研究领域
Structural and biochemical studies of molecular assemblies in Mycobacterium tuberculosis
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Unraveling the essential role of CysK in CDI toxin activation. Johnson, P. M., Beck, C. M., Morse, R. P., Garza-Sánchez, F., Low, D. A., Hayes, C. S., Goulding, CW. Proc Natl Acad. Sci, (2016) 0027-8424. doi: 10.1073/pnas.1607112113.
Functional Diversity of Cytotoxic tRNase/immunity Protein Complexes from Burkholderia pseudomallei. Johnson, P. M., Gucinski, G. C., Garza-Sánchez, F., Wong, T., Hung, L. W., Hayes, C. S., Goulding, CW. J Biol Chem. 2016, 0021-9258. doi: 10.1074/jbc.M116.736074
Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation Matsui T, Nambu S, Goulding CW, Takahashi S, Fukii H, Ikeda-Saito M. Proc Natl Acad. Sci, 2016, Mar 22, epub
Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated. Diaz-Ochoa, V. E., Lam, D., Lee, C. S., Klaus, S., Behnsen, J., Liu, J. Z., Chim, N., Nuccio, S. P., Rathi, S. G., Mastroianni, J. R., Edwards, R. A., Jacobo, C. M., Cerasi, M., Battistoni, A., Ouellette, A. J., Goulding, CW., Chazin, W. J., Skaar, E. P., Raffatellu, M. (2016). Cell PMID:27006503Host Microbe. 2016 Jun 8;19(6):814-25. doi: 10.1016/j.chom.2016.05.005.
Diversification of ß-augmentation interactions between CDI toxin/immunity proteins. Morse RP, Willett JL, Johnson PM, Zheng M, Credali A, Iniguez A, Nowick JS, Hayes CS, Goulding CW J Mol Biol. 2015, 427 (23): 3766-84
The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis. Chim N, Torres R, Liu Y, Capri J, Batot G, Whitelegge JP, Goulding CW. Chem Biol. 2015 Aug 20;22(8):1098-107
Fe(2+) substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization. Behera RK, Torres R, Tosha T, Bradley JM, Goulding CW, Theil EC. J Biol Inorg Chem. 2015 Sep;20(6):957-69