from cell cultures of plants. Focus 2: the growing problem of antibiotic resistance using plant-derived compounds to inhibit bacterial defense mechanisms. Focus 3: the efficient cultivation of plants with high nutritional quality for food, in environments with limited gas exchange such as those found on space stations Prof. Lee-Parson’s main research focus is the production of valuable pharmaceutical compounds from plant cell cultures, specifically the production of important anti-cancer drug molecules from cell cultures of Catharanthus roseus. Plant cell culture is potentially a better route for supplying certain structurally complex drug molecules than chemical synthesis or extraction from whole plants. Moreover, plant cell culture can potentially produce these drug molecules at a faster and more consistent rate than whole plants. The overall vision of Prof. Lee-Parson’s research is to meet the needs and demands of important and cost-prohibitive plant-derived pharmaceuticals using plant cell culture, applying metabolic engineering strategies and ultimately developing an economically viable process using plant cell culture.

近期论文

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An efficient transformation method for estrogen-inducible transgene expression in Catharanthus roseus hairy roots NF Rizvi, M Cornejo, K Stein, J Weaver, EJ Cram, CWT Lee-Parsons Plant Cell, Tissue and Organ Culture (PCTOC) 120 (2), 475-487 Optimizing the transient Fast Agro-mediated Seedling Transformation (FAST) method in Catharanthus roseus seedlings J Weaver, S Goklany, N Rizvi, EJ Cram, CWT Lee-Parsons Plant cell reports 33 (1), 89-97 Jasmonate‐dependent alkaloid biosynthesis in Catharanthus Roseus hairy root cultures is correlated with the relative expression of Orca and Zct transcription factors S Goklany, NF Rizvi, RH Loring, EJ Cram, CWT Lee‐Parsons Biotechnology progress 29 (6), 1367-1376 Rapid Increases of Key Regulators Precede the Increased Production of Pharmaceutically Valuable Compounds in Catharanthus roseus N Rizvi, S Goklany, EJ Cram, CWT Lee-Parsons Pharmaceutical Engineering 33 (6), 1-8 Application of an integrated LC-UV-MS-NMR platform to the identification of secondary metabolites from cell cultures: benzophenanthridine alkaloids from elicited Eschscholzia californica (california poppy) cell cultures RM Gathungu, JT Oldham, SS Bird, CWT Lee-Parsons, P Vouros, R Kautz Analytical Methods 4 (5), 1315-1325 Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-β-cyclodextrin M Shulman, M Cohen, A Soto-Gutierrez, H Yagi, H Wang, J Goldwasser, ... PloS one 6 (4), e18033 Shotgun proteomic analysis of yeast-elicited California poppy (Eschscholzia californica) suspension cultures producing enhanced levels of benzophenanthridine alkaloids JT Oldham, M Hincapie, T Rejtar, PK Wall, JE Carlson, CWT Lee-Parsons Journal of proteome research 9 (9), 4337-4345 Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catharanthus roseus hairy root cultures through gene expression profiling and precursor feeding S Goklany, RH Loring, J Glick, CWT Lee‐Parsons Biotechnology progress 25 (5), 1289-1296 Synergistic effects of sequential treatment with methyl jasmonate, salicylic acid and yeast extract on benzophenanthridine alkaloid accumulation and protein expression in Eschscholtzia californica suspension cultures HY Cho, SY Son, HS Rhee, SYH Yoon, CWT Lee-Parsons, JM Park Journal of biotechnology 135 (1), 117-122 Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholtzia californica suspension cultures HY Cho, CWT Lee-Parsons, SYH Yoon, HS Rhee, JM Park Biotechnology letters 29 (12), 2001-2005 Gas composition strategies for the successful scale-up of Catharanthus roseus cell cultures for the production of ajmalicine CWT Lee-Parsons Phytochemistry Reviews 6 (2-3), 419-433 Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures CWT Lee-Parsons, AJ Royce Plant cell reports 25 (6), 607-612 Ajmalicine production in methyl jasmonate-induced Catharanthus roseus cell cultures depends on Ca2+ level CWT Lee-Parsons, S Ertürk Plant cell reports 24 (11), 677-682 Sparge gas composition affects biomass and ajmalicine production from immobilized cell cultures of Catharanthus roseus CWT Lee-Parsons, ML Shuler Enzyme and microbial technology 37 (4), 424-434 Biochemical engineering taught in the context of drug discovery to manufacturing CWT Lee-Parsons Chemical Engineering Education 39 (3), 208-215, 221 Improved ajmalicine production and recovery from Catharanthus roseus suspensions with increased product removal rates PL Wong, AJ Royce, CWT Lee-Parsons Biochemical engineering journal 21 (3), 253-258 Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation CWT Lee-Parsons, S Ertürk, J Tengtrakool Biotechnology letters 26 (20), 1595-1599 Poly (ethylene glycol)-modified gelatin nanoparticles for intracellular delivery G Kaul, C Lee-Parsons, M Amiji PHARMACEUTICAL ENGINEERING 23 (5), 108-117 Perm-selective chitosan-alginate hybrid microcapsules for enzyme immobilization technology E Taqieddin, C Lee, M Amiji Pharmaceutical Engineering 22 (6), 112-114 The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures CWT Lee‐Parsons, ML Shuler Biotechnology and bioengineering 79 (4), 408-415