Booth, Raymond - Northeastern University

个人简介

BS (Pharmacy), Northeastern University PhD (Pharmaceutical Sciences) University of California at San Francisco

研究领域

Drug discovery and development for neuropsychiatric and neurodegenerative disorders

近期论文

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Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors. Sakhuja R, Kondabolu K, Córdova-Sintjago T, Travers S, Vincek AS, Kim MS, Abboud KA, Fang L, Sun Z, Canal CE, Booth RG. Bioorg Med Chem. 2015 Apr 1;23(7):1588-600. doi: 10.1016/j.bmc.2015.01.060. Epub 2015 Feb 7. PMID: 25703249 Related citations Select item 25467718 Happiness, stress, a bit of vulgarity, and lots of discursive conversation: a pilot study examining nursing students' tweets about nursing education posted to Twitter. Booth RG. Nurse Educ Today. 2015 Feb;35(2):322-7. doi: 10.1016/j.nedt.2014.10.012. Epub 2014 Oct 28. PMID: 25467718 Related citations Select item 25382408 Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens. Kasper JM, Booth RG, Peris J. Synapse. 2015 Feb;69(2):78-85. doi: 10.1002/syn.21790. Epub 2014 Nov 20. PMID: 25382408 Related citations Select item 24729635 Aromatic interactions impact ligand binding and function at serotonin 5-HT2C G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies. Córdova-Sintjago T, Villa N, Fang L, Booth RG. Mol Phys. 2014 Jan 1;112(3-4):398-407. PMID: 24729635 Free PMC Article Related citations Select item 24563531 A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses. Canal CE, Morgan D, Felsing D, Kondabolu K, Rowland NE, Robertson KL, Sakhuja R, Booth RG. J Pharmacol Exp Ther. 2014 May;349(2):310-8. doi: 10.1124/jpet.113.212373. Epub 2014 Feb 21. Erratum in: J Pharmacol Exp Ther. 2014 Jun 1;349(3):533. PMID: 24563531 Related citations Select item 24080681 Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands. Canal CE, Cordova-Sintjago T, Liu Y, Kim MS, Morgan D, Booth RG. J Pharmacol Exp Ther. 2013 Dec;347(3):705-16. doi: 10.1124/jpet.113.208637. Epub 2013 Sep 30. PMID: 24080681 Free PMC Article Related citations Select item 23913978 Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies. Córdova-Sintjago T, Sakhuja R, Kondabolu K, Canal CE, Booth RG. Int J Quantum Chem. 2012 Dec 15;112(24):3807-3814. PMID: 23913978 Free PMC Article Related citations Select item 23665356 Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications. Morgan D, Kondabolu K, Kuipers A, Sakhuja R, Robertson KL, Rowland NE, Booth RG. Neuropharmacology. 2013 Sep;72:274-81. doi: 10.1016/j.neuropharm.2013.04.051. Epub 2013 May 9. PMID: 23665356 Free PMC Article Related citations Select item 23353901 Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Canal CE, Booth RG, Morgan D. Neuropharmacology. 2013 Jul;70:112-21. doi: 10.1016/j.neuropharm.2013.01.007. Epub 2013 Jan 23. PMID: 23353901 Free PMC Article Related citations Select item 23036060 Health tweets: an exploration of health promotion on twitter. Donelle L, Booth RG. Online J Issues Nurs. 2012 Sep 30;17(3):4. PMID: 23036060 Free Article Related citations Select item 23036058 Social media use in nursing education. Schmitt TL, Sims-Giddens SS, Booth RG. Online J Issues Nurs. 2012 Sep 30;17(3):2. PMID: 23036058 Free Article Related citations Select item 25013351 Molecular determinants of ligand binding at the human histamine H1 receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H1 homology and crystal structure models. Cordova-Sintjago TC, Fang L, Bruysters M, Leurs R, Booth RG. J Chem Pharm Res. 2012 Jun;4(6):2937-2951. PMID: 25013351 Free PMC Article Related citations Select item 22411411 Examining the functionality of the DeLone and McLean information system success model as a framework for synthesis in nursing information and communication technology research. Booth RG. Comput Inform Nurs. 2012 Jun;30(6):330-45. doi: 10.1097/NXN.0b013e31824af7f4. Review. PMID: 22411411 Related citations Select item 22020288 Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation. Canal CE, Cordova-Sintjago TC, Villa NY, Fang LJ, Booth RG. Eur J Pharmacol. 2011 Dec 30;673(1-3):1-12. doi: 10.1016/j.ejphar.2011.10.006. Epub 2011 Oct 12. PMID: 22020288 Free PMC Article Related citations Select item 21982496 A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action. Ghoneim OM, Ibrahim DA, El-Deeb IM, Lee SH, Booth RG. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6714-23. doi: 10.1016/j.bmcl.2011.09.046. Epub 2011 Sep 21. PMID: 21982496 Free PMC Article Related citations Select item 20975537 Student perceptions of online participation in baccalaureate nursing computer-conferencing courses. Booth RG, Andrusyszyn MA, Iwasiw C. Comput Inform Nurs. 2011 Mar;29(3):191-8. doi: 10.1097/NCN.0b013e3181f9dd37. PMID: 20975537 Related citations Select item 20161011 New Approach to 4-Phenyl-β-aminotetralin from 4-(3-Halophenyl)tetralen-2-ol Phenylacetate. Vincek AS, Booth RG. Tetrahedron Lett. 2009 Sep 9;50(36):5107-5109. PMID: 20161011 Free PMC Article Related citations Select item 19397907 (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. Booth RG, Fang L, Huang Y, Wilczynski A, Sivendran S. Eur J Pharmacol. 2009 Aug 1;615(1-3):1-9. doi: 10.1016/j.ejphar.2009.04.035. Epub 2009 May 3. PMID: 19397907 Free PMC Article Related citations Select item 18692085 Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice. Rowland NE, Crump EM, Nguyen N, Robertson K, Sun Z, Booth RG. Pharmacol Biochem Behav. 2008 Nov;91(1):176-80. doi: 10.1016/j.pbb.2008.07.004. Epub 2008 Jul 19. PMID: 18692085 Free PMC Article Related citations Select item 18345497 Molecular determinants of ligand-directed signaling for the histamine H1 receptor. Booth RG, Fang L, Wilczynski A, Sivendren S, Sun Z, Travers S, Bruysters M, Sansuk K, Leurs R. Inflamm Res. 2008;57 Suppl 1:S43-4. doi: 10.1007/s00011-007-0621-3. No abstract available. PMID: 18345497 Free PMC Article Related citations