Hong, Weizhe - University of California, Los Angeles - Department of Biological Chemistry

个人简介

Dr. Weizhe Hong is an Assistant Professor in the Department of Biological Chemistry and the Department of Neurobiology at UCLA School of Medicine. Dr. Hong received a B.S. degree in biological sciences at Tsinghua University. When he was in high school and college, he worked with Zengyi Chang, on mechanisms of protein folding and microbial stress response, first at Tsinghua University and then at Peking University. He received his PhD degree in 2012 at Stanford University, under the guidance of Liqun Luo. His PhD research focused on the cellular and molecular mechanisms of wiring specificity during olfactory system development. He was a Helen Hay Whitney Fellow in David Anderson's Laboratory, working on neural mechanisms underlying social and emotional behaviors. Dr. Hong received the Genetics Society of America’s Larry Sandler Memorial Award for the best PhD dissertation on the Drosophila research, and presented the Larry Katz Memorial Lecture in the Cold Spring Harbor Conference for the best PhD dissertation on neural circuit research.

研究领域

The Hong Lab employs a multidisciplinary approach to identify the molecular and neural circuit mechanisms underlying normal social behaviors as well as their dysregulations in neuropsychiatric disorders. Social behaviors are essential for the survival and reproduction of animals. The control of social behavior is of particular importance in social species such as humans. Abnormalities in social behaviors are associated with several neuropsychiatric disorders, such as autism spectrum disorders and schizophrenia. Despite its importance, many fundamental questions regarding social behavior and its disorders still remain unanswered. We aim to understand how social behavior is regulated at the molecular and circuit level and how social behavior and social experience lead to molecular and circuit level changes in the brain.

近期论文

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Hong W, Kennedy A, Burgos-Artizzu X, Zelikowsky M, Navonne S, Perona P, Anderson DJ. (2015) Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning. Proc. Natl. Acad. Sci. USA. 112, E5351-5360. [ PDF ] Pearce MM, Spartz EJ, Hong W, Luo L, Kopito RR. (2015) Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain. Nature Communications. 13, 6:6768. [ PDF ] Ward A*, Hong W*, Favaloro V, Luo L. (2015) Toll Receptors Instruct Axon and Dendrite Targeting and Participate in Synaptic Partner Matching in a Drosophila Olfactory Circuit. Neuron. 85, 1013-1028. (*co-first authors) [ PDF ] Hong W, Kim DW, Anderson DJ. (2014) Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets. Cell. 158, 1348-1361. [ PDF | Previewed by Nature Review Neuroscience | Caltech News ] Hong W, Luo L. (2014) Genetic Control of Wiring Specificity in the Fly Olfactory System. Genetics. 196, 17-29. [ PDF ] Hong W. (2013) Assembly of A Neural Circuit. Science. 342, 1186. (doi: 10.1126/science.1247568) [ PDF ] Mosca TJ*, Hong W*, Dani VS, Favaloro V, Luo L. (2012) Trans-synaptic Teneurin signaling in neuromuscular synapse organization and target choice. Nature. 484, 237-241. (*co-first authors) [ PDF ] Hong W, Mosca TJ, Luo L. (2012) Teneurins instruct synaptic partner matching in an olfactory map. Nature. 484, 201-207. [ PDF ] Hong W*, Wu YE*, Fu X, Chang Z. (2012) Chaperone-dependent mechanisms for acid resistance in enteric bacteria. Trends in Microbiology. 20, 328-335. (*co-first authors) [ PDF ] de Wit J*, Hong W*, Luo L, Ghosh A. (2011) Role of leucine-rich repeat proteins in the development and function of neural circuits. Annual Review of Cell and Developmental Biology. 27, 697-729. (*co-first authors) [ PDF ]