个人简介

1970 Ph.D., Adelaide University, South Australia 1966 B.Sc., Adelaide University, South Australia

研究领域

Analytical and Protein Chemistry

Prof. Hancock is the founding Editor-in-Chief of the ACS publication, Journal of Proteomic Research, which is a leading journal publishing research in related areas of functional genomics, proteomic methodological research, disease and agricultural proteomics as well as metabanomics. Prof. Hancock’s research is focused on applying new analytical technology to current problems in the biotechnology industry as well as cancer proteomics and the plasma proteome. Also Prof. Hancock is a co-leader of an international, collaborative initiative called the chromosome-centric human proteome project (C-HPP) which has enlisted 24 national teams, each focusing their efforts on the proteins contained on a single chromosome — each of which contains hundreds to thousands of genes. Also Dr. Hancock’s team, which includes Stanford, Michigan and Manitoba University, will characterize the proteins on chromosome number 17, including the important breast cancer gene, ERBB2. Ultimately, the goal is to have a full protein database within ten years, which will help clinicians analyze a patient’s true biological state and design targeted therapies for their conditions. In 2012, the Journal of Proteome Research published a special issue which contained 35 papers describing progress by the chromosome teams and in 2013 there have been dedicated chromosome meetings in Berlin and Yokohama with further progress on the initial phase of the project. In conclusion, the initiative has been launched, and the momentum has been very strong with substantial global resources committed to the project.

近期论文

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Application of Reversed Phase High Performance Liquid Chromatography in Solid Phase Peptide Synthesis: High Pressure Liquid Chromatography of Amino Acids Peptides and Proteins XIII. Part XII Ref. 2 MTH Hearn, CA Bishop, WS Hancock, DRK Harding, GD Reynolds Journal of Liquid Chromatography 2 (1), 1-21 Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly‐available database GS Omenn, M Adamski, TW Blackwell, R Menon, H Hermjakob, ... Exploring the Human Plasma Proteome, 1-35 A novel method of activation of cross-linked agaroses with 1, 1'-carbonyldiimidazole which gives a matrix for affinity chromatography devoid of additional charged groups. GS Bethell, JS Ayers, WS Hancock, MT Hearn Journal of Biological Chemistry 254 (8), 2572-2574 A new micro-test for the detection of incomplete coupling reactions in solid-phase peptide synthesis using 2, 4, 6-trinitrobenzene-sulphonic acid WS Hancock, JE Battersby Analytical biochemistry 71 (1), 260-264 Analysis of oligonucleotides by HPLC-electrospray ionization mass spectrometry A Apffel, JA Chakel, S Fischer, K Lichtenwalter, WS Hancock Analytical chemistry 69 (7), 1320-1325 Approach to the comprehensive analysis of glycoproteins isolated from human serum using a multi-lectin affinity column Z Yang, WS Hancock Journal of chromatography A 1053 (1), 79-88 Integrated nucleic acid analysis system for MALDI-TOF MS WS Hancock, JA Chakel, JA Apffel, K Lichtenwalter US Patent 5,716,825 A HUPO test sample study reveals common problems in mass spectrometry–based proteomics AW Bell, EW Deutsch, CE Au, RE Kearney, R Beavis, S Sechi, T Nilsson, ... Nature methods 6 (6), 423-430 Reversed-phase, high-pressure liquid chromatography of peptides and proteins with ion-pairing reagents WS Hancock, CA Bishop, RL Prestidge, DR Harding, MT Hearn Science 200 (4346), 1168-1170 Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling L Zang, DP Toy, WS Hancock, DC Sgroi, BL Karger Journal of proteome research 3 (3), 604-612 Activated matrix and method of activation JS Ayers, GS Bethell, WS Hancock, MTW Hearn US Patent 4,330,440 The human proteome project: current state and future direction P Legrain, R Aebersold, A Archakov, A Bairoch, K Bala, L Beretta, ... Molecular & cellular proteomics 10 (7), M111. 009993 Targeted proteomics of low-level proteins in human plasma by LC/MSn: using human growth hormone as a model system SL Wu, H Amato, R Biringer, G Choudhary, P Shieh, WS Hancock Journal of proteome research 1 (5), 459-465 Integrated planar liquid handling system for maldi-TOF MS JA Apffel, JA Chakel, WS Hancock, K Lichtenwalter US Patent 5,705,813 Formation of isoaspartate at two distinct sites during in vitro aging of human growth hormone. BA Johnson, JM Shirokawa, WS Hancock, MW Spellman, LJ Basa, ... Journal of Biological Chemistry 264 (24), 14262-14271 Recommendations for biomarker identification and qualification in clinical proteomics H Mischak, G Allmaier, R Apweiler, T Attwood, M Baumann, A Benigni, ... Science translational medicine 2 (46), 46ps42-46ps42 Human Proteinpedia enables sharing of human protein data S Mathivanan, M Ahmed, NG Ahn, H Alexandre, R Amanchy, PC Andrews, ... Nature biotechnology 26 (2), 164-167 The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome YK Paik, SK Jeong, GS Omenn, M Uhlen, S Hanash, SY Cho, HJ Lee, ... Nature biotechnology 30 (3), 221-223 Temperature as a variable in reversed-phase high-performance liquid chromatographic separations of peptide and protein samples: I. Optimizing the separation of a growth hormone tryptic digest WS Hancock, RC Chloupek, JJ Kirkland, LR Snyder Journal of Chromatography A 686 (1), 31-43 A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC‐MS/MS Z Yang, WS Hancock, TR Chew, L Bonilla Proteomics 5 (13), 3353-3366