Ortiz, Rudy M. - University of California, Merced

研究领域

Research in my lab focuses on renal and metabolic adaptations to perturbations such as hypertension and prolonged fasting, in either a natural or induced state. Questions regarding electrolyte and water regulation and natural prolonged food deprivation in a variety of animal models including seals and dolphins help us better understand the adaptations these animals have evolved to deal with these seemingly extreme conditions. Comparative species are viable models to address several of the pathophysiological conditions commonly seen in humans. In addition, our lab is interested in the contributions of aldosterone and angiotensin II to the manifestation of hypertension, and renal and cardiovascular disease. We are also pursuing studies that address the link between diabetes and obesity with hypertension. The role of oxidative stress and inflammation in hypertension and diabetes is of research interest as well as the adaptive mechanisms evolved by seals to counter oxidative stress during prolonged fasting and diving- and sleep apnea-induced hypoxia.

近期论文

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Vázquez-Medina, JP, DE Crocker, HJ Forman, RM Ortiz. 2010. Prolonged fasting does not increase oxidative damage or inflammation in a naturally adapted mammal, the northern elephant seal. J Experimental Biology, In Press Ortiz, RM, H Kobori, D Conte, and LG Navar. 2010. Chronic angiotensin II infusion stimulates corticosterone in association with body mass reduction. Growth Hormone & IGF Research, In Press Rodriguez, R, J Mowrer, J Romo, A Aleman, S Weffer and RM Ortiz. 2010. Ethnic and gender disparities in adolescent obesity in a rural US population. Clinical Pediatrics, In Press Ortiz, RM, B Long, D Casper, CL Ortiz and TM Williams. 2010. Biochemical and hormonal changes during acute food deprivation and re-feeding in bottlenose dolphins (Tursiops truncatus). Marine Mammal Science 26: 409-419 Ortiz, RM, A Mamalis and LG Navar. 2009. Aldosterone receptor antagonism reduces urinary C-reactive protein excretion in angiotensin II-infused, hypertensive rats. Journal of the American Society of Hypertension 3: 184-191 Ortiz, RM. 2008. Delineating the contributions of AT1a and AT1b receptor mediated uptake of Ang II in kidneys and adrenals. American Journal of Physiology Renal Physiol 294: F291-F292 Graciano ML, A Nishiyama, K Jackson, DM Seth, RM Ortiz, MC Prieto-Carrasquero, H Kobori, and LG Navar. 2008. Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. American Journal of Physiology Renal Physiol 294: F161-F169 Ortiz, RM, ML Graciano, JJ Mullins, and KD Mitchell. 2007. Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension in Cyp1a1-Ren2 transgenic rats. American Journal of Physiology Renal Physiol 293: F1584-F1591 Ortiz, RM, ML Graciano, D Seth, M Awayda and LG Navar. 2007. Aldosterone receptor antagonism exacerbates intrarenal angiotensin II augmentation in Ang II-dependent hypertension. American Journal of Physiology Renal Physiol 293: F139-F147 Ortiz, RM, DE Crocker, DS Houser, and PM Webb. 2006. Angiotensin II and aldosterone increase with fasting in breeding adult male northern elephant seals (Mirounga angustirostris). Physiological and Biochemical Zoology 79 (6): 1106-1112