Rafelski, Susanne - University of California, Irvine - Department of Developmental and Cell Biology

研究领域

Control of mitochondrial network size, topology and function in budding yeast cells. The long-term goal of my lab is to understand the spatial and dynamic organization of the cell at all levels of complexity: -How is the 3-dimensional geometry (size, shape, position, dynamics) of organelles and intracellular structures generated at the molecular level, regulated system-wide to respond to the needs of the cell, and integrated to organize the cell? -How does improper internal organization contribute to the cellular basis of disease?

近期论文

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Pesce, GC, Rafelski, SM, Bernales, S, Viana, MP, da F. Costa, L, Marshall, WF, Walter, P. A mitotic cell cycle checkpoint controls mitochondrial expansion during cell division. In Revision. Viana MP, Lim S, Rafelski SM. Methods Cell Biol. 2015;125:77-93. doi: 10.1016/bs.mcb.2014.10.003. Epub 2015 Jan 8. Jayashankar V, Rafelski SM. Curr Opin Cell Biol. 2014 Feb;26:34-40. doi: 10.1016/j.ceb.2013.09.002. Epub 2013 Oct 8. Review. Rafelski, SM (2013). Mitochondrial network morphology: building an integrative, geometrical view. BMC Biology 11:71. Rafelski, SM, Viana, MP, Zhang, Y, Chan, YHM, Thorn, KS, Yam, P, Fung, JC, Li, H, da F. Costa, L, Marshall, WF. (2012) Mitochondrial network size scaling in budding yeast. Science 338(6108): 822-4. Wasilewski, M, Semenzato, M, Rafelski, SM, Robbins, JR, Bakardjiev, AI, Scorrano, L. (2012) Optic Atrophy1- dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Current Biology, 22(13): 1228-34. Melton-Witt, JA*, Rafelski, SM*, Portnoy, DA, Bakardjiev, AI. (2012) Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs. Infection & Immunity 80(2): 720-32. [*co-first authors] Rafelski, SM*, Keller, LC*, Alberts, JB, Marshall, WF. (2011) Apparent diffusive motion of centrin foci in living cells: implications for diffusion-based motion in centriole duplication. Physical Biology 8(2): 026010. [*co-first authors] Rafelski, SM*, Alberts, JB*, Odell GM. (2009) An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility. PLOS Computational Biology 5(7): e1000434. [*co-first authors] Rafelski, SM and Marshall, WF. (2008) Building the cell: engineering design principles of cellular architecture. Nature Reviews Molecular Cell Biology 9(8): 593-602.