Suetterlin, Christine - University of California, Irvine - Department of Developmental and Cell Biology

研究领域

The Regulation of Golgi and Centrosome Dynamics in Mammalian Cells – We are interested in how organelles of the pericentriolar region communicate with each other. In mammalian cells, Golgi membranes are positioned in close proximity to the centrosome, the major microtubule organizing center of a cell. This specific localization is only seen during interphase as Golgi membranes are fragmented and dispersed throughout the cytosol during mitosis. Another organelle that is positioned in this region of an infected cell is the inclusion, a membrane-bound compartment in which the bacterium, Chlamydia, resides and replicates. As an obligatory intracellular parasite, Chlamydia has extensive, but often poorly characterized interactions with its host.

近期论文

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Chen A., Johnson KA., Lee, JK., *Sütterlin, C.., and *Tan M.: “CPAF: a chlamydial protease without a substrate”. PloS Pathogens 8, e1002842 – * joint corresponding authors Karanikolas and Sütterlin, C: Functional associations between the Golgi apparatus and the centrosome in mammalian cells. In: The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease, published by Humana Press ISBN 978-1-62703-034-2 Schnermann MJ, Beaudry CM, Genung NE, Canham SM, Untiedt NL, Karanikolas BD, Sütterlin C, Overman LE. (2011): Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes. J Am Chem Soc. 2;133:17494-503. PMID: 21988207 A. Kodani, Tonthat, V., Wu, B. and Sütterlin, C. (2010) Par6 interacts with the dynactin subunit p150Glued and is a critical regulator of centrosomal protein recruitment. Mol. Biol. Cell, in press. Schnermann, M.J., Beaudry, C.M., Egorova, A.V., Polishchuk, R.S., Sütterlin C*, Overman LE* (2010) Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core. PNAS 107:6158-63, PMCID: PMC2851978, * joint corresponding authors Sütterlin, C. and Colanzi, A. (2010) The Golgi – centrosome partnership during the cell cycle. J. Cell Biol. 188:621-8, PMCID: PMC2835931 A. Kodani and Sütterlin, C. (2009) A new function for an old organelle: Microtubule nucleation at the Golgi apparatus EMBO J., 28:995-6, PMCID: PMC2683713 K. Johnson, Tan, M., and Sütterlin, C. (2009) Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway Cellular Microbiology, 11, 1064–1073 Kodani, A., Kristensen, I., Huang, L., and Sütterlin, C. (2009): GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome function. Mol. Biol. Cell 20:1192-200 A. Kodani, Sütterlin, C. (2009): A new function for an old organelle: Microtubule nucleation at the Golgi apparatus. EMBO J., 28:995-6 K. Johnson, Tan M., and Sütterlin, C. (2009): Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway. Cellular Microbiology, 11:1064-73