Wang, Danny Jiong Jiong - University of California, Los Angeles

个人简介

Dr. Wang is Professor of Neurology and Director of Imaging Technology Innovation in the Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California. He received Ph.D. in Biophysics from the University of Science and Technology of China (USTC), and postdoc training in the Departments of Radiology and Neurology at the University of Pennsylvania Medical Center. He has been an Assistant Professor of Radiology and Neurology at UPenn, Associate and Full Professor of Neurology and Radiology at UCLA before joining USC in 2016. During the past 20 years, Dr. Wang’s research has been focused on the technical development and clinical translations of novel functional and physiological Magnetic Resonance Imaging (MRI) technologies, in particular noninvasive blood flow/perfusion imaging. He has been supporting the scientific community by disseminating arterial spin labeling (ASL) sequences to approximately 200 Siemens imaging research centers around the world. His recent research interests include developing novel neuroimaging methods to understand neuromodulation effects on the brain. In addition to MRI, Dr. Wang has research interests in the technical development and clinical applications of Computed Tomography (CT) and Positron Emission Tomography (PET).

研究领域

Cerebral blood flow (CBF) imaging using arterial spin labeling (ASL) ASL is a noninvasive technique to measure CBF by using magnetically labeled arterial blood water as an endogenous tracer. A main research direction at LOFT is development and translation of advanced ASL techniques. In particular, pseudo-continuous ASL (pCASL) with background suppressed (BS) 3D GRASE sequence showed great promise in perfusion imaging of acute stroke and brain tumor (Figs. 1-3, thumbnail link to Gallery). Pediatric perfusion imaging using ASL is a main area of applications and is funded by NIMH R01 and ARRA. In a pilot project funded by UCLA Alzheimer’s Disease Research Center (ADRC), we are comparing ASL with positron emission tomography (PET) in mild cognitive impairment and early Alzheimer’s disease patients. Ongoing developments at LOFT include vessel-encoded ASL in chronic stroke and moya moya disease. We are also comparing ASL with dynamic susceptibility contrast (DSC) perfusion MRI and digital subtraction angiography (DSA) in stroke patients.

近期论文

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Smith Robert X, Jann Kay, Ances Beau, Wang Danny J J Wavelet-based regularity analysis reveals recurrent spatiotemporal behavior in resting-state fMRI Human brain mapping, 2015; 36(9): 3603-20. Wang Ting, Li Yanhua, Guo Xinhong, Huang Diandian, Ma Lin, Wang Danny J J, Lou Xin Reduced perfusion in normal-appearing white matter in mild to moderate hypertension as revealed by 3D pseudocontinuous arterial spin labeling Journal of magnetic resonance imaging : JMRI, 2015; 36(9): . Palomares Jose A, Tummala Sudhakar, Wang Danny J J, Park Bumhee, Woo Mary A, Kang Daniel W, Lawrence Keith S St, Harper Ronald M, Kumar Rajesh Water Exchange across the Blood-Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion-Weighted Pseudo-Continuous Arterial Spin Labeling Study Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2015; 36(9): . Zou Qihong, Miao Xinyuan, Liu Dapeng, Wang Danny J J, Zhuo Yan, Gao Jia-Hong Reliability comparison of spontaneous brain activities between BOLD and CBF contrasts in eyes-open and eyes-closed resting states NeuroImage, 2015; 121(9): 91-105. Chen Jean, Jann Kay, Wang Danny J Characterizing Resting-State Brain Function using Arterial-Spin Labeling Brain connectivity, 2015; 121(9): . Mutsaerts Henri J M M, van Osch Matthias J P, Zelaya Fernando O, Wang Danny J J, NordhÃ¸y Wibeke, Wang Yi, Wastling Stephen, Fernandez-Seara Maria A, Petersen E T, Pizzini Francesca B, Fallatah Sameeha, Hendrikse Jeroen, Geier Oliver, GÃ¼nther Matthias, Golay Xavier, Nederveen Aart J, BjÃ¸rnerud Atle, Groote Inge R Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: implications for multi-center studies NeuroImage, 2015; 113(9): 143-52. Wright Susan N, Hong L Elliot, Winkler Anderson M, Chiappelli Joshua, Nugent Katie, Muellerklein Florian, Du Xioming, Rowland Laura M, Wang Danny J J, Kochunov Peter Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia Human brain mapping, 2015; 121(9): . Wang Yi, Moeller Steen, Li Xiufeng, Vu An T, Krasileva Kate, Ugurbil Kamil, Yacoub Essa, Wang Danny J J Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7 T NeuroImage, 2015; 113(9): 279-88.