Hughes, Christopher C. W. - University of California, Irvine - Department of Molecular Biology and Biochemistry

个人简介

Education and professional training: 1981 B.Sc. Department of Biochemistry, University College, University of London 1988 Ph.D. Department of Neuropathology, Institute of Psychiatry, King’s College, University of London 1988-1990 Research Fellow in Pathology, Brigham and Women’s Hospital, Boston, MA 1990-1991 Instructor, Department of Pathology, Brigham and Women’s Hospital, Boston, MA 1991-1995 Associate Research Scientist, Yale University School of Medicine, New Haven, CT Professional Experience: 1996-2001 Assistant Professor, University of California, Irvine 2001-2006 Associate Professor (with tenure), University of California, Irvine 2003-2006 Associate Professor, joint appointment in Biomedical Engineering 2006- Professor, University of California, Irvine 2006- Professor, joint appointment in Biomedical Engineering 2006-2011 Co-Director Growth Factors and Signaling Program, Chao Family Comprehensive Cancer Center 2011- Co-Director Oncoimaging and Biotechnology Program, Chao Family Comprehensive Cancer Center 2009- Chair, Dept. Molecular Biology & Biochemistry, UC Irvine 2009- Member of Leadership Council, Edwards Lifesciences Center for Advanced Cardiovascular Technology, UC Irvine 2013- Chair, HHT Foundation, Global Medical Research Advisory Board 2014- Interim Director, Edwards Lifesciences Center for Advanced Cardiovascular Technology

研究领域

Blood vessel development, angiogenesis in cancer, bioengineering of blood vessels and tissues

近期论文

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Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, and Hughes CCW. 2013. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterio. Thromb. Vasc. Biol. (in revision) Welch-Reardon KM, Ehsan SM, Wang K, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CCW. 2013 Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2). Arterio. Thromb. Vasc. Biol. (in revision) Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CCW, and George SC. 2013. A three-dimensional in vitro model of tumor angiogenesis and intravasation. Integrative Biology (in revision) Heylman C, Sobrino A, Shirure VS, Hughes CCW, and George SC 2013. A strategy for integrating essential 3D microphysiological systems of human organs for realistic anti-cancer drug screening. Exp. Biol. Med. (in revision) Hsu YH, Moya ML, Hughes CCW, George SC and Lee AP. 2013 microfluidic platform for generating large-scale nearly identical human microphysiological system arrays. Lab on a Chip 13: 2990-2998 Moya ML, Hsu, YH, Lee AP, Hughes CCW, and George SC. 2013. In vitro perfused human capillaries. Tissue Engineering 19: 730-737 Gong J, Archer R, Brown M, Fisher S, Chang C, Peacock MR, Hughes CCW, Freimark B. 2013 Measuring response to therapy by near-infrared imaging of tumors using a phosphatidylserine-targeting antibody fragment. Mol. Imaging 12: 244-56