Donovan, Peter J. - University of California, Irvine - Department of Biological Chemistry

个人简介

Peter Donovan, received his Ph.D in Cell Biology from University College, London and carried out postdoctoral studies at St. George’s Medical School in London where he began his studies on germ cell development. He established his own independent laboratory at the National Cancer Institute where his laboratory pioneered the development of pluripotent stem cells from germ cells in mice and, with John Gearhart, developed the same cell type from human germ cells. He then moved to the Kimmel Cancer Center in Philadelphia before being recruited to become co-director of the Stem Cell Program in the Institute for Cell Engineering at Johns Hopkins University. He moved to UC Irvine in 2006 and was Co-Director of the Sue and Bill Gross Stem Cell Research Center until 2010 and then Director until 2013. Dr. Donovan is the Program Director for the UC Irvine Training Grant in Stem Cell Biology and the Principle Investigator for the UC Irvine Shared Research Laboratory and Stem Cell Techniques Course, both funded by the California Institute for Regenerative Medicine. He serves as a member of the Scientific Advisory Board of the Max Plank Institute for Biomolecular Medicine in Munster, Germany and is a member of the Steering Committee of the Hinxton Group, an international group that examines the ethical, moral and legal issues associated with stem cell research.

研究领域

Research in my lab is focused on understanding the molecular mechanisms by which pluripotent stem cells can be formed from primordial germ cells (PGCs) and the mechanisms by which pluripotent stem cells are themselves maintained in the pluripotent state. Specifically we are interested in how fibroblast growth factor signaling changes PGCs into a pluripotent stem cell termed an embryonic germ (EG) cell. In addition we are interested in understanding how multiple signaling pathways help maintain pluripotent stem cells in the stem cell state. We utilize all the techniques of modern mammalian molecular genetics to dissect these various pathways. Finally, we are utilizing our ability to genetically manipulate pluripotent stem cells to both develop models of human disease and to alter patient-derived stem cells to develop better treatments for human disease.

近期论文

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Easley, C.A., Ben-Yehudah, A., Redinger, C.J., Oliver, S.L., Varum, S.T., Eisinger, V.M., Carlisle, D.L., Donovan, P.J. and Schatten, G.P. (2010) mTOR-mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells. Cellular Reprogramming, 12(3):263 Denham, M., Leung, J., Tay, C., Wong, R.C.B., Donovan, P.J., Dottoir, M. and Pebay, A. (2009). A new feeder-free technique to expand human embryonic stem cells and induced pluripotent stem cells. The Open Stem cell Journal. 1, 76-82. Acharya, M.M., Christie, L.A., Lan, M, Donovan, P.J., Cotman, C.W., Fike, J.R..and Limoli, C.L. (2009). Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc. Natl. Acad. Sci. (USA). 106(45):19150-5 Shuda, K.M., Schindler, K., Ma, J., Schultz, R.M. and Donovan, P.J. (2009). Aurora Kinase B regulates modulates chromosome alignment in mouse oocytes. Mol. Reprod. 76 (11):1094-105. Zeng, W., de Greef, J.C., Chen, Y-Y., Chien, R., Kong, X., Gregson, H.C., Winokur, S.T., Pyle, A., Robertson, K.D., Schmiesing, J.A., Kimonis, V. E., Balog, J., Frants, R.R., Ball, A.R., Lock, L.F., Donovan, P.J., van der Maarel, S. M. and Yokomori, K. (2009). Specific loss of histone H3 lysine 9 trimethylation and HP1γ/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLOS Genetics. 5(7):e1000559.