Barlow, Miriam - University of California, Merced

研究领域

Our research focuses on the evolution of antimicrobial resistance. Antimicrobial resistance is a serious problem affecting thousands of lives each year. Recent outbreaks of Methicillin Resistant Staphylococcus aureus (MRSA) have illustrated the severity of the resistance problem. Reports in the popular press (New York Times, Oct 16, 2007) have identified MRSA as a greater health threat than HIV. However, the health threats posed by MRSA are only a small fraction of the antimicrobial resistance problem. The causative agents of deadly diseases such as tuberculosis and pneumonia are also becoming resistant to nearly all existing antibiotics as well. Our lab is investigating several approaches to combat the threat of resistance. These include: 1. Developing diagnostic tools to rapidly identify infectious bacteria 2. Studying the population genetics of antimicrobial resistance genes to determine what causes them to spread 3. Developing methods to infer what causes antimicrobial resistance to evolve 4. Experimentally predicting how important resistance genes will evolve in the future These approaches implement evolutionary biology, microbiology, and biochemistry. In addition to promoting strategies to reduce antimicrobal resistance, our research is also increasing our understanding of the processes that drive the evolution of antimicrobial resistance. We are developing antimicrobial resistance as a model system for studying basic microbial processes.

近期论文

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Barlow M and Hall BG. 2002. Predicting Evolutionary Potential: In Vitro Evolution Accurately Reproduces Natural Evolution of the TEM beta-Lactamase. Genetics 160: 823-832. Barlow M and Hall BG. 2002. Origin and Evolution of the ampC b-lactamases of Citrobacter freundii. Antimicrobial Agents Chemotherapy 46: 1190-1198. Barlow M and Hall BG. 2002. Phylogenetic Analysis Shows that the OXA b-lactamase Genes have been on Plasmids for Millions of Years. Journal of Molecular Evolution 55:314-321. Barlow M and Hall BG. 2003. Experimental Prediction of the Natural Evolution of Antibiotic Resistance. Genetics 163:1237-12341. Barlow M and Hall BG. 2003. Experimental Prediction of the Evolution of Cefepime Resistance from the CMY-2 AmpC beta-lactamase. Genetics 164:23-29. Hall BG, Salipante S. and Barlow M. 2003 The Metallo-beta-Lactamases Fall into Two Distinct Phylogenetic Groups. Journal of Molecular Evolution 57:249-254 Hall BG and Barlow M. 2003 Structure Based Phylogenies of the Serine b-Lactamases. Journal of Molecular Evolution 57:255-260. Salipante SJ, Barlow M, and Hall BG. 2003 GeneHunter, a Transposon Tool for Identification and Isolation of Cryptic Antibiotic Resistance Genes. Antimicrobial Agents Chemotherapy 47:3840-3845. Hall BG, Salipante SJ and Barlow M. 2004 Independent Origins of Subgroup Bl+B2 and Subgroup B3 Metallo-beta-Lactamases. Journal of Molecular Evolution. 59:133–141. Hall BG, and Barlow M. 2004. Evolution of the Serine beta-Lactamases: Past, Present and Future. Drug Resistance 7:111-23.