Zipursky, S. Lawrence - University of California, Los Angeles

研究领域

Larry Zipursky is interested in uncovering the cellular rules and underlying molecular mechanisms by which neurons make highly specific patterns of synaptic connections during development. Communication between neurons relies on precise patterns of interconnections between them. We are interested in understanding the molecular mechanisms by which these connections, referred to as synapses, are specified. Presumably specific molecular labels on the surface of different neurons provide a basis for the cellular recognition that underlies this specificity. Identifying these labels and understanding how they work is the central goal of my laboratory.

近期论文

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Tadros W, Xu S, Akin O, Yi CH, Shin GJ, Millard SS, Zipursky SL. Dscam Proteins Direct Dendritic Targeting through Adhesion. Neuron. 2016 Feb 3;89(3):480-93. Zhang KX, Tan L, Pellegrini M, Zipursky SL, McEwen JM. Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals. Cell Rep. 2016 Feb 9;14(5):1258-71. Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL. Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila. Cell. 2015 Dec 17;163(7):1756-69. Pecot MY, Chen Y, Akin O, Chen Z, Tsui CY, Zipursky SL. Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system. Neuron. 2014 Apr 16;82(2):320-33. Chen Y, Akin O, Nern A, Tsui CY, Pecot MY, Zipursky SL. Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. Neuron. 2014 Jan 22;81(2):280-93. Miura SK, Martins A, Zhang KX, Graveley BR, Zipursky SL. Probabilistic splicing of Dscam1 establishes identity at the level of single neurons. Cell. 2013 Nov 21;155(5):1166-77. Zipursky SL, Grueber WB. The molecular basis of self-avoidance. Annu Rev Neurosci. 2013 Jul 8;36:547-68. Pecot MY, Tadros W, Nern A, Bader M, Chen Y, Zipursky SL. Multiple interactions control synaptic layer specificity in the Drosophila visual system. Neuron. 2013 Jan 23;77(2):299-310. Wu W, Ahlsen G, Baker D, Shapiro L, Zipursky SL. Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo. Neuron. 2012 Apr 26;74(2):261-8